Protein Alignment CAH6 and CA1

DIOPT Version :10

• Sequence 1: NP_001097987.1
• Gene: CAH6 / 43701
• FlyBaseID: FBgn0039838
• Length: 298
• Species: Drosophila melanogaster
• Sequence 2: NP_001729.1
• Gene: CA1 / 759
• HGNCID: 1368
• Length: 261
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 85/281 - (30%)
• Similarity: 132/281 - (46%)
• Gaps: 56/281 - (19%)

  Fly    30 WDY-ETNG-QNWGGI--CSTGERQSPISLNVQKSLIVPLPRIVFGNYDVKLR------GPLT--- 81
            |.| :.|| :.|..:  .:.|..|||:.:...::           .:|..|:      .|.|
Human     6 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSET-----------KHDTSLKPISVSYNPATAKE 59

  Fly    82 LLNNGHTAHVEIPETANGNKPFITGGLLKGRFVAEAFHFHWGSPSSRGSEHSINQQRFDVEMHIV 146
            ::|.||:.||...:  |.|:..:.||.....:....|||||||.:..||||:::..::..|:|:.
Human    60 IINVGHSFHVNFED--NDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVA 122

  Fly   147 HRNE-KYGDIDEAKNKKDGIAVIGVMLKIVKNPNRIFPGLSKVMSALPRV---------TKYNAK 201
            |.|. ||..:.||.:|.||:|||||::|:    ....|.|.||:.||..:         |.::..
Human   123 HWNSAKYSSLAEAASKADGLAVIGVLMKV----GEANPKLQKVLDALQAIKTKGKRAPFTNFDPS 183

  Fly   202 TTIPGGLSLGQMLGNVNPRDFFTYRGSLTTPLCEQSVTWTVFSQVLPVPYSSVSKFWKLRDS-EG 265
            |.:|..|            ||:||.||||.|...:||||.:..:.:.|....:::|..|..: ||
Human   184 TLLPSSL------------DFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEG 236

  Fly   266 HRLI---NNFRDIQPRNGRPV 283
            ...:   :|.|..||..||.|
Human   237 DNAVPMQHNNRPTQPLKGRTV 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH6	NP_001097987.1	Carb_anhydrase	26..287	CDD:459707	85/281 (30%)
CA1	NP_001729.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		7/24 (29%)
		alpha_CA	2..261	CDD:469577	85/281 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..261		7/17 (41%)