DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chp and Lrrc15

DIOPT Version :9

Sequence 1:	NP_001263137.1	Gene:	chp / 43690	FlyBaseID:	FBgn0267435	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_083249.1	Gene:	Lrrc15 / 74488	MGIID:	1921738	Length:	579	Species:	Mus musculus

Alignment Length:	427	Identity:	121/427 - (28%)
Similarity:	191/427 - (44%)	Gaps:	83/427 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 ISSIENDAFHEIGHSLISLKMSHGYSGSALPAEPLRHLTSLQELDFSNNHISSMSDTSFHFLKNL 549
            |:.:..|.|..|. :||:|||......:.:|. ..|:|.||:.|..:||.:.::....|..:.||
Mouse    65 ITELPEDKFLNIS-ALIALKMEKNELANIMPG-AFRNLGSLRHLSLANNKLKNLPVRLFQDVNNL 127

  Fly   550 RLLELHDNRIEQVLKGTFQGDIHSKLEEISLRFNHLTSISQHTFFDLEALRKLHLDDNKIDKIER 614
            ..|.|.:|::.|:....|..  .|.|:|:.|..|:|..|.:..|..|..|.||:|.:|....:..
Mouse   128 ETLLLSNNQLVQIQPAQFSQ--FSNLKELQLYGNNLEYIPEGVFDHLVGLTKLNLGNNGFTHLSP 190

  Fly   615 RAFMNLDELEYLSLRGNKINNLADESFQNLPKLEILDMAFNQLPNFNFDYFDQVGTLSNLNVNVS 679
            |.|.:|..|:.|.|..|:::::...:|..|..|:.|.:..|           |:||||
Mouse   191 RVFQHLGNLQVLRLYENRLSDIPMGTFDALGNLQELALQEN-----------QIGTLS------- 237

  Fly   680 HNQIRQLMYNSSWSGRNEHGGMYHS--NIKILDLSHNNISIIHPGYFRPAEISLTHLH---LGYN 739
                               .|::|:  |::.|.||:|:||.:.||.|    :.|.||:   |..|
Mouse   238 -------------------PGLFHNNRNLQRLYLSNNHISHLPPGIF----MQLPHLNKLTLFGN 279

  Fly   740 SLMNTTRDVFGNMPHLQWLDLSYNWIHELDFDAFKNTKQLQLVFFGHNYLS-------------- 790
            ||...:..|||.||:|:.|.|..|.|..|..:||.:..|||::...||.||
Mouse   280 SLKELSPGVFGPMPNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISPGAFNGLTNLR 344

  Fly   791 ----------DIPQDIFKPVQGLRIVDFSHNHLRGLPDNLFYN-GGMEKLDVSHNMMLKIPSSSL 844
                      |:..::|:.:..||.|...:|.||.||.::|.| .|:..:.:.:|.:..:|....
Mouse   345 ELSLHTNALQDLDGNVFRSLANLRNVSLQNNRLRQLPGSIFANVNGLMTIQLQNNNLENLPLGIF 409

  Fly   845 SSLAALTLCELHLSNN------FISTIHSMDLSNKFR 875
            ..|.  .||||.|.:|      .|..:|...:.|:.|
Mouse   410 DHLG--NLCELRLYDNPWRCDSNILPLHDWLILNRAR 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chp	NP_001263137.1	leucine-rich repeat	84..103	CDD:275380
		LRR_8	102..163	CDD:290566
		leucine-rich repeat	104..128	CDD:275380
		LRR_RI	<128..261	CDD:238064
		leucine-rich repeat	129..152	CDD:275380
		LRR_8	152..212	CDD:290566
		leucine-rich repeat	153..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR_8	202..261	CDD:290566
		leucine-rich repeat	202..226	CDD:275380
		leucine-rich repeat	227..250	CDD:275380
		leucine-rich repeat	251..279	CDD:275380
		leucine-rich repeat	280..326	CDD:275380
		LRR_8	326..386	CDD:290566
		leucine-rich repeat	327..348	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		leucine-rich repeat	426..450	CDD:275378
		LRR_RI	<448..651	CDD:238064	49/165 (30%)
		leucine-rich repeat	451..474	CDD:275380
		LRR_8	473..559	CDD:290566	23/73 (32%)
		leucine-rich repeat	475..524	CDD:275380	12/38 (32%)
		leucine-rich repeat	500..519	CDD:275380	6/18 (33%)
		leucine-rich repeat	525..548	CDD:275380	5/22 (23%)
		leucine-rich repeat	549..574	CDD:275380	6/24 (25%)
		LRR_8	573..633	CDD:290566	21/59 (36%)
		leucine-rich repeat	575..598	CDD:275380	8/22 (36%)
		leucine-rich repeat	599..622	CDD:275380	8/22 (36%)
		LRR_8	622..683	CDD:290566	14/60 (23%)
		leucine-rich repeat	623..646	CDD:275380	6/22 (27%)
		leucine-rich repeat	647..730	CDD:275380	20/84 (24%)
		leucine-rich repeat	648..673	CDD:275380	6/24 (25%)
		leucine-rich repeat	674..705	CDD:275380	2/32 (6%)
		LRR_8	704..763	CDD:290566	25/63 (40%)
		leucine-rich repeat	731..754	CDD:275380	11/25 (44%)
		LRR_8	753..813	CDD:290566	22/83 (27%)
		leucine-rich repeat	755..778	CDD:275380	8/22 (36%)
		leucine-rich repeat	779..802	CDD:275380	8/46 (17%)
		leucine-rich repeat	803..823	CDD:275380	9/19 (47%)
		leucine-rich repeat	852..876	CDD:275380	10/30 (33%)
		LRR_8	854..910	CDD:290566	8/28 (29%)
		LRR_RI	<877..>1006	CDD:238064
		leucine-rich repeat	877..900	CDD:275380
		leucine-rich repeat	901..925	CDD:275380
		leucine-rich repeat	926..946	CDD:275380
		LRR_8	947..1004	CDD:290566
		leucine-rich repeat	947..970	CDD:275380
		leucine-rich repeat	971..993	CDD:275380
		LRR_8	992..1049	CDD:290566
		leucine-rich repeat	994..1014	CDD:275380
		leucine-rich repeat	1019..1042	CDD:275380
Lrrc15	NP_083249.1	LRR 1	54..75		3/9 (33%)
		leucine-rich repeat	58..78	CDD:275380	4/13 (31%)
		LRR 2	78..99		6/21 (29%)
		PLN00113	82..>401	CDD:215061	103/362 (28%)
		LRR 3	102..123		6/20 (30%)
		leucine-rich repeat	103..126	CDD:275380	5/22 (23%)
		LRR 4	126..147		7/20 (35%)
		leucine-rich repeat	127..150	CDD:275380	6/24 (25%)
		LRR 5	150..171		7/20 (35%)
		leucine-rich repeat	151..174	CDD:275380	8/22 (36%)
		LRR 6	174..195		7/20 (35%)
		leucine-rich repeat	175..198	CDD:275380	8/22 (36%)
		LRR 7	198..219		5/20 (25%)
		leucine-rich repeat	199..222	CDD:275380	6/22 (27%)
		LRR 8	222..243		9/57 (16%)
		leucine-rich repeat	223..246	CDD:275380	10/59 (17%)
		LRR 9	246..267		10/24 (42%)
		leucine-rich repeat	247..270	CDD:275380	10/26 (38%)
		LRR 10	270..291		8/20 (40%)
		leucine-rich repeat	271..294	CDD:275380	9/22 (41%)
		LRR 11	294..315		8/20 (40%)
		leucine-rich repeat	295..318	CDD:275380	8/22 (36%)
		LRR 12	318..339		7/20 (35%)
		leucine-rich repeat	319..342	CDD:275380	6/22 (27%)
		LRR 13	342..363		2/20 (10%)
		leucine-rich repeat	343..364	CDD:275380	2/20 (10%)
		LRR 14	366..387		9/20 (45%)
		leucine-rich repeat	367..387	CDD:275380	9/19 (47%)
		LRR 15	390..411		3/20 (15%)
		leucine-rich repeat	391..412	CDD:275380	2/20 (10%)
		LRRCT	423..>462	CDD:214507	5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..509
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42484
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910