Protein Alignment ppk24 and Scnn1b

DIOPT Version :9

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_036780.1
• Gene: Scnn1b / 24767
• RGDID: 3640
• Length: 638
• Species: Rattus norvegicus
• Alignment Length: 693
• Identity: 126/693 - (18%)
• Similarity: 210/693 - (30%)
• Gaps: 284/693 - (40%)

  Fly    62 KDLL----QNLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFL----WGTYTKEQEALVTT 118
            |:||    .|.:.|...:::..|.:  ::..||:     ||:|.|.|    ||.:.:
  Rat    23 KELLVWYCNNTNTHGPKRIICEGPK--KKAMWFL-----LTLLFACLVCWQWGVFIQ-------- 72

  Fly   119 MYHPMYPIWKV-----------EFPAISVCSLNRISQRAAWQYA---HNLSGKDPKQRNASHFYD 169
                .|..|:|           .|||::||:      .:.:||:   |.|  ||        .|.
  Rat    73 ----TYLSWEVSVSLSMGFKTMNFPAVTVCN------SSPFQYSKVKHLL--KD--------LYK 117

  Fly   170 QLKAFMYMYYDP-SDLMDIDNALRFQSF----LDRFDTAKEE------LFFNTRNRMSALTPNCS 223
            .::|.:.....| |...:..:.|.|..:    |...|....:      ||.::.| .|...|..:
  Rat   118 LMEAVLDKILAPKSSHTNTTSTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHN-SSNPAPGST 181

  Fly   224 DMFVSCRIAGRLFDCMDKFETTLTSHGFCCTF-NYDG-----------------RYVNKRDFRQR 270
            .....|::|.||  |        :::|..||| |:..                 ..|..:|....
  Rat   182 CNAQGCKVAMRL--C--------SANGTVCTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGM 236

  Fly   271 YFGPDMGLVLTL-KTDPSD--NFYKINGHNGYPD-----PFSGGVAERV-------AETGFNTLL 320
            .:.||..::..| .|:|..  ||..|    .|||     .|:.|:.|:.       .|.|...:|
  Rat   237 GYAPDRIILACLFGTEPCSHRNFTPI----FYPDYGNCYIFNWGMTEKALPSANPGTEFGLKLIL 297

  Fly   321 PVRAKIFETLPEARSMSPSVRKCLFENEMPWIFARH----------------------------- 356
            .:..:  :.:|...|.:.:  :.:...:..:.|.|.
  Rat   298 DIGQE--DYVPFLASTAGA--RLMLHEQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPYSP 358

  Fly   357 --------------------YTFSKCISACRAQSVVSLCECVPFSLPHRYIDGSEKRIYCTLQHL 401
                                |:...|:.:|....::..|.|..:..|   :...||  ||.
  Rat   359 CTMNGSDVAIQNLYSDYNTTYSIQACLHSCFQDHMIHNCSCGHYLYP---LPAGEK--YCN---- 414

  Fly   402 ACLKRYEFKWLNVITSRENVTGLEHELQDALYC---------------PLCLASCTETRYSVRGA 451
                                   ..:..|..||               .:|..||.:|:|.:
  Rat   415 -----------------------NRDFPDWAYCYLSLQMSVVQRETCLSMCKESCNDTQYKM--- 453

  Fly   452 MTLGLPTPSQIKGPARSNPG--------PRANNSYGPASSSGSAKGPVHSSSAPAELAVVRIYFA 508
                  |.|....|:.::..        .|..:|....|..|..|              :.|||.
  Rat   454 ------TISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVK--------------LNIYFQ 498

  Fly   509 ETHIQYFRQIIKS-----AWYETFSTIGNICGIIAGFSLIGICELLFFLAKQLW-------QACR 561
            |.:   :|.|.:|     .|  ..|.:|...|...|.|::.:.|....:...:|       .:|:
  Rat   499 EFN---YRTIEESPANNIVW--LLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITVIKLVASCK 558

  Fly   562 AELR--------------AELAHIHVQIRNAQVAEPEAE--RP 588
            ...|              |||...|...    |.:|:..  ||
  Rat   559 GLRRRRPQRPYTGPPPTVAELVEAHTNC----VFQPDTTSCRP 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:279230	113/628 (18%)
Scnn1b	NP_036780.1	ENaC	21..621	CDD:273304	126/693 (18%)
		deg-1	29..538	CDD:273309	111/622 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..620		126/693 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345606
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750