DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chp and LRRC4

DIOPT Version :9

Sequence 1:	NP_001263137.1	Gene:	chp / 43690	FlyBaseID:	FBgn0267435	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_071426.1	Gene:	LRRC4 / 64101	HGNCID:	15586	Length:	653	Species:	Homo sapiens

Alignment Length:	657	Identity:	140/657 - (21%)
Similarity:	239/657 - (36%)	Gaps:	182/657 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 SSSVGPEDFKDF---GVELEDLQITRASLS----GIQSHAFKHVRGLKRLDFSENGISSIENDAF 493
            ::|.||::....   ..:...:..||..||    ||.|:.       :.|:..||.|..|:.|.|
Human    38 AASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNT-------RYLNLMENNIQMIQADTF 95

  Fly   494 HEIGHSLISLKMSHGYSGSALPAEPLRHLTSLQELDFSNNHISSMSDTSFHFLKNLRLLELHDNR 558
                                      |||..|:.|....|.|..:...:|:.|.:|..|||.||.
Human    96 --------------------------RHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNW 134

  Fly   559 IEQVLKGTFQGDIHSKLEEISLRFNHLTSISQHTFFDLEALRKLHLDD-NKIDKIERRAFMNLDE 622
            :..:..|.|  :..|||.|:.||.|.:.||..:.|..:.:|.:|.|.: .|::.|...||..|..
Human   135 LTVIPSGAF--EYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFN 197

  Fly   623 LEYLSLRGNKINNLADESFQNLPKLEILDMAFNQLPNFNFDYFDQVGTLSNLNVNVSHNQIRQLM 687
            |:||:|....|.::  .:...|..||.|:|:.|..|......|..:.:|..|  .|.::|:
Human   198 LKYLNLGMCNIKDM--PNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKL--WVMNSQV---- 254

  Fly   688 YNSSWSGRNEHGGMYHSNIKILDLSHNNISIIHPGYFRPAEISLTHLHLGYNSLMNTTRDVFGNM 752
               |...||...|:  :::..|:|:|||:|.:....|.|... |..|||.:|. .|...|:.
Human   255 ---SLIERNAFDGL--ASLVELNLAHNNLSSLPHDLFTPLRY-LVELHLHHNP-WNCDCDIL--- 309

  Fly   753 PHLQW-------------------LDLSYNWIHELDFDAFKNTKQLQLVFFGHNYLSDIPQDIFK 798
             .|.|                   :.:...::.|:|..:|:.:..         ::.|.|:|
Human   310 -WLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAP---------FIMDAPRD--- 361

  Fly   799 PVQGLRIVDFSHNHLRGLPDNLFYNGGMEKLDVSHNMM--LKIPSSSLSSLAALTLCELHLSNNF 861
                                          |::|...|  ||..:..:||:..|      |.|..
Human   362 ------------------------------LNISEGRMAELKCRTPPMSSVKWL------LPNGT 390

  Fly   862 ISTIHSMDLSNKFRSLRYL-----DISYNYLLRIDDAVFATMPKLAVLDLSHNRDLKVMDKSFMG 921
            :       ||:..|..|..     .::::::|..|..|:..|    |.:::.|.:....
Human   391 V-------LSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCM----VTNVAGNSNASAY------ 438

  Fly   922 LENSLIKLGLENISLSTVPEIRLKYL--REFRLGYNELP--SIPQELAHNMSNLRMLDLSNNDLT 982
            |..|..:|...|.|..|...:....:  .:....|..:|  |...:.|:..|            |
Human   439 LNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTS------------T 491

  Fly   983 NVPLMTQALPHLRRLMLSGNPITSLNNNSFDGVNEDLEMLDISNFRLHYFEYGCLDSLPHLRSLK 1047
            .|.:.|..:|  :::.:.....|.....|.|.|.:..:::           .||..::..|.:..
Human   492 TVLIQTTRVP--KQVAVPATDTTDKMQTSLDEVMKTTKII-----------IGCFVAVTLLAAAM 543

  Fly  1048 LTAYSHL 1054
            |..:..|
Human   544 LIVFYKL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chp	NP_001263137.1	leucine-rich repeat	84..103	CDD:275380
		LRR_8	102..163	CDD:290566
		leucine-rich repeat	104..128	CDD:275380
		LRR_RI	<128..261	CDD:238064
		leucine-rich repeat	129..152	CDD:275380
		LRR_8	152..212	CDD:290566
		leucine-rich repeat	153..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR_8	202..261	CDD:290566
		leucine-rich repeat	202..226	CDD:275380
		leucine-rich repeat	227..250	CDD:275380
		leucine-rich repeat	251..279	CDD:275380
		leucine-rich repeat	280..326	CDD:275380
		LRR_8	326..386	CDD:290566
		leucine-rich repeat	327..348	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		leucine-rich repeat	426..450	CDD:275378	3/16 (19%)
		LRR_RI	<448..651	CDD:238064	57/207 (28%)
		leucine-rich repeat	451..474	CDD:275380	7/26 (27%)
		LRR_8	473..559	CDD:290566	22/85 (26%)
		leucine-rich repeat	475..524	CDD:275380	10/48 (21%)
		leucine-rich repeat	500..519	CDD:275380	0/18 (0%)
		leucine-rich repeat	525..548	CDD:275380	6/22 (27%)
		leucine-rich repeat	549..574	CDD:275380	8/24 (33%)
		LRR_8	573..633	CDD:290566	22/60 (37%)
		leucine-rich repeat	575..598	CDD:275380	8/22 (36%)
		leucine-rich repeat	599..622	CDD:275380	8/23 (35%)
		LRR_8	622..683	CDD:290566	16/60 (27%)
		leucine-rich repeat	623..646	CDD:275380	6/22 (27%)
		leucine-rich repeat	647..730	CDD:275380	23/82 (28%)
		leucine-rich repeat	648..673	CDD:275380	7/24 (29%)
		leucine-rich repeat	674..705	CDD:275380	7/30 (23%)
		LRR_8	704..763	CDD:290566	17/77 (22%)
		leucine-rich repeat	731..754	CDD:275380	7/22 (32%)
		LRR_8	753..813	CDD:290566	8/78 (10%)
		leucine-rich repeat	755..778	CDD:275380	5/41 (12%)
		leucine-rich repeat	779..802	CDD:275380	3/22 (14%)
		leucine-rich repeat	803..823	CDD:275380	0/19 (0%)
		leucine-rich repeat	852..876	CDD:275380	4/23 (17%)
		LRR_8	854..910	CDD:290566	11/60 (18%)
		LRR_RI	<877..>1006	CDD:238064	22/137 (16%)
		leucine-rich repeat	877..900	CDD:275380	5/27 (19%)
		leucine-rich repeat	901..925	CDD:275380	3/23 (13%)
		leucine-rich repeat	926..946	CDD:275380	4/19 (21%)
		LRR_8	947..1004	CDD:290566	9/60 (15%)
		leucine-rich repeat	947..970	CDD:275380	4/26 (15%)
		leucine-rich repeat	971..993	CDD:275380	3/21 (14%)
		LRR_8	992..1049	CDD:290566	8/56 (14%)
		leucine-rich repeat	994..1014	CDD:275380	2/19 (11%)
		leucine-rich repeat	1019..1042	CDD:275380	2/22 (9%)
LRRC4	NP_071426.1	LRRNT	46..79	CDD:214470	7/39 (18%)
		LRR	<74..291	CDD:227223	72/264 (27%)
		LRR 1	76..97		7/53 (13%)
		leucine-rich repeat	77..100	CDD:275380	10/55 (18%)
		LRR 2	100..121		5/20 (25%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR 3	124..145		8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	8/24 (33%)
		LRR 4	148..169		9/20 (45%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		LRR 5	172..194		7/21 (33%)
		leucine-rich repeat	173..197	CDD:275380	8/23 (35%)
		LRR 6	197..218		5/22 (23%)
		leucine-rich repeat	198..219	CDD:275380	6/22 (27%)
		LRR 7	219..240		7/20 (35%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		LRR 8	243..264		7/29 (24%)
		leucine-rich repeat	244..267	CDD:275380	8/33 (24%)
		LRR 9	267..288		7/20 (35%)
		leucine-rich repeat	268..289	CDD:275380	7/20 (35%)
		LRRCT	300..351	CDD:214507	8/55 (15%)
		IG	359..441	CDD:214652	23/137 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24369
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010