DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk24 and ASIC5

DIOPT Version :10

Sequence 1:NP_651860.2 Gene:ppk24 / 43702 FlyBaseID:FBgn0039839 Length:595 Species:Drosophila melanogaster
Sequence 2:NP_059115.1 Gene:ASIC5 / 51802 HGNCID:17537 Length:505 Species:Homo sapiens


Alignment Length:553 Identity:116/553 - (20%)
Similarity:190/553 - (34%) Gaps:172/553 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 DLLQNLSFHCYSKLVESGRRIQERFFWFVFHITALT---------VLIAFLWGTYTKEQEALVTT 118
            |...:.|||....:|::..:|: |..|.|..:.:::         :|..|.|.|         ||
Human    40 DFAISTSFHGIHNIVQNRSKIR-RVLWLVVVLGSVSLVTWQIYIRLLNYFTWPT---------TT 94

  Fly   119 MYHPMYPIWKVEFPAISVCSLNRISQRAA---------WQ------YAHNLSGKDPKQRNASHFY 168
            .....| :.|:||||::.|:|||....|.         |.      :...::......|.|:.|.
Human    95 SIEVQY-VEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFA 158

  Fly   169 DQLKAFMYMYYDPSDLMDIDNALRFQSFLDRFDTAKEELFFNTRNRMSALTPNCSDMFVSCRIAG 233
            ...:.|..:.:           :|.:.|           :.|            :...:.|...|
Human   159 ASHQNFSIVEF-----------IRNKGF-----------YLN------------NSTLLDCEFFG 189

  Fly   234 RLFDCMDK-FETTLTSHGFCCTFNYDGRYVNKRDFRQRYFGPDMGLVLTLKTDPSDNFYKINGHN 297
            :  .|..| |....|.:|.|.|||:......||....      .|..|:|..:.:...:..|...
Human   190 K--PCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSV------SGRGLSLLFNVNQEAFTDNPAL 246

  Fly   298 GYPDPFSGGV------AERVAE-TGFNTLLPVRAKIFETLPEARSMSPSVRKCLFENEMPW---- 351
            |:.|   .|:      .::|.: .|...|.||......|:.:.:::         ..|.||    
Human   247 GFVD---AGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTV---------HQEYPWGECN 299

  Fly   352 ------IFARHYTFSKCISACRAQSVVSLCECVPFSLPHRYIDGSEKRIYCTLQ-HLAC----LK 405
                  .|: .|:.|.|:..|:||.:...|.||||.||...|:       |.|| :.:|    |.
Human   300 PNIKLQNFS-SYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIE-------CDLQKYFSCVSPVLD 356

  Fly   406 RYEFKWLNVITSRENVTGLEHELQDALYCPLCLASCTETRYSVRGAMTLGLPTPSQIKGPARSNP 470
            ..|||.|..:.:..:            .||:   ||.|..|            |:.|        
Human   357 HIEFKDLCTVGTHNS------------SCPV---SCEEIEY------------PATI-------- 386

  Fly   471 GPRANNSYGPASSSGSAKGPVHSSS--------APAELAVVRIYFAETHIQYFRQIIKSAWYETF 527
                  ||   ||..|.|...:.|.        ....|..:.|.:::.:.:..:|....:..|..
Human   387 ------SY---SSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELL 442

  Fly   528 STIGNICGIIAGFSLIGICELLFFLAKQLWQAC 560
            :.:|...|:..|.|||.|.|::.:|....:..|
Human   443 ADLGGQLGLFCGASLITIIEIIEYLFTNFYWIC 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk24NP_651860.2 ASC 65..551 CDD:459966 113/540 (21%)
ASIC5NP_059115.1 Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5 1..30
ASC 41..466 CDD:459966 113/541 (21%)
GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348 454..456 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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