Protein Alignment ppk24 and asic4b

DIOPT Version :10

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_999951.1
• Gene: asic4b / 407667
• ZFINID: ZDB-GENE-040513-6
• Length: 558
• Species: Danio rerio
• Alignment Length: 636
• Identity: 128/636 - (20%)
• Similarity: 218/636 - (34%)
• Gaps: 204/636 - (32%)

  Fly    46 GTSAED---TRKLSFAAALKDLLQNLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFLW-G 106
            ||...|   .|:....|.|.....:.|.|..::.:.:..|:  .|...::.:..|..|..||: .
Zfish    26 GTGMLDEGLRRQKEGMADLASFASSSSLHGLARALGTSERL--GFRQTLWGLALLVSLGLFLYQA 88

  Fly   107 TYTKEQEALVTTMYHPMYPIWKVE------FPAISVCSLNRISQRAAWQ----YAHNLSGKDPKQ 161
            |:     :..|.:..|.....:.|      ||||::|::||....|...    :..||:|..||.
Zfish    89 TW-----SAATYLERPHLAALREETRRELTFPAITLCNVNRFRFSALTDADIYHLANLTGLPPKS 148

  Fly   162 RNASHFYDQLKAFMYMYYDPSDLMDIDNALRFQSFLDRFDTAKEELFFNTRNRMSALTPNCSDMF 226
            |. .|...:|:      |.|.:::||                    |..|.:::       .||.
Zfish   149 RK-GHRPSELQ------YPPPNMLDI--------------------FQRTGHQL-------EDML 179

  Fly   227 VSCRIAGRLFDC-MDKFETTLTSHGFCCTFNYDGRYVNKRDFRQRYFGPDMGLVLTLKTD----- 285
            .||..:|:  :| .:.|....|.:|.|.|||  |...:.:..||...|..:.::|.::.|
Zfish   180 KSCNFSGQ--NCSSEDFSVVYTRYGKCYTFN--GNKTSPKRVRQGGTGNGLEMMLDIQQDEYLPI 240

  Fly   286 -------PSDNFYKINGHNGYPDPFSGGVAERVAETGFNTLLPVRAKIFETLPEARSMSPSVRKC 343
                   ..:...::..|:....|:...:...|: .||.|.:..:.:....||:
Zfish   241 WRETNETTLEAGIRVQIHSQNEPPYIHQLGFGVS-PGFQTFVSCQEQRLTYLPQ----------- 293

  Fly   344 LFENEMPWIFAR-----------HYTFSKCISACRAQSVVSLCECVPFSLPHRYIDGSEKRIYCT 397
                  ||...|           .|:.|.|...|.:..|...|.|....:|     |...  .|.
Zfish   294 ------PWGNCRASSEPVIPGYDTYSVSACRLHCESTQVQRECNCRMVHMP-----GDAD--ICA 345

  Fly   398 LQHLACLKRYEFKWLNVITSRENVTGLEHELQDALYCPLCLASCTETRYSVRGAMTLGLPTPSQI 462
            ...:.|:.:       .:.|.:..||      |:  || |...|..|||....:|         :
Zfish   346 PSKIKCVDK-------ALASLQKSTG------DS--CP-CETPCNLTRYGKELSM---------V 385

  Fly   463 KGPARSNPGPRANNSYGPASSSGSAKGPVHSSSAPAE-----LAVVRIYFAETHIQYFRQIIKSA 522
            |.|:|                 |||:..........|     ..::.|:|...:.:...|  |.|
Zfish   386 KIPSR-----------------GSARYLSRKYQKSEEYIRDNFLILDIFFEALNYETIEQ--KKA 431

  Fly   523 WYETFSTIGNI---CGIIAGFSLIGICELLFFL-------AKQLWQACRAE-------------- 563
             |:....:|:|   .|:..|.|::.|.|:|.::       .|||.:..:::
Zfish   432 -YDIAGLLGDIGGQMGLFIGASILTILEILDYIYEVAKNKIKQLLKPKKSQKQTNQRNLIQEQIQ 495

  Fly   564 ---------LRAELA----------HIHVQIRNAQVAEPEAERPMKLFILP 595
                     |:|:|.          .:.|:..| .||:|.:..|..  :||
Zfish   496 RTKNLREQNLKAQLTAGAIATVRFEEVKVKAAN-DVAQPHSAHPTS--VLP 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:459966	108/528 (20%)
asic4b	NP_999951.1	ENaC	54..497	CDD:273304	110/557 (20%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	450..452		1/1 (100%)