Protein Alignment CAH6 and CA4

DIOPT Version :10

• Sequence 1: NP_001097987.1
• Gene: CAH6 / 43701
• FlyBaseID: FBgn0039838
• Length: 298
• Species: Drosophila melanogaster
• Sequence 2: XP_005257696.1
• Gene: CA4 / 762
• HGNCID: 1375
• Length: 336
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 93/312 - (29%)
• Similarity: 145/312 - (46%)
• Gaps: 47/312 - (15%)

  Fly     9 LLLLLPLAYQHTSNDHKDESHWDYETNGQN----------WGGICSTGERQSPISLNVQKSLI-V 62
            ||.||.|:....|  ...||||.||...::          |||.|.. :|||||::...|:.: .
Human     4 LLALLALSAARPS--ASAESHWCYEVQAESSNYPCLVPVKWGGNCQK-DRQSPINIVTTKAKVDK 65

  Fly    63 PLPRIVFGNYDVKLRGPLTLLNNGHTAHVEIPETANGNKPFITGGLLKGRFVAEAFHFHWGSPSS 127
            .|.|..|..||.|  ...|:.||||:..:.:.     ||..|:||.|...:.|:..|.||.....
Human    66 KLGRFFFSGYDKK--QTWTVQNNGHSVMMLLE-----NKASISGGGLPAPYQAKQLHLHWSDLPY 123

  Fly   128 RGSEHSINQQRFDVEMHIVHRNEK--YGDIDEAKNKKDGIAVIGVMLKI--------------VK 176
            :|||||::.:.|.:||||||..||  ..::.||::.:|.|||:..:::|              .:
Human   124 KGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEIGRMNWPPPLAPCRLSQ 188

  Fly   177 NPN-------RIFPGLSKVMSALPRVTKYNAKTTIPGGLSLGQMLGNVNPRDFFTYRGSLTTPLC 234
            :|:       ::..|...::.||..:.|....||:.....|..:......|.:|.|.||||||.|
Human   189 DPSLPFQAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTC 253

  Fly   235 EQSVTWTVFSQVLPVPYSSVSKFWKLRDSEGHRLI---NNFRDIQPRNGRPV 283
            ::.|.||||.:.:.:....:..|.:....:..:.:   :|.|.:|....|.|
Human   254 DEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTV 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH6	NP_001097987.1	Carb_anhydrase	26..287	CDD:459707	87/295 (29%)
CA4	XP_005257696.1	alpha_CA_IV_XV_like	48..307	CDD:239391	77/266 (29%)