Protein Alignment CAH6 and CA12

DIOPT Version :10

• Sequence 1: NP_001097987.1
• Gene: CAH6 / 43701
• FlyBaseID: FBgn0039838
• Length: 298
• Species: Drosophila melanogaster
• Sequence 2: NP_001209.1
• Gene: CA12 / 771
• HGNCID: 1371
• Length: 354
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 95/299 - (31%)
• Similarity: 142/299 - (47%)
• Gaps: 46/299 - (15%)

  Fly     9 LLLLLPLAYQHTSNDHKDESHWDY-ETNGQN-W-------GGICSTGERQSPISLNVQ----KSL 60
            :|||:.|..|.:|....:.|.|.| ..:|:| |       ||:.     ||||.|:..    .:.
Human    11 VLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLL-----QSPIDLHSDILQYDAS 70

  Fly    61 IVPLPRIVFGNYDVKLRGPLTLLNNGHTAHVEIPETANGNKPFITGGLLKGRFVAEAFHFHWGSP 125
            :.||.   |..|::.......|.||||:..:.:|...:     |.|  |:.|:.|...|.|||:|
Human    71 LTPLE---FQGYNLSANKQFLLTNNGHSVKLNLPSDMH-----IQG--LQSRYSATQLHLHWGNP 125

  Fly   126 SS-RGSEHSINQQRFDVEMHIVHRN-EKYGDIDEAKNKKDGIAVIGVMLKIVKNPNRIFPGLSKV 188
            :. .||||:::.|.|..|:||||.| :.|.|...|.||.:|:||:.|::::    ....|...|:
Human   126 NDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEM----GSFNPSYDKI 186

  Fly   189 MSALPRVTKYNAKTTIPGGLSLGQMLGNVNPRDFFTYRGSLTTPLCEQSVTWTVFSQVLPVPYSS 253
            .|.|..| ||..:.....|.::.::|.. ...:::.||||||||.|..:|.||||..  ||..|.
Human   187 FSHLQHV-KYKGQEAFVPGFNIEELLPE-RTAEYYRYRGSLTTPPCNPTVLWTVFRN--PVQISQ 247

  Fly   254 VSKF--------WKLRDSEGHRLINNFRDIQPRNGRPVF 284
            ....        ..:.|.....:|||||.:|..:.|.|:
Human   248 EQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVY 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH6	NP_001097987.1	Carb_anhydrase	26..287	CDD:459707	89/282 (32%)
CA12	NP_001209.1	alpha_CA_XII_XIV	39..289	CDD:239400	86/271 (32%)