Protein Alignment ppk24 and asic1b

DIOPT Version :10

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_999956.1
• Gene: asic1b / 407672
• ZFINID: ZDB-GENE-040513-1
• Length: 557
• Species: Danio rerio
• Alignment Length: 582
• Identity: 116/582 - (19%)
• Similarity: 199/582 - (34%)
• Gaps: 192/582 - (32%)

  Fly    41 PNHLPGTSAEDTRKLSFAAALKDLLQNLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFLW 105
            |:...|...|:...:|.|........:.:.|.:   ||..:....:..|.:..:.|:::.:.
Zfish    50 PDAYDGPEDEEAPDISLATFFGGCSLHGANHVF---VEDKKFSIRQGLWALVFLLAISMFLL--- 108

  Fly   106 GTYTKEQEALVTTMYHPMYP---------IWKVEFPAISVCSLNRISQRAAWQYAHNLSGKDPKQ 161
                   :.:...:|:..|.         ...:.||||::|:.|.. :|:...|
Zfish   109 -------QVVDRVIYYLQYDYVTLLDERNAKNMTFPAITLCNYNTF-RRSQLSY----------- 154

  Fly   162 RNASHFYDQLKAFMYMYYDPSDLMDIDNALRFQSFL--------------DRFDTAKEELFFN-T 211
                                |||:.:...|.::..:              .||..|:   ||| |
Zfish   155 --------------------SDLLFMGPLLGYEDNMAPGIPLAPEPDRQGSRFSLAE---FFNRT 196

  Fly   212 RNRMSALTPNCSDMFVSCRIAGRLFDC-MDKFETTLTSHGFCCTFN--YDGR--YVNKR------ 265
            |:||       .||.:.|..||:  :| .:.:....|.:|.|.|||  .|||  .:..:
Zfish   197 RHRM-------DDMLLECNFAGK--ECGAEHWREIFTRYGKCYTFNSGQDGRPLLITTKGGMGNG 252

  Fly   266 -----DFRQRYFGPDMGLVLTLKTDPS--DNFYKINGHNGYPDPFSGGVAERVAETGFNTLLPVR 323
                 |.:|..:.|..|     :||.:  :...|:..|.....||...:...|| .||.|.:..:
Zfish   253 LEIMLDIQQDEYLPVWG-----ETDETTFEAGIKVQIHTQDEPPFIDQLGFGVA-PGFQTFVSCQ 311

  Fly   324 AKIFETLPEARSMSPSVRKCLFENEMPW----------IFARHYTFSKCISACRAQSVVSLCEC- 377
            .:....||.                 ||          .|...|:.:.|...|..:.:|..|.|
Zfish   312 EQRLTYLPP-----------------PWGDCKATPIDSDFFNTYSITACRIDCETRYLVENCNCR 359

  Fly   378 ---VPFSLPHRYIDGSEKRIYCT-LQHLACLKRYEFKWLNVITSRENVTGLEHELQDALYCPLCL 438
               :|...|           ||| .|:..|..    ..|:.:..|:|.           || :|.
Zfish   360 MVHMPGDAP-----------YCTPEQYKECAD----PALDFLVERDND-----------YC-VCE 397

  Fly   439 ASCTETRYSVRGAMTLGLPTPSQIKGPARSNPGPRANNSYGPASSSGSAKGPVHSSSAPAELAVV 503
            ..|..|||. :....:.:|:.:..|..|:     :.|.:....|.:               :.|:
Zfish   398 TPCNMTRYG-KELSFVRIPSKASAKYLAK-----KYNKTEQYISDN---------------IMVL 441

  Fly   504 RIYFAETHIQYFRQIIKSAWYETFSTIGNI---CGIIAGFSLIGICELLFFLAKQL-WQACR 561
            .|:|...:.:...|  |.| ||....:|:|   .|:..|.|::.|.||..:|.:.: ::.||
Zfish   442 DIFFEALNYETIEQ--KKA-YELAGLLGDIGGQMGLFIGASILTILELFDYLYEVIKFKLCR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:459966	108/545 (20%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..57		2/6 (33%)
		ENaC	66..548	CDD:273304	112/566 (20%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	477..479		1/1 (100%)