Protein Alignment ppk24 and Scnn1b

DIOPT Version :9

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_001258952.1
• Gene: Scnn1b / 20277
• MGIID: 104696
• Length: 638
• Species: Mus musculus
• Alignment Length: 662
• Identity: 129/662 - (19%)
• Similarity: 208/662 - (31%)
• Gaps: 252/662 - (38%)

  Fly    62 KDLL----QNLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFL----WGTYTKEQEALVTT 118
            |:||    .|.:.|...:::..|.:  ::..||:     ||:|.|.|    ||.:.:
Mouse    23 KELLVWYCNNTNTHGPKRIICEGPK--KKAMWFL-----LTLLFACLVCWQWGVFIQ-------- 72

  Fly   119 MYHPMYPIWKV-----------EFPAISVCSLNRISQRAAWQYA---HNLSGKDPKQR------- 162
                .|..|:|           .|||::||:      .:.:||:   |.|...|....
Mouse    73 ----TYLSWEVSVSLSMGFKTMNFPAVTVCN------SSPFQYSKVKHLLKDLDELMEAVLEKIL 127

  Fly   163 --NASHF-YDQLKAFMYMYYDPSDLMD---IDNALRFQSFLDRFDTAKEELFFNTRNRMSALTPN 221
              .|||. ..:...|....:.|..|:|   .|:.:....|.|.         .|:.|.....|.|
Mouse   128 APEASHSNTTRTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDS---------HNSSNPAPGSTCN 183

  Fly   222 CSDMFVSCRIAGRLFDCMDKFETTLTSHGFCCTF-NYDG-----------------RYVNKRDFR 268
            ..    .|::|.||  |        :::|..||. |:..                 ..|..:|..
Mouse   184 AQ----GCKVAMRL--C--------SANGTVCTLRNFTSATQAVTEWYILQATNIFSQVLPQDLV 234

  Fly   269 QRYFGPDMGLVLTL-KTDPSD--NFYKINGHNGYPD-----PFSGGVAERV-------AETGFNT 318
            ...:.||..::..| .|:|..  ||..|    .|||     .|:.|:.|..       .|.|...
Mouse   235 GMGYAPDRIILACLFGTEPCSHRNFTPI----FYPDYGNCYIFNWGMTEETLPSANPGTEFGLKL 295

  Fly   319 LLPV---------------RAKIFE--TLPEAR------------SMSPSVRKCLFENEMPW--- 351
            :|.:               |..:.|  |.|..|            |:...|.|...:.| |:
Mouse   296 ILDIGQEDYVPFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLVDKLQRKGE-PYSPC 359

  Fly   352 --------------IFARHYTFSKCISACRAQSVVSLCECVPFSLPHRYIDGSEKRIYCTLQHLA 402
                          ::...|:...|:.:|....::..|.|..:..|   :...||  ||..:.
Mouse   360 TMNGSDVAIKNLYSVYNTTYSIQACLHSCFQDHMIRNCSCGHYLYP---LPEGEK--YCNNRD-- 417

  Fly   403 CLKRYEFKWLNV---ITSRENVTGLEHELQDALYCPLCLASCTETRYSVRGAMTLGLPTPSQIKG 464
             ...:.:.:||:   :|.||....            :|..||.:|:|.:         |.|....
Mouse   418 -FPDWAYCYLNLQMSVTQRETCLS------------MCKESCNDTQYKM---------TISMADW 460

  Fly   465 PARSNPG--------PRANNSYGPASSSGSAKGPVHSSSAPAELAVVRIYFAETHIQYFRQIIKS 521
            |:.::..        .|..:|....|..|..|              :.|||.|.:   :|.|.:|
Mouse   461 PSEASEDWILHVLSQERDQSSNITLSRKGIVK--------------LNIYFQEFN---YRTIEES 508

  Fly   522 -----AWYETFSTIGNICGIIAGFSLIGICELLFFLAKQLW-------QACRAELR--------- 565
                 .|  ..|.:|...|...|.|::.:.|....:...:|       .:|:...|
Mouse   509 PANNIVW--LLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITIIKLVASCKGLRRRRPQAPYTG 571

  Fly   566 -----AELAHIH 572
                 |||...|
Mouse   572 PPPTVAELVEAH 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:279230	120/615 (20%)
Scnn1b	NP_001258952.1	ENaC	21..621	CDD:273304	129/662 (19%)
		deg-1	29..538	CDD:273309	118/609 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..620

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842176
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750