Protein Alignment ppk24 and ASIC4

DIOPT Version :9

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_061144.4
• Gene: ASIC4 / 55515
• HGNCID: 21263
• Length: 539
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 130/627 - (20%)
• Similarity: 195/627 - (31%)
• Gaps: 192/627 - (30%)

  Fly     1 MPVEM------ESLDQKPFRLAVGRAAWWIPNPGRVARYPPIRTLAPNHLPGTSAEDTRKLSFAA 59
            ||:|:      ...|.||.....|.....:   |.||             ||.:..|....:..:
Human     1 MPIEIVCKIKFAEEDAKPKEKEAGDEQSLL---GAVA-------------PGAAPRDLATFASTS 49

  Fly    60 ALKDLLQNLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFLW-------GTYTKEQEALVT 117
            .|         |...:....|.....|..|   .:..||.|.|||:       |..|:..  ||.
Human    50 TL---------HGLGRACGPGPHGLRRTLW---ALALLTSLAAFLYQAAGLARGYLTRPH--LVA 100

  Fly   118 TMYHPMYPIWKVEFPAISVCSLNRISQRAAWQ----YAHNLSGKDPKQRNASHFYDQLKAFMYMY 178
              ..|..|.....|||:::|::||....|...    :..||:|..||.|      |..:|....|
Human   101 --MDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDR------DGHRAAGLRY 157

  Fly   179 YDPSDLMDIDNALRFQSFLDRFDTAKEELFFNTRNRMSALTPNCSDMFVSCRIAGRLFDC-MDKF 242
            .:| |::||.|....|                           .:||..||..:|.  .| ...|
Human   158 PEP-DMVDILNRTGHQ---------------------------LADMLKSCNFSGH--HCSASNF 192

  Fly   243 ETTLTSHGFCCTFNYDGRYVNKRDFRQRYFGPDMGLVLTLKTDPSDNFYKINGHNGYPDPFSGGV 307
            ....|.:|.|.|||.|.|    .....|..|  ||..|.:..|.....|...........|..|:
Human   193 SVVYTRYGKCYTFNADPR----SSLPSRAGG--MGSGLEIMLDIQQEEYLPIWRETNETSFEAGI 251

  Fly   308 AERV---------------AETGFNTLLPVRAKIFETLPE----ARSMSPSVRKCLFENEMPWIF 353
            ..::               ...||.|.:..:.:....||:    .|:.|.     |.|.|:....
Human   252 RVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESE-----LREPELQGYS 311

  Fly   354 ARHYTFSKCISACRAQSVVSLCECVPFSLPHRYIDGSE----KRIYCTLQHLACLKRYEFKWLNV 414
            |  |:.|.|...|..::|:..|.|....:|     |:|    ..||     :.|
Human   312 A--YSVSACRLRCEKEAVLQRCHCRMVHMP-----GNETICPPNIY-----IEC----------- 353

  Fly   415 ITSRENVTGLEHELQDAL--------YCPLCLASCTETRYSVRGAMTLGLPTPSQIKGPARSNPG 471
                     .:|.| |:|        :||   ..|..|||....:| :.:|.....:..||..
Human   354 ---------ADHTL-DSLGGGPEGPCFCP---TPCNLTRYGKEISM-VRIPNRGSARYLARKY-- 402

  Fly   472 PRANNSYGPASSSGSAKGPVHSSSAPAELAVVRIYFAETHIQYFRQIIKSAWYETFSTIGNICGI 536
             ..|.:|                 ......|:.::|.....:...|............:|...|:
Human   403 -NRNETY-----------------IRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGL 449

  Fly   537 IAGFSLIGICELLFFL-------AKQLWQACRAELRAELAHI 571
            ..|.|::.:.|:|.::       .|::|:..:..||.....|
Human   450 FIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGI 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:279230	111/528 (21%)
ASIC4	NP_061144.4	ASC	40..488	CDD:413546	117/567 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152109
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850