DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk24 and asic1c

DIOPT Version :9

Sequence 1:	NP_651860.2	Gene:	ppk24 / 43702	FlyBaseID:	FBgn0039839	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_021325802.1	Gene:	asic1c / 407670	ZFINID:	ZDB-GENE-040513-3	Length:	562	Species:	Danio rerio

Alignment Length:	568	Identity:	115/568 - (20%)
Similarity:	196/568 - (34%)	Gaps:	169/568 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TSAEDTRKLSFAAALKDLLQNLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFLWGTYTKE 111
            |...:.:.::.|..|:..:..|. |.:|    ..:...:|.||.:..:..|.:|..:.|
Zfish    29 TLTHNIKDITTAFVLRTKVHGLK-HAFS----PHKSKTQRLFWLLALLVCLGLLFTWSW------ 82

  Fly   112 QEALVTTMYHP----MYPIW--KVEFPAISVCSLNRISQRAAWQYAHNLSGKDPKQRNASHFYDQ 170
             ..::..:.:|    :|.:|  .:.||||:.|:.||:                   |.:|...|.
Zfish    83 -NRILYLLSYPAVTKIYMVWSNNMTFPAITFCNQNRL-------------------RVSSLTRDD 127

  Fly   171 LKAFMYMYYDP--SDLMDIDNALRFQSF-LDRFDTAKEELF---------------FNTRNRMSA 217
            |      ||..  .|::.:::.|..||. :.:....:|.|.               .||...:..
Zfish   128 L------YYSGYWMDILHLNHTLNRQSVSMLKHSRHRERLLHLLDFSHYSPPPDQSLNTTEMIDR 186

  Fly   218 LTPNCSDMFVSCRIAGRLFDCMDK-FETTLTSHGFCCTFN--YDGRYVNKR-------------D 266
            |.....||.:.||..|.  :|..| |....|.:|.|.|||  .||..:...             |
Zfish   187 LGHQLQDMLLECRFRGE--NCTYKNFTPIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIMLD 249

  Fly   267 FRQRYFGPDMGLVLTLKTDPSDNFY----KINGHNGYPDPFSGGVAERVAETGFNTLLPVRAKIF 327
            .:|..:.|..|       |..:..|    |:..|:....||...:...|| .||.|.:..:.::.
Zfish   250 IQQDEYLPVWG-------DTDETSYEAGIKVQIHSQDEPPFIDQLGFGVA-PGFQTFVSCQQQLL 306

  Fly   328 ETLPEARSMSPSVRKCLFENEMPWIFARH----------YTFSKCISACRAQSVVSLCECVPFSL 382
            ..||.                 ||...|.          |:.:.|...|..:.::..|.|....:
Zfish   307 LYLPP-----------------PWGDCRSAPMDSEYFSTYSITACRIDCETRYLLENCNCRMVHM 354

  Fly   383 PHRYIDGSEKRIYCT-LQHLACLKRYEFKWLNVITSRENVTGLEHELQDALYCPLCLASCTETRY 446
            |     |:.  ..|| .|:..|..    ..|:.:..::|.           || :|...|..|||
Zfish   355 P-----GTS--TVCTPEQYKDCAD----PALDFLVEKDND-----------YC-VCDTPCNMTRY 396

  Fly   447 SVRGAMTLGLPTPSQIKGPARSNPGPRANNSYGPASSSGSAKGPVHSSSAPAELAVVRIYFAETH 511
            ....:| :.:|:.:..|..|:     :.|.:               .......:.|:.|:|...:
Zfish   397 GKELSM-VKIPSKASAKYLAK-----KFNKT---------------EQYITDNILVLDIFFEALN 440

  Fly   512 IQYFRQIIKSAWYETFSTIGNI---CGIIAGFSLIGICELLFFLAKQL 556
            .:...|  |.| ||....:|:|   .|:..|.|::.|.|:..:|.:.|
Zfish   441 YEKIEQ--KKA-YEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:279230	110/543 (20%)
asic1c	XP_021325802.1	ASC	34..531	CDD:322155	114/563 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586588
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950