Protein Alignment CAH6 and CA8

DIOPT Version :10

• Sequence 1: NP_001097987.1
• Gene: CAH6 / 43701
• FlyBaseID: FBgn0039838
• Length: 298
• Species: Drosophila melanogaster
• Sequence 2: NP_001399060.1
• Gene: CA8 / 767
• HGNCID: 1382
• Length: 306
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 97/305 - (31%)
• Similarity: 147/305 - (48%)
• Gaps: 50/305 - (16%)

  Fly    15 LAYQHTSNDHKDES---HWDYETNGQNWGGIC--STGERQSPISLNVQKSLIVP--LPRIVFGNY 72
            :|:.....|.::|.   .|.|| .|..||.:.  :.||.||||:||.:::...|  |...:..||
Human    11 VAFPEKEEDEEEEEEGVEWGYE-EGVEWGLVFPDANGEYQSPINLNSREARYDPSLLDVRLSPNY 74

  Fly    73 DVKLRGPLTLLNNGHTAHVEIPETANGNKPFITGGLLKGRFVAEAF--HFHWGSPSSRGSEHSIN 135
            .|.....:|  |:|||..|.:.     :|..::||.|......|.:  .||||..:.|||||::|
Human    75 VVCRDCEVT--NDGHTIQVILK-----SKSVLSGGPLPQGHEFELYEVRFHWGRENQRGSEHTVN 132

  Fly   136 QQRFDVEMHIVHRNEK-YGDIDEAKNKKDGIAVIGVMLKIVKNPNRIFPGLSKVMSALPRVTKYN 199
            .:.|.:|:|::|.|.. :|.||||..|..|||:|.:.::|.|.    ..||..|...|..: :|.
Human   133 FKAFPMELHLIHWNSTLFGSIDEAVGKPHGIAIIALFVQIGKE----HVGLKAVTEILQDI-QYK 192

  Fly   200 AKT-TIPGGLSLGQMLGNVNPRDFFTYRGSLTTPLCEQSVTWTVFSQVLPV-------------- 249
            .|: ||| ..:...:|.:...||::.|.||||.|.|.:.|||.:|...|.:
Human   193 GKSKTIP-CFNPNTLLPDPLLRDYWVYEGSLTIPPCSEGVTWILFRYPLTISQLQVWRMESGRKV 256

  Fly   250 --PYSSVSKFWKLRDS-EGHRLI--------NNFRDIQPRNGRPV 283
              |..|:.:|.:||.. :|..|:        :|||..||.:.|.:
Human   257 GMPVISIEEFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVI 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH6	NP_001097987.1	Carb_anhydrase	26..287	CDD:459707	95/294 (32%)
CA8	NP_001399060.1	alpha_CARP_VIII	35..305	CDD:239394	90/280 (32%)