Protein Alignment chp and LRRC4B

DIOPT Version :10

• Sequence 1: NP_001263137.1
• Gene: chp / 43690
• FlyBaseID: FBgn0267435
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: NP_001073926.1
• Gene: LRRC4B / 94030
• HGNCID: 25042
• Length: 713
• Species: Homo sapiens
• Alignment Length: 334
• Identity: 81/334 - (24%)
• Similarity: 123/334 - (36%)
• Gaps: 113/334 - (33%)

  Fly   478 LDFSENGISSIENDAFHEIGHSLISLKMSHGYSGSALPAEPLRHLTSLQELDFSNNHISSMSDTS 542
            |:..||||..|..|.|                          :||..|:.|..|.|.:..:...:
Human    91 LNLQENGIQVIRTDTF--------------------------KHLRHLEILQLSKNLVRKIEVGA 129

  Fly   543 FHFLKNLRLLELHDNRIEQVLKGTFQGDIHSKLEEISLRFNHLTSISQHTFFDLEALRKLHLDDN 607
            |:.|.:|..|||.|||:..|....|  :..|||.|:.||.|.:.||..:.|..:.:||:|.|.:
Human   130 FNGLPSLNTLELFDNRLTTVPTQAF--EYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGE- 191

  Fly   608 KIDKIERRAFMNLDELEYLSLRGNKINNLADESFQNLPKLEILDMAFNQLPNFNFDYFDQVGTLS 672
                        |..|||:|          :.:|:.|..|..|::....|.:           :.
Human   192 ------------LKRLEYIS----------EAAFEGLVNLRYLNLGMCNLKD-----------IP 223

  Fly   673 NLNVNVSHNQIRQLMYNSSWSGRNEHGGMYHSNIKILDLSHNNISIIHPGYFRPAEISLTHLHLG 737
            ||...|                          .::.|:||.|.:.:|.||.|: ...||..|.|.
Human   224 NLTALV--------------------------RLEELELSGNRLDLIRPGSFQ-GLTSLRKLWLM 261

  Fly   738 YNSLMNTTRDVFGNMPHLQWLDLSYNWIHELDFDAFKNTKQLQLVFFGHNYLSDIPQDIFKPVQG 802
            :..:....|:.|.::..|:.|:||                        ||.|..:|.|:|.|:..
Human   262 HAQVATIERNAFDDLKSLEELNLS------------------------HNNLMSLPHDLFTPLHR 302

  Fly   803 LRIVDFSHN 811
            |..|..:||
Human   303 LERVHLNHN 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chp	NP_001263137.1	LRR	<84..320	CDD:443914
		leucine-rich repeat	84..103	CDD:275380
		leucine-rich repeat	104..128	CDD:275380
		leucine-rich repeat	129..152	CDD:275380
		leucine-rich repeat	153..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		leucine-rich repeat	202..226	CDD:275380
		leucine-rich repeat	227..250	CDD:275380
		leucine-rich repeat	251..279	CDD:275380
		leucine-rich repeat	280..326	CDD:275380
		leucine-rich repeat	327..348	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		PPP1R42	355..564	CDD:455733	24/85 (28%)
		leucine-rich repeat	376..401	CDD:275380
		leucine-rich repeat	426..450	CDD:275378
		leucine-rich repeat	451..474	CDD:275380
		LRR_8	473..559	CDD:404697	22/80 (28%)
		leucine-rich repeat	475..524	CDD:275380	10/45 (22%)
		leucine-rich repeat	500..519	CDD:275380	0/18 (0%)
		leucine-rich repeat	525..548	CDD:275380	6/22 (27%)
		LRR	<540..>834	CDD:443914	67/272 (25%)
		leucine-rich repeat	549..574	CDD:275380	9/24 (38%)
		leucine-rich repeat	575..598	CDD:275380	8/22 (36%)
		leucine-rich repeat	599..622	CDD:275380	5/22 (23%)
		leucine-rich repeat	623..646	CDD:275380	6/22 (27%)
		leucine-rich repeat	647..730	CDD:275380	14/82 (17%)
		leucine-rich repeat	648..673	CDD:275380	2/24 (8%)
		leucine-rich repeat	674..705	CDD:275380	2/30 (7%)
		LRR	<730..1081	CDD:443914	21/82 (26%)
		leucine-rich repeat	731..754	CDD:275380	5/22 (23%)
		leucine-rich repeat	755..778	CDD:275380	4/22 (18%)
		leucine-rich repeat	779..802	CDD:275380	7/22 (32%)
		leucine-rich repeat	803..823	CDD:275380	4/9 (44%)
		leucine-rich repeat	852..876	CDD:275380
		leucine-rich repeat	877..900	CDD:275380
		leucine-rich repeat	901..925	CDD:275380
		leucine-rich repeat	926..946	CDD:275380
		leucine-rich repeat	947..970	CDD:275380
		leucine-rich repeat	971..993	CDD:275380
		leucine-rich repeat	994..1014	CDD:275380
		leucine-rich repeat	1019..1042	CDD:275380
LRRC4B	NP_001073926.1	LRRNT	57..90	CDD:214470
		LRR	<87..>312	CDD:443914	81/334 (24%)
		LRR 1	87..108		8/42 (19%)
		leucine-rich repeat	88..111	CDD:275380	10/45 (22%)
		LRR 2	111..132		5/20 (25%)
		leucine-rich repeat	112..135	CDD:275380	6/22 (27%)
		LRR 3	135..156		9/22 (41%)
		leucine-rich repeat	136..159	CDD:275380	9/24 (38%)
		LRR 4	159..180		9/20 (45%)
		leucine-rich repeat	160..183	CDD:275380	8/22 (36%)
		LRR 5	183..205		10/44 (23%)
		leucine-rich repeat	184..208	CDD:275380	11/46 (24%)
		LRR 6	208..229		5/31 (16%)
		leucine-rich repeat	209..230	CDD:275380	6/57 (11%)
		LRR 7	230..251		8/21 (38%)
		leucine-rich repeat	231..254	CDD:275380	8/23 (35%)
		LRR 8	254..275		6/20 (30%)
		leucine-rich repeat	255..278	CDD:275380	5/22 (23%)
		LRR 9	278..299		10/44 (23%)
		leucine-rich repeat	279..300	CDD:275380	10/44 (23%)
		LRRCT	311..361	CDD:214507	1/1 (100%)
		I-set	364..453	CDD:400151
		Ig strand B	381..385	CDD:409353
		Ig strand C	393..397	CDD:409353
		Ig strand E	419..423	CDD:409353
		Ig strand F	433..438	CDD:409353
		Ig strand G	446..449	CDD:409353
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..551
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	694..713