DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk24 and Scnn1b

DIOPT Version :10

Sequence 1:NP_651860.2 Gene:ppk24 / 43702 FlyBaseID:FBgn0039839 Length:595 Species:Drosophila melanogaster
Sequence 2:NP_036780.1 Gene:Scnn1b / 24767 RGDID:3640 Length:638 Species:Rattus norvegicus


Alignment Length:693 Identity:126/693 - (18%)
Similarity:210/693 - (30%) Gaps:284/693 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 KDLL----QNLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFL----WGTYTKEQEALVTT 118
            |:||    .|.:.|...:::..|.:  ::..||:     ||:|.|.|    ||.:.:        
  Rat    23 KELLVWYCNNTNTHGPKRIICEGPK--KKAMWFL-----LTLLFACLVCWQWGVFIQ-------- 72

  Fly   119 MYHPMYPIWKV-----------EFPAISVCSLNRISQRAAWQYA---HNLSGKDPKQRNASHFYD 169
                .|..|:|           .|||::||:      .:.:||:   |.|  ||        .|.
  Rat    73 ----TYLSWEVSVSLSMGFKTMNFPAVTVCN------SSPFQYSKVKHLL--KD--------LYK 117

  Fly   170 QLKAFMYMYYDP-SDLMDIDNALRFQSF----LDRFDTAKEE------LFFNTRNRMSALTPNCS 223
            .::|.:.....| |...:..:.|.|..:    |...|....:      ||.::.| .|...|..:
  Rat   118 LMEAVLDKILAPKSSHTNTTSTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHN-SSNPAPGST 181

  Fly   224 DMFVSCRIAGRLFDCMDKFETTLTSHGFCCTF-NYDG-----------------RYVNKRDFRQR 270
            .....|::|.||  |        :::|..||| |:..                 ..|..:|....
  Rat   182 CNAQGCKVAMRL--C--------SANGTVCTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGM 236

  Fly   271 YFGPDMGLVLTL-KTDPSD--NFYKINGHNGYPD-----PFSGGVAERV-------AETGFNTLL 320
            .:.||..::..| .|:|..  ||..|    .|||     .|:.|:.|:.       .|.|...:|
  Rat   237 GYAPDRIILACLFGTEPCSHRNFTPI----FYPDYGNCYIFNWGMTEKALPSANPGTEFGLKLIL 297

  Fly   321 PVRAKIFETLPEARSMSPSVRKCLFENEMPWIFARH----------------------------- 356
            .:..:  :.:|...|.:.:  :.:...:..:.|.|.                             
  Rat   298 DIGQE--DYVPFLASTAGA--RLMLHEQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPYSP 358

  Fly   357 --------------------YTFSKCISACRAQSVVSLCECVPFSLPHRYIDGSEKRIYCTLQHL 401
                                |:...|:.:|....::..|.|..:..|   :...||  ||.    
  Rat   359 CTMNGSDVAIQNLYSDYNTTYSIQACLHSCFQDHMIHNCSCGHYLYP---LPAGEK--YCN---- 414

  Fly   402 ACLKRYEFKWLNVITSRENVTGLEHELQDALYC---------------PLCLASCTETRYSVRGA 451
                                   ..:..|..||               .:|..||.:|:|.:   
  Rat   415 -----------------------NRDFPDWAYCYLSLQMSVVQRETCLSMCKESCNDTQYKM--- 453

  Fly   452 MTLGLPTPSQIKGPARSNPG--------PRANNSYGPASSSGSAKGPVHSSSAPAELAVVRIYFA 508
                  |.|....|:.::..        .|..:|....|..|..|              :.|||.
  Rat   454 ------TISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVK--------------LNIYFQ 498

  Fly   509 ETHIQYFRQIIKS-----AWYETFSTIGNICGIIAGFSLIGICELLFFLAKQLW-------QACR 561
            |.:   :|.|.:|     .|  ..|.:|...|...|.|::.:.|....:...:|       .:|:
  Rat   499 EFN---YRTIEESPANNIVW--LLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITVIKLVASCK 558

  Fly   562 AELR--------------AELAHIHVQIRNAQVAEPEAE--RP 588
            ...|              |||...|...    |.:|:..  ||
  Rat   559 GLRRRRPQRPYTGPPPTVAELVEAHTNC----VFQPDTTSCRP 597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk24NP_651860.2 ASC 65..551 CDD:459966 113/628 (18%)
Scnn1bNP_036780.1 ENaC 21..621 CDD:273304 126/693 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..620 126/693 (18%)
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844 614..618
Blue background indicates that the domain is not in the aligned region.

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