DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk24 and asic4a

DIOPT Version :9

Sequence 1:	NP_651860.2	Gene:	ppk24 / 43702	FlyBaseID:	FBgn0039839	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_999952.1	Gene:	asic4a / 407668	ZFINID:	ZDB-GENE-040513-5	Length:	539	Species:	Danio rerio

Alignment Length:	556	Identity:	111/556 - (19%)
Similarity:	185/556 - (33%)	Gaps:	169/556 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PPIRTLAPNHLPGTSAEDTRKLSFAAALKDLLQNLSFHCYSKLVESGRRIQERFFWFVFHITALT 98
            ||.:.||               .||:|       .|.|..:.:..|||....:..|.:..:.:|.
Zfish    36 PPTKDLA---------------GFASA-------SSLHGINHIFVSGRLGVRQTLWALAFLVSLA 78

  Fly    99 VLIAFLWGTYTKEQEALVTTMYHPMYPIWKVE------FPAISVCSLNRISQRAAWQ----YAHN 153
            :   ||:    :..:..::.:.||.......|      |||:::|::||....|...    :..|
Zfish    79 L---FLY----QAAKCAISYLEHPHVTALNEEATPEMVFPAVTICNINRFRFSALTDADIYHLAN 136

  Fly   154 LSGKDPKQRNASHFYDQLKAFMYMYYDPSDLMDIDNALRFQSFLDRFDTAKEELFFNTRNRMSAL 218
            |:|..||.::.....|       :.|...|:.||.|....|
Zfish   137 LTGLPPKNKDGHKPTD-------LEYPAPDMQDIFNRTGHQ------------------------ 170

  Fly   219 TPNCSDMFVSCRIAGRLFDC-MDKFETTLTSHGFCCTFNYDGRYVNKRDFRQRYFGPDMGLVLTL 282
               ..:|..||..:|:  :| .:.|....|.:|.|.|||  |.....|..:|...|..:.::|.:
Zfish   171 ---LEEMLKSCNFSGQ--NCSAEDFTVVYTRYGKCYTFN--GNKTTSRKTKQGGMGNGLEIMLDI 228

  Fly   283 KTDPSDNFYK------------INGHNGYPDPFSGGVAERVAETGFNTLLPVRAKIFETLPEARS 335
            :.|.....:|            :..|:....|:...:...|: .||.|.:..:.:....||:
Zfish   229 QQDDYLPIWKETNETSLEAGIRVQIHSQDEPPYIHQLGFGVS-PGFQTFVSCQEQRLTYLPQ--- 289

  Fly   336 MSPSVRKCLFENEMPWIFARH-----------YTFSKCISACRAQSVVSLCECVPFSLPHRYIDG 389
                          ||...|.           |:.|.|...|....|:..|:|....:|
Zfish   290 --------------PWGNCRSTSEQMIPGYDTYSISACRLRCETLEVLRECKCRMVHMP------ 334

  Fly   390 SEKRIYCTLQHLACLKRYEFKWLNVITSRENVTGLEHELQDALYCPLCLASCTETRYSVRGAMTL 454
            .:..| ||...:.|:.:             .:..|:....|..:|.   ..|..|||....:|
Zfish   335 GDANI-CTPSDIKCVDK-------------ALALLQKSSGDTCFCE---TPCNLTRYGKELSM-- 380

  Fly   455 GLPTPSQIKGPARSNPGPRANNSYGPASSSGSAKGPVHSSSAPAELAVVRIYFAETHIQYFRQII 519
             :..||  ||.||..                |.|.............|:.|:|...:.:...|
Zfish   381 -VKIPS--KGSARYL----------------SRKYDKSEDYIRDNFLVLDIFFEALNYETIEQ-- 424

  Fly   520 KSAWYETFSTIGNI---CGIIAGFSLIGICELLFFL 552
            |.| |:....:|:|   .|:..|.|::.|.|:|.::
Zfish   425 KKA-YDVAGLLGDIGGQMGLFIGASVLTILEILDYV 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:279230	104/522 (20%)
asic4a	NP_999952.1	ASC	44..472	CDD:295594	107/533 (20%)
asic4a	NP_999952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586584
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850