DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk24 and asic-2

DIOPT Version :9

Sequence 1:	NP_651860.2	Gene:	ppk24 / 43702	FlyBaseID:	FBgn0039839	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_492099.1	Gene:	asic-2 / 189058	WormBaseID:	WBGene00012137	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	511	Identity:	102/511 - (19%)
Similarity:	174/511 - (34%)	Gaps:	121/511 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 RFFWFVFHITALTVLIAFLWGTYTKEQEALVTTMYHPMYP--------IWKVEFPAISVCSLNR- 141
            |.||.        .:..|:.|.:..|...|:...:  .||        ..|..||.::||::|.
Worm    34 RIFWI--------AIFLFVLGMFAYELYILIAKFF--SYPATVNTEILFEKQIFPVVTVCNMNPY 88

  Fly   142 ----ISQRAAWQYAHNLSGKDPKQRNASHFYDQLKAFMYMYYDPSDLMDID----NALRFQSFLD 198
                :...:|:...:.|..........:...|:    ..:|.|..:..|:|    :||..::.|.
Worm    89 KYSVVKSNSAFSSVNTLMTTYSDATVGTFSTDK----WGLYADNDETYDLDSRAADALVLEANLI 149

  Fly   199 RFDTAKEELFFNTRNRMSALTPNCSDMFVSCRIAGRLFDCMDKFETTLTS--HGFCCTFNYDG-- 259
            . ||||....:           ..:|:...|..||  ..|.:...|....  :|.|.:||.|.
Worm   150 S-DTAKVPALY-----------TYADLIQDCSFAG--IPCSESDFTKFIDPVYGACYSFNEDASL 200

  Fly   260 RYVNKRDFRQRYFGPDMGLVLT-LKTDPSDNFYK----------INGHNGYPDPFSGGVAERVA- 312
            .|...|:..|  ||..:.|.:| .||:.:.:...          :|.....|...|.|:...|.
Worm   201 NYSVSREGIQ--FGLKLMLTVTQTKTNGNTDSLPTTKLAGARIGVNSRGSSPGLDSNGIDAGVGY 263

  Fly   313 ETGFNTLLP--VRA-KIFETLPEARSMSPSVRKCLFENEMPWIFARHYTFSKCISACRAQSVVSL 374
            |:..:..|.  ||| |.:.|..:....|....|...           ||...|.:.|:.:..::.
Worm   264 ESAVSVSLTQNVRAKKPYGTCVDREPDSSDYYKDFI-----------YTLETCFNGCKQRDTIAK 317

  Fly   375 CECVPFSLPHRYIDGSEKRIYCTLQHLACLKRYEFKWLNVITSRENVTGLEHELQDALYCPLCLA 439
            |:|....|.....|.:.:.|...|..|..||.      |..:|..|:        |.|....|..
Worm   318 CQCANPRLALGSTDTACQPIKADLDCLQTLKG------NQTSSTPNI--------DLLVECNCNP 368

  Fly   440 SCTETRYSVRGAMTLGLPTPSQIKGPARSNPGPRANNSYGPASSSGSAKGPVHSSSAPAEL---- 500
            .|.|:.|:         ||.|..:.|         :.||..|:||.:..|...|:::....
Worm   369 PCDESTYT---------PTVSLAQFP---------STSYYVATSSTAGVGSCSSTNSKFSSKSDC 415

  Fly   501 --------AVVRIYFAETHIQYFRQIIKSAWYETFSTIGNICGIIAGFSLIGICEL 548
                    .:::::......:.:.:..........:.:|...|:..|.|:|.:.|:
Worm   416 QKWYNNNGMIIQVFLETLSYELYTETAGYTVSNVINDLGGQAGLWLGLSVISVVEM 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:279230	102/511 (20%)
asic-2	NP_492099.1	deg-1	12..474	CDD:273309	102/511 (20%)
asic-2	NP_492099.1	ASC	13..471	CDD:279230	101/509 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820