Protein Alignment CAH6 and CA14

DIOPT Version :10

• Sequence 1: NP_001097987.1
• Gene: CAH6 / 43701
• FlyBaseID: FBgn0039838
• Length: 298
• Species: Drosophila melanogaster
• Sequence 2: NP_036245.1
• Gene: CA14 / 23632
• HGNCID: 1372
• Length: 337
• Species: Homo sapiens
• Alignment Length: 288
• Identity: 95/288 - (32%)
• Similarity: 138/288 - (47%)
• Gaps: 40/288 - (13%)

  Fly    29 HWDYE-TNGQ-NWGGI---CSTGERQSPISLNVQKSLIVP-LPRIVFGNYDVKLRGPLTLLNNGH 87
            ||.|| .:|| :|...   |. ...||||.:........| ||.:....||.....||.|.||||
Human    21 HWTYEGPHGQDHWPASYPECG-NNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGH 84

  Fly    88 TAHVEIPETANGNKPFITGGLLKGRFVAEAFHFHWGSPSS-RGSEHSINQQRFDVEMHIVH-RNE 150
            |..:.:|.|      ...|||.: ::||...|.|||...| .||||.||.:....|:|||| .::
Human    85 TVQLSLPST------LYLGGLPR-KYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSD 142

  Fly   151 KYGDIDEAKNKKDGIAVIGVMLKIVKNPNRIFPGLSKVMSALPRVTKYNAKTTIPGGLSLGQMLG 215
            .|..:.||..:..|:||:|:::::.:..|..:   ..::|.|..|...:.||::| ..:|.::|
Human   143 SYDSLSEAAERPQGLAVLGILIEVGETKNIAY---EHILSHLHEVRHKDQKTSVP-PFNLRELL- 202

  Fly   216 NVNPR---DFFTYRGSLTTPLCEQSVTWTVFSQVLPVPYSSVSK----FWKLRDSEGHRLINNFR 273
               |:   .:|.|.||||||.|.|||.||||.:...:....:.|    .:...:.....|:.|:|
Human   203 ---PKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYR 264

  Fly   274 DIQPRNGRPVF---------YRIGKDLS 292
            .:||.|.|.||         |..|:.||
Human   265 ALQPLNQRMVFASFIQAGSSYTTGEMLS 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH6	NP_001097987.1	Carb_anhydrase	26..287	CDD:459707	92/281 (33%)
CA14	NP_036245.1	alpha_CA_XII_XIV	29..278	CDD:239400	87/264 (33%)