Protein Alignment ppk24 and Asic1

DIOPT Version :10

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_001276720.1
• Gene: Asic1 / 11419
• MGIID: 1194915
• Length: 559
• Species: Mus musculus
• Alignment Length: 545
• Identity: 110/545 - (20%)
• Similarity: 173/545 - (31%)
• Gaps: 179/545 - (32%)

  Fly    62 KDLL---QNLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFLWGTYTKEQEALVTTMYHPM 123
            :||:   .:.:.|..|.:...|.....:..|.|..:.||.   |||.....:       ..|:..
Mouse    61 RDLVAFANSCTLHGASHVFVEGGPGPRQALWAVAFVIALG---AFLCQVGDR-------VAYYLS 115

  Fly   124 YP---------IWKVEFPAISVCSLN--RISQRAAWQYAHNLSGKDPKQRNASHFYDQLKAFMYM 177
            ||         ..::.|||::.|:.|  |:||.:                    :.|.|.....:
Mouse   116 YPHVTLLDEVATTELVFPAVTFCNTNAVRLSQLS--------------------YPDLLYLAPML 160

  Fly   178 YYDPSDLMDIDNALRFQSFLDRFDTAKEELF----FNTRNRMSALTPNCSDMFVSCRIAGRLFDC 238
            ..|.||...:..|           ....|.|    ||.....:.......||.:.|...|.  .|
Mouse   161 GLDESDDPGVPLA-----------PPGPEAFSGEPFNLHRFYNRSCHRLEDMLLYCSYCGG--PC 212

  Fly   239 -MDKFETTLTSHGFCCTFN--YDGRYVNKR-------------DFRQRYFGPDMGLVLTLKTDPS 287
             ...|....|.:|.|.|||  .|||...|.             |.:|..:.|..|     :||.:
Mouse   213 GPHNFSVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWG-----ETDET 272

  Fly   288 --DNFYKINGHNGYPDPFSGGVAERVAETGFNTLLPVRAKIFETLPEARSMSPSVRKCLFENEMP 350
              :...|:..|:....||...:...|| .||.|.:..:.:....||.                 |
Mouse   273 SFEAGIKVQIHSQDEPPFIDQLGFGVA-PGFQTFVSCQEQRLIYLPS-----------------P 319

  Fly   351 W----------IFARHYTFSKCISACRAQSVVSLCEC--------VPFSLPHRYIDGSEKRIYCT 397
            |          .|...|:.:.|...|..:.:|..|.|        .|:..|.:|.:.::..:...
Mouse   320 WGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFL 384

  Fly   398 LQHLACLKRYEFKWLNVITSRENVTGLEHELQDALYCPLCLASCTETRYSVRGAMTLGLPTPSQI 462
            ::                             :|..|| :|...|..|||....:|         :
Mouse   385 VE-----------------------------KDQEYC-VCEMPCNLTRYGKELSM---------V 410

  Fly   463 KGPARSNPGPRANNSYGPASSSGSAKGPVHSSSAPAE-LAVVRIYFAETHIQYFRQIIKSAWYET 526
            |.|::             ||:...||....|.....| :.|:.|:|...:.:...|  |.| ||.
Mouse   411 KIPSK-------------ASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQ--KKA-YEI 459

  Fly   527 FSTIGNI---CGIIAGFSLIGICEL 548
            ...:|:|   .|:..|.|::.:.||
Mouse   460 AGLLGDIGGQMGLFIGASILTVLEL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:459966	108/542 (20%)
Asic1	NP_001276720.1	ENaC	63..541	CDD:273304	109/543 (20%)