Protein Alignment ppk24 and Scnn1a

DIOPT Version :10

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_035454.3
• Gene: Scnn1a / 20276
• MGIID: 101782
• Length: 699
• Species: Mus musculus
• Alignment Length: 660
• Identity: 131/660 - (19%)
• Similarity: 223/660 - (33%)
• Gaps: 204/660 - (30%)

  Fly     2 PVEMESLDQ--KPFRLAVGRAAWWIPNPGRVARYPPIRTLAPNHLPGTSAEDTRKLSFAAALKDL 64
            |:.|:.|.:  |....|:|      |.|.. .|.|             :.|:...:.|..:.::|
Mouse    39 PLPMQGLGKGDKREEQALG------PEPSE-PRQP-------------TEEEEALIEFHRSYREL 83

  Fly    65 LQ----NLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFLWGTYTKEQEALVTTMYHPMYP 125
            .|    |.:.|...:||.|.....:..||.|..:....::   .|      |.||:...|. .||
Mouse    84 FQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMM---YW------QFALLFEEYF-SYP 138

  Fly   126 IW--------KVEFPAISVCSLN---------------RISQRAAWQ-YAHN------------- 153
            :.        |:.|||::||:||               ||:::..:. |.:|
Mouse   139 VSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTLFDLYKYNSSYTRQAGGRRRS 203

  Fly   154 ---LSGKDP----------------KQRNASHFY----------DQLKAFMYMYYDPSDLMDIDN 189
               |.|..|                ..|:||...          |....|.....:.||..
Mouse   204 TRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDNNPQVDRKDWKIGFQLCNQNKSDCF---- 264

  Fly   190 ALRFQSFLDRFDTAKEELFFNTRNRMSALTPNCSDMFVSCRIAGRLFDC-----------MDKFE 243
               :|::....|..:|...|:..|.:|.| |:.|.......:...:|.|           ..:|.
Mouse   265 ---YQTYSSGVDAVREWYRFHYINILSRL-PDTSPALEEEALGSFIFTCRFNQAPCNQANYSQFH 325

  Fly   244 TTLTSHGFCCTFNYDGRYVNKRD---FRQRYFGPDMGLVLTLKTDPSD---NFYKINGH----NG 298
            ..:  :|.|.|||      ||.:   :.....|.:.||.|||:|:.:|   ....:.|.    :|
Mouse   326 HPM--YGNCYTFN------NKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHG 382

  Fly   299 YPDPF---SGGVAERVAETGFNTLLPVRAKIFETLPEARSMSPSVRKCLFEN--EMPW--IFARH 356
            ..:|.   .||...|   .|..|.:.:|.:..:      |:..:...|. ||  ::|.  ::...
Mouse   383 QDEPAFMDDGGFNVR---PGVETSISMRKEALD------SLGGNYGDCT-ENGSDVPVKNLYPSK 437

  Fly   357 YTFSKCISACRAQSVVSLCECVPFSLPHRYIDGSEKRIYCTLQHLACLKRYEFKWLNVITSRENV 421
            ||...||.:|..::::..|.|.....|..  .|.|   :|..     ||:..:.:
Mouse   438 YTQQVCIHSCFQENMIKKCGCAYIFYPKP--KGVE---FCDY-----LKQSSWGY---------- 482

  Fly   422 TGLEHELQ-----DALYC-PLCLASCTETRYSVRGAMTLGLPTPSQIKGPARSNPGPRANNSYGP 480
              ..::||     |:|.| ..|...|:.|.|.    ::.|......:|............|:|
Mouse   483 --CYYKLQAAFSLDSLGCFSKCRKPCSVTNYK----LSAGYSRWPSVKSQDWIFEMLSLQNNY-- 539

  Fly   481 ASSSGSAKGPVHSSSAPAELAVVRIYFAETHIQYFRQIIKSAWYETFSTIGNICGIIAGFSLIGI 545
             :.:....|          :|.:.|:|.|.:.:...:..........|.:|:...:..|.|::.:
Mouse   540 -TINNKRNG----------VAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSV 593

  Fly   546 ---CELLFFL 552
               .||:|.|
Mouse   594 VEMAELIFDL 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:459966	116/592 (20%)
Scnn1a	NP_035454.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		11/51 (22%)
		ENaC	79..676	CDD:273304	119/600 (20%)
		Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000305|PubMed:18650438	200..270		11/76 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..244		4/32 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..699
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P37088	669..673