Protein Alignment ppk24 and Scnn1a

DIOPT Version :9

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_035454.2
• Gene: Scnn1a / 20276
• MGIID: 101782
• Length: 700
• Species: Mus musculus
• Alignment Length: 660
• Identity: 131/660 - (19%)
• Similarity: 223/660 - (33%)
• Gaps: 204/660 - (30%)

  Fly     2 PVEMESLDQ--KPFRLAVGRAAWWIPNPGRVARYPPIRTLAPNHLPGTSAEDTRKLSFAAALKDL 64
            |:.|:.|.:  |....|:|      |.|.. .|.|             :.|:...:.|..:.::|
Mouse    40 PLPMQGLGKGDKREEQALG------PEPSE-PRQP-------------TEEEEALIEFHRSYREL 84

  Fly    65 LQ----NLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFLWGTYTKEQEALVTTMYHPMYP 125
            .|    |.:.|...:||.|.....:..||.|..:....::   .|      |.||:...|. .||
Mouse    85 FQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMM---YW------QFALLFEEYF-SYP 139

  Fly   126 IW--------KVEFPAISVCSLN---------------RISQRAAWQ-YAHN------------- 153
            :.        |:.|||::||:||               ||:::..:. |.:|
Mouse   140 VSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTLFDLYKYNSSYTRQAGGRRRS 204

  Fly   154 ---LSGKDP----------------KQRNASHFY----------DQLKAFMYMYYDPSDLMDIDN 189
               |.|..|                ..|:||...          |....|.....:.||..
Mouse   205 TRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDNNPQVDRKDWKIGFQLCNQNKSDCF---- 265

  Fly   190 ALRFQSFLDRFDTAKEELFFNTRNRMSALTPNCSDMFVSCRIAGRLFDC-----------MDKFE 243
               :|::....|..:|...|:..|.:|.| |:.|.......:...:|.|           ..:|.
Mouse   266 ---YQTYSSGVDAVREWYRFHYINILSRL-PDTSPALEEEALGSFIFTCRFNQAPCNQANYSQFH 326

  Fly   244 TTLTSHGFCCTFNYDGRYVNKRD---FRQRYFGPDMGLVLTLKTDPSD---NFYKINGH----NG 298
            ..:  :|.|.|||      ||.:   :.....|.:.||.|||:|:.:|   ....:.|.    :|
Mouse   327 HPM--YGNCYTFN------NKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHG 383

  Fly   299 YPDPF---SGGVAERVAETGFNTLLPVRAKIFETLPEARSMSPSVRKCLFEN--EMPW--IFARH 356
            ..:|.   .||...|   .|..|.:.:|.:..:      |:..:...|. ||  ::|.  ::...
Mouse   384 QDEPAFMDDGGFNVR---PGVETSISMRKEALD------SLGGNYGDCT-ENGSDVPVKNLYPSK 438

  Fly   357 YTFSKCISACRAQSVVSLCECVPFSLPHRYIDGSEKRIYCTLQHLACLKRYEFKWLNVITSRENV 421
            ||...||.:|..::::..|.|.....|..  .|.|   :|..     ||:..:.:
Mouse   439 YTQQVCIHSCFQENMIKKCGCAYIFYPKP--KGVE---FCDY-----LKQSSWGY---------- 483

  Fly   422 TGLEHELQ-----DALYC-PLCLASCTETRYSVRGAMTLGLPTPSQIKGPARSNPGPRANNSYGP 480
              ..::||     |:|.| ..|...|:.|.|.    ::.|......:|............|:|
Mouse   484 --CYYKLQAAFSLDSLGCFSKCRKPCSVTNYK----LSAGYSRWPSVKSQDWIFEMLSLQNNY-- 540

  Fly   481 ASSSGSAKGPVHSSSAPAELAVVRIYFAETHIQYFRQIIKSAWYETFSTIGNICGIIAGFSLIGI 545
             :.:....|          :|.:.|:|.|.:.:...:..........|.:|:...:..|.|::.:
Mouse   541 -TINNKRNG----------VAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSV 594

  Fly   546 ---CELLFFL 552
               .||:|.|
Mouse   595 VEMAELIFDL 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:279230	116/592 (20%)
Scnn1a	NP_035454.2	ENaC	80..677	CDD:273304	119/600 (20%)
		deg-1	88..600	CDD:273309	113/586 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842186
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750