DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment chp and igfals

DIOPT Version :9

Sequence 1:NP_001263137.1 Gene:chp / 43690 FlyBaseID:FBgn0267435 Length:1338 Species:Drosophila melanogaster
Sequence 2:XP_003198203.1 Gene:igfals / 570758 ZFINID:ZDB-GENE-061009-25 Length:614 Species:Danio rerio


Alignment Length:593 Identity:147/593 - (24%)
Similarity:244/593 - (41%) Gaps:110/593 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 YRLKI----SGNHLTEIPDDAFTGLERSLWELILPQNDLVEIPSKSLRHLQKLRHLDLGYNHITH 165
            |.|::    |..:.|::|.|.... .||||   |..|....:|:.:...|..|..|:|..:.:..
Zfish    60 YSLELNVYCSTRNFTQVPSDIPLS-TRSLW---LDGNLFSNLPAGAFEKLTNLEFLNLQSSLLVS 120

  Fly   166 IQHDSFRGLEDSLQTLILRENCISQLMSHSFSGLLILETLDLSGNNLFEIDPNVFVDGMPRLTRL 230
            :...:|||| :||..|.|..|.:..|....|.|...|.||.|:.|.:|.||..:|. ||..:..|
Zfish   121 LDAHAFRGL-NSLAHLHLERNNLRSLSGLVFQGTSNLATLSLNNNQMFRIDDRLFA-GMSHMWLL 183

  Fly   231 LLTDNILSEIPYDALGPLKSLRTLDISHNVIWSLSGNETYEIKASTKLNLDNLHLEYNHIEVLPP 295
            .|..|:||.:|......|..||.|        .|:||                .|.|     |.|
Zfish   184 NLGWNLLSVLPETGFQDLHGLREL--------ILAGN----------------RLAY-----LQP 219

  Fly   296 NSFKYFDTVNRTFFDGNPIHTLREDAF-KPARIREIYMRYCGLTNISPVAFDSLVNSLQILDLSG 359
            ..|:..:.:......||.:..::.:.| |..:::::|:....:..::|.||..: .||:.||||.
Zfish   220 QLFQGLNELKELDLTGNYLKVIKANVFLKLPKLQKLYLGQNQIVTVAPRAFVGM-KSLRWLDLSR 283

  Fly   360 NNLTKLHHKLFNNFDVLRVISMRDNKIKIQKPTETFNAVHYTLLKLDLSGDRNDPTNLQTLRKMR 424
            |.||.||.:.|.....|.|:.:.:|.|...:| .||..:.|                        
Zfish   284 NRLTVLHDETFIGLQSLHVLRLSNNSINSLRP-GTFRDLQY------------------------ 323

  Fly   425 NMRSLSISRLGSSSVGPEDFKDFGVELEDLQITRASLSGIQSHAFKHVRGLKRLDFSENGISSIE 489
                                      ||:|.:....:..:....|:.:..|:.|:...|.:....
Zfish   324 --------------------------LEELCLYHNQIRALGVRVFEGLGHLEVLNLENNRLQEAR 362

  Fly   490 NDAFHEIGHSLISLKMSHGYSGSALPAEPLRHLTSLQELDFSNNHISSMSDTSFHFLKNLRLLEL 554
            ...|..:.| |..:|:: |....:||.:..:.|:.|..:....:.::.:|..||..|..||.|.|
Zfish   363 MGTFMGLNH-LAVMKLT-GSCFHSLPDQVFKGLSKLHSIHLDRSCLTKVSSQSFSGLTGLRRLFL 425

  Fly   555 HDNRIEQVLKGTFQGDIHSKLEEISLRFNHLTSISQHTFFDLEALRKLHLDDNKIDKIERRAFMN 619
            ..|.|..|.:.:|..  ..:|:::.||||.||:|:.:||:.|:.|..|.|..|.:..:...|.:.
Zfish   426 QHNNISLVERQSFVE--LQRLQQLDLRFNKLTTITSNTFYGLKNLDYLLLSGNLLHNLPAEALLP 488

  Fly   620 LDELEYLSLRGNKINNLADESFQNLPKLEILDMAFNQLPNFNFDYFDQVGTLSNLNVNVSHNQIR 684
            |..|.:|.|.|||:..:.:.:...||:|..|::..|              .|.||.|::..:..:
Zfish   489 LQHLSWLDLSGNKLELILNATIYMLPRLRYLNLKDN--------------ILVNLPVSIPESLDQ 539

  Fly   685 QLMYNSSW 692
            ..:..::|
Zfish   540 LWLSGNNW 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chpNP_001263137.1 leucine-rich repeat 84..103 CDD:275380
LRR_8 102..163 CDD:290566 17/61 (28%)
leucine-rich repeat 104..128 CDD:275380 6/26 (23%)
LRR_RI <128..261 CDD:238064 43/132 (33%)
leucine-rich repeat 129..152 CDD:275380 6/22 (27%)
LRR_8 152..212 CDD:290566 20/59 (34%)
leucine-rich repeat 153..177 CDD:275380 7/23 (30%)
leucine-rich repeat 178..201 CDD:275380 7/22 (32%)
LRR_8 202..261 CDD:290566 21/58 (36%)
leucine-rich repeat 202..226 CDD:275380 11/23 (48%)
leucine-rich repeat 227..250 CDD:275380 7/22 (32%)
leucine-rich repeat 251..279 CDD:275380 6/27 (22%)
leucine-rich repeat 280..326 CDD:275380 9/46 (20%)
LRR_8 326..386 CDD:290566 19/59 (32%)
leucine-rich repeat 327..348 CDD:275380 4/20 (20%)
leucine-rich repeat 352..375 CDD:275380 11/22 (50%)
leucine-rich repeat 376..401 CDD:275380 7/24 (29%)
leucine-rich repeat 426..450 CDD:275378 0/23 (0%)
LRR_RI <448..651 CDD:238064 54/202 (27%)
leucine-rich repeat 451..474 CDD:275380 4/22 (18%)
LRR_8 473..559 CDD:290566 21/85 (25%)
leucine-rich repeat 475..524 CDD:275380 11/48 (23%)
leucine-rich repeat 500..519 CDD:275380 5/18 (28%)
leucine-rich repeat 525..548 CDD:275380 5/22 (23%)
leucine-rich repeat 549..574 CDD:275380 8/24 (33%)
LRR_8 573..633 CDD:290566 22/59 (37%)
leucine-rich repeat 575..598 CDD:275380 11/22 (50%)
leucine-rich repeat 599..622 CDD:275380 6/22 (27%)
LRR_8 622..683 CDD:290566 15/60 (25%)
leucine-rich repeat 623..646 CDD:275380 7/22 (32%)
leucine-rich repeat 647..730 CDD:275380 8/46 (17%)
leucine-rich repeat 648..673 CDD:275380 3/24 (13%)
leucine-rich repeat 674..705 CDD:275380 3/19 (16%)
LRR_8 704..763 CDD:290566
leucine-rich repeat 731..754 CDD:275380
LRR_8 753..813 CDD:290566
leucine-rich repeat 755..778 CDD:275380
leucine-rich repeat 779..802 CDD:275380
leucine-rich repeat 803..823 CDD:275380
leucine-rich repeat 852..876 CDD:275380
LRR_8 854..910 CDD:290566
LRR_RI <877..>1006 CDD:238064
leucine-rich repeat 877..900 CDD:275380
leucine-rich repeat 901..925 CDD:275380
leucine-rich repeat 926..946 CDD:275380
LRR_8 947..1004 CDD:290566
leucine-rich repeat 947..970 CDD:275380
leucine-rich repeat 971..993 CDD:275380
LRR_8 992..1049 CDD:290566
leucine-rich repeat 994..1014 CDD:275380
leucine-rich repeat 1019..1042 CDD:275380
igfalsXP_003198203.1 LRRNT 48..81 CDD:279764 6/20 (30%)
leucine-rich repeat 65..83 CDD:275380 4/17 (24%)
leucine-rich repeat 84..107 CDD:275380 8/25 (32%)
LRR_8 85..142 CDD:290566 20/60 (33%)
leucine-rich repeat 108..131 CDD:275380 7/23 (30%)
LRR_8 131..214 CDD:290566 32/107 (30%)
leucine-rich repeat 132..155 CDD:275380 7/22 (32%)
leucine-rich repeat 156..203 CDD:275380 18/47 (38%)
leucine-rich repeat 204..227 CDD:275380 11/51 (22%)
LRR_RI <219..456 CDD:238064 64/292 (22%)
LRR_8 227..286 CDD:290566 15/59 (25%)
leucine-rich repeat 228..251 CDD:275380 4/22 (18%)
leucine-rich repeat 252..275 CDD:275380 4/23 (17%)
LRR_8 274..334 CDD:290566 23/110 (21%)
leucine-rich repeat 276..299 CDD:275380 11/22 (50%)
leucine-rich repeat 300..323 CDD:275380 7/23 (30%)
leucine-rich repeat 324..347 CDD:275380 4/22 (18%)
leucine-rich repeat 348..369 CDD:275380 4/20 (20%)
LRR_8 371..430 CDD:290566 17/60 (28%)
leucine-rich repeat 396..419 CDD:275380 5/22 (23%)
LRR_8 418..478 CDD:290566 23/61 (38%)
leucine-rich repeat 420..443 CDD:275380 8/24 (33%)
leucine-rich repeat 444..467 CDD:275380 11/22 (50%)
LRR_8 466..524 CDD:290566 16/57 (28%)
leucine-rich repeat 468..486 CDD:275380 4/17 (24%)
leucine-rich repeat 492..515 CDD:275380 7/22 (32%)
leucine-rich repeat 516..540 CDD:275380 7/37 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D299282at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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