Protein Alignment CAH6 and CA9

DIOPT Version :10

• Sequence 1: NP_001097987.1
• Gene: CAH6 / 43701
• FlyBaseID: FBgn0039838
• Length: 298
• Species: Drosophila melanogaster
• Sequence 2: NP_001207.2
• Gene: CA9 / 768
• HGNCID: 1383
• Length: 459
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 91/289 - (31%)
• Similarity: 133/289 - (46%)
• Gaps: 56/289 - (19%)

  Fly    19 HTSNDHKDESHWDYETNGQNWGG---------ICSTGERQSPISLNVQKSLIVPLPRIVFGNYDV 74
            |...:..|:|||.|       ||         .|: |..|||:.:..|.:...|..|      .:
Human   130 HRDKEGDDQSHWRY-------GGDPPWPRVSPACA-GRFQSPVDIRPQLAAFCPALR------PL 180

  Fly    75 KLRG-------PLTLLNNGHTAHVEIPETANGNKPFITGGLLKGR-FVAEAFHFHWGSPSSRGSE 131
            :|.|       .|.|.||||:..:.:|       |.:...|..|| :.|...|.|||:....|||
Human   181 ELLGFQLPPLPELRLRNNGHSVQLTLP-------PGLEMALGPGREYRALQLHLHWGAAGRPGSE 238

  Fly   132 HSINQQRFDVEMHIVHRNEKYGDIDEAKNKKDGIAVIGVMLKIVKNPNRIFPGLSKVMSALPRVT 196
            |::...||..|:|:||.:..:..:|||..:..|:||:...|:.....|..:   .:::|.|..:.
Human   239 HTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAY---EQLLSRLEEIA 300

  Fly   197 KYNAKTTIPGGLSLGQMLGNVNPRDF---FTYRGSLTTPLCEQSVTWTVFSQVLPVP----YSSV 254
            :..::|.:| ||.:..:|    |.||   |.|.||||||.|.|.|.||||:|.:.:.    ::..
Human   301 EEGSETQVP-GLDISALL----PSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS 360

  Fly   255 SKFWKLRDSEGHRLINNFRDIQPRNGRPV 283
            ...|...||   ||..|||..||.|||.:
Human   361 DTLWGPGDS---RLQLNFRATQPLNGRVI 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH6	NP_001097987.1	Carb_anhydrase	26..287	CDD:459707	90/282 (32%)
CA9	NP_001207.2	Proteoglycan-like (PG)	38..112
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..154		8/30 (27%)
		PHA03169	<44..>148	CDD:223003	8/24 (33%)
		Catalytic. /evidence=ECO:0000269|PubMed:19805286	138..391		89/281 (32%)
		alpha_CA_IX	145..391	CDD:239403	84/267 (31%)