Protein Alignment CAH6 and CA3

DIOPT Version :10

• Sequence 1: NP_001097987.1
• Gene: CAH6 / 43701
• FlyBaseID: FBgn0039838
• Length: 298
• Species: Drosophila melanogaster
• Sequence 2: NP_005172.1
• Gene: CA3 / 761
• HGNCID: 1374
• Length: 260
• Species: Homo sapiens
• Alignment Length: 276
• Identity: 87/276 - (31%)
• Similarity: 132/276 - (47%)
• Gaps: 47/276 - (17%)

  Fly    30 WDYET-NG-QNWGGIC--STGERQSPISLNVQKSLIVPLPRIVFGNYD---VKLRGPLTLLNNGH 87
            |.|.: || .:|..:.  :.||.|||:.|:.:.....|..:....:||   .|     |:||||.
Human     5 WGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAK-----TILNNGK 64

  Fly    88 TAHVEIPETANGNKPFITGGLLKGRFVAEAFHFHWGSPSSRGSEHSINQQRFDVEMHIVHRNEKY 152
            |..|...:|.  ::..:.||.|.|.:....||.||||....||||:::..::..|:|:||.|.||
Human    65 TCRVVFDDTY--DRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKY 127

  Fly   153 GDIDEAKNKKDGIAVIGVMLKI--VKNPNRIFPGLSKVMSALPRV---------TKYNAKTTIPG 206
            ....||..::|||||||:.|||  .....:||      :.||.::         ||::.....|.
Human   128 NTFKEALKQRDGIAVIGIFLKIGHENGEFQIF------LDALDKIKTKGKEAPFTKFDPSCLFPA 186

  Fly   207 GLSLGQMLGNVNPRDFFTYRGSLTTPLCEQSVTWTVFSQVLPVPYSSVSKFWKLRDSEGHR---- 267
                        .||::||:||.|||.||:.:.|.:..:.:.|....::|...|..|..:.
Human   187 ------------CRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVP 239

  Fly   268 LINNFRDIQPRNGRPV 283
            |::|:|..||.|.|.|
Human   240 LVSNWRPPQPINNRVV 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH6	NP_001097987.1	Carb_anhydrase	26..287	CDD:459707	87/276 (32%)
CA3	NP_005172.1	alpha_CA_I_II_III_XIII	1..259	CDD:239393	87/276 (32%)
		Involved in proton transfer. /evidence=ECO:0000269|PubMed:17427958	64..67		1/2 (50%)