Protein Alignment ppk24 and ASIC2

DIOPT Version :10

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 135/613 - (22%)
• Similarity: 216/613 - (35%)
• Gaps: 193/613 - (31%)

  Fly    18 GRAAWWIPNPG--RVARYPPIRTLAPNHL------------------PGTSAEDTRKLSFAAALK 62
            |..|..:..||  |:||..|    ||..|                  ||.:......||.|.
Human     8 GLPAAALTGPGRFRMAREEP----APAALAAAGQPGGGRGGERALQGPGVARRGRPSLSRAK--- 65

  Fly    63 DLLQNLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFLWGTYTKEQEALVTTMYHP----M 123
              |..|...|..: ..:|...|.|..|.:...|:..:|::  |.:     ..|:..:..|    :
Human    66 --LHGLRHMCAGR-TAAGGSFQRRALWVLAFCTSFGLLLS--WSS-----NRLLYWLSFPSHTRV 120

  Fly   124 YPIW--KVEFPAISVCSLN-----RISQRAAWQYAH-----------------NLSGKDPKQRNA 164
            :..|  ::.|||::||:.|     |:|:...:...|                 .|.|.:|:::
Human   121 HREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQ-- 183

  Fly   165 SHFYDQLKAFMYMYYDPSDLMDIDNALRFQSFLDRFDTAKEELFFNTRNRMSALTPNCSDMFVSC 229
              ::.:|..|. ::..|.....|..|     |:||                  |.....||.:||
Human   184 --WFRKLADFR-LFLPPRHFEGISAA-----FMDR------------------LGHQLEDMLLSC 222

  Fly   230 RIAGRLFDC-MDKFETTLTSHGFCCTFN--YDGRYVNKR-------------DFRQRYFGPDMGL 278
            :..|.|  | ...|.:..|.:|.|..||  .||:.:...             |.:|..:.|..|
Human   223 KYRGEL--CGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWG- 284

  Fly   279 VLTLKTDPS--DNFYKINGHNGYPDPFSGGVAERVAETGFNTLLPVRAKIFETLP----EARSMS 337
                :|:.:  :...|:..|:....||...:...|| .||.|.:..:.:....||    |.||
Human   285 ----ETEETTFEAGVKVQIHSQSEPPFIQELGFGVA-PGFQTFVATQEQRLTYLPPPWGECRS-- 342

  Fly   338 PSVRKCLFENEMPWIFARHYTFSKCISACRAQSVVSLCEC----VPFSLPHRYIDGSEKRIYCT- 397
                     :||...|...|:.:.|...|..:.:|..|.|    :|...|           :||
Human   343 ---------SEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAP-----------FCTP 387

  Fly   398 LQHLACLKRYEFKWLNVITSRENVTGLEHELQDALYCPLCLASCTETRYSVRGAMTLGLPTPSQI 462
            .||..|              .|...||..| :|:.|| ||...|..|||:...:|         :
Human   388 EQHKEC--------------AEPALGLLAE-KDSNYC-LCRTPCNLTRYNKELSM---------V 427

  Fly   463 KGPARSNPGPRANNSYGPASSSGSAKGPVHSSSAPAELAVVRIYFAETHIQYFRQIIKSAWYETF 527
            |.|::::.      .|.....:.|.|      .....:.|:.|:|...:.:...|  |.| ||..
Human   428 KIPSKTSA------KYLEKKFNKSEK------YISENILVLDIFFEALNYETIEQ--KKA-YEVA 477

  Fly   528 STIGNI---CGIIAGFSLIGICELLFFL 552
            :.:|:|   .|:..|.|::.|.||..::
Human   478 ALLGDIGGQMGLFIGASILTILELFDYI 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:459966	119/543 (22%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	120/553 (22%)