DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment chp and lrrc4ba

DIOPT Version :9

Sequence 1:NP_001263137.1 Gene:chp / 43690 FlyBaseID:FBgn0267435 Length:1338 Species:Drosophila melanogaster
Sequence 2:XP_021329717.1 Gene:lrrc4ba / 556747 ZFINID:ZDB-GENE-080327-25 Length:729 Species:Danio rerio


Alignment Length:703 Identity:140/703 - (19%)
Similarity:235/703 - (33%) Gaps:248/703 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   478 LDFSENGISSIENDAFHEIGHSLISLKMSHGYSGSALPAEPLRHLTSLQELDFSNNHISSMSDTS 542
            |:..||.|..|::|.|                          :||..|:.|..|.|.|..:...:
Zfish    74 LNLQENTIQVIKSDTF--------------------------KHLRHLEILQLSKNQIRQIEVGA 112

  Fly   543 FHFLKNLRLLELHDNRIEQVLKGTFQGDIHSKLEEISLRFNHLTSISQHTFFDLEALRKLHLDD- 606
            |:.|.||..|||.|||:..|....|  :..|||.|:.||.|.:.::..:.|..:.:||:|.|.: 
Zfish   113 FNGLPNLNTLELFDNRLTLVPSQAF--EYLSKLRELWLRNNPIETLPGYAFHRVPSLRRLDLGEL 175

  Fly   607 NKIDKIERRAFMNLDELEYLSLRGNKINNLADESFQNLPKLEILDMAFNQLPNFNFDYFDQVGTL 671
            .|:|.|...||:.|..|.||        ||.....:::|.|..|                     
Zfish   176 KKLDYISDAAFVGLINLRYL--------NLGMCGLKDIPNLTPL--------------------- 211

  Fly   672 SNLNVNVSHNQIRQLMYNSSWSGRNEHGGMYHSNIKILDLSHNNISIIHPGYFRPAEISLTHLHL 736
                       :|                     ::.|:||.|.:.||.||.|:..| ||..|.|
Zfish   212 -----------VR---------------------LEELELSGNRLEIIRPGSFQGLE-SLRKLWL 243

  Fly   737 GYNSLMNTTRDVFGNMPHLQWLDLSYNWIHELDFDAFKNTKQLQLVFFGHN-------------- 787
            .::.:....|:.|.::.:|:.|:||:|.:|.|..|.|...::|:.|...||              
Zfish   244 MHSQMSVIERNAFDDLKNLEELNLSHNSLHSLPHDLFTPLQKLERVHLNHNPWVCNCDVLWLSWW 308

  Fly   788 ------------------------YLSDIPQD--------IFKPVQGLRIVDFSHNHLRG----- 815
                                    |:.::.|.        |.:|...|.:.:.....|:.     
Zfish   309 LKETVPSNTTCCARCHAPPYLKGKYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTS 373

  Fly   816 -------LPDNLFYNGGMEKLDVS--HNMMLKIPSSSLSSLAALTLCELHLSNNFISTIHSMDLS 871
                   .|:......|..::.:|  |:..|...:.:|......|....:.:.|..:|       
Zfish   374 MTSVNWITPNGTLMTHGSYRVRISVLHDGTLNFTNVTLRDTGQYTCMVTNSAGNTTAT------- 431

  Fly   872 NKFRSLRYLDISYNYLLRIDDAVFATMPKLAVLDLSHNRD--LKVMDKSFMGL------------ 922
             ...::...|:|.||       .:.|...:..::.:...|  |:..:::|:.:            
Zfish   432 -AVLNVTAADVSVNY-------TYFTTVTVETVETTGEEDSALRTFNETFIHIPGPTPSGHLWHE 488

  Fly   923 -----ENSLIKLGLENISLSTVPEIRLKYLREFRLGYNELPSIPQELAHNMSNLRML-------- 974
                 .:||...|..:...:|.|        .|.:..:| ||.|..|...|...:::        
Zfish   489 VVPTTASSLSIFGSSSSPRATKP--------TFTVPISE-PSYPSGLDDVMKTTKIIIGCFVAIT 544

  Fly   975 -----------------DLSNN-------DLTNVPLMTQALPHLRRLMLSGNPITSLNNNSFDGV 1015
                             .|..:       ::.||.....|...||...:||........:...| 
Zfish   545 FMAAVMLVVFYKLRKQHQLHKHHGPARAIEIINVEDEIGAGTGLRGSGISGGSTVPQIGSGGGG- 608

  Fly  1016 NEDLEMLDISNFRLHYFEYGCLDSLPHLRSLKLTAYSHLEHFNIPHLLRHHYN 1068
                     .:.|||:.|   :.:||:     |....||.|:..|    ||:|
Zfish   609 ---------QSLRLHHPE---IVNLPN-----LARADHLNHYYKP----HHFN 640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chpNP_001263137.1 leucine-rich repeat 84..103 CDD:275380
LRR_8 102..163 CDD:290566
leucine-rich repeat 104..128 CDD:275380
LRR_RI <128..261 CDD:238064
leucine-rich repeat 129..152 CDD:275380
LRR_8 152..212 CDD:290566
leucine-rich repeat 153..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380
LRR_8 202..261 CDD:290566
leucine-rich repeat 202..226 CDD:275380
leucine-rich repeat 227..250 CDD:275380
leucine-rich repeat 251..279 CDD:275380
leucine-rich repeat 280..326 CDD:275380
LRR_8 326..386 CDD:290566
leucine-rich repeat 327..348 CDD:275380
leucine-rich repeat 352..375 CDD:275380
leucine-rich repeat 376..401 CDD:275380
leucine-rich repeat 426..450 CDD:275378
LRR_RI <448..651 CDD:238064 51/173 (29%)
leucine-rich repeat 451..474 CDD:275380
LRR_8 473..559 CDD:290566 23/80 (29%)
leucine-rich repeat 475..524 CDD:275380 9/45 (20%)
leucine-rich repeat 500..519 CDD:275380 0/18 (0%)
leucine-rich repeat 525..548 CDD:275380 7/22 (32%)
leucine-rich repeat 549..574 CDD:275380 9/24 (38%)
LRR_8 573..633 CDD:290566 21/60 (35%)
leucine-rich repeat 575..598 CDD:275380 6/22 (27%)
leucine-rich repeat 599..622 CDD:275380 10/23 (43%)
LRR_8 622..683 CDD:290566 8/60 (13%)
leucine-rich repeat 623..646 CDD:275380 5/22 (23%)
leucine-rich repeat 647..730 CDD:275380 13/82 (16%)
leucine-rich repeat 648..673 CDD:275380 1/24 (4%)
leucine-rich repeat 674..705 CDD:275380 1/30 (3%)
LRR_8 704..763 CDD:290566 20/58 (34%)
leucine-rich repeat 731..754 CDD:275380 5/22 (23%)
LRR_8 753..813 CDD:290566 18/105 (17%)
leucine-rich repeat 755..778 CDD:275380 9/22 (41%)
leucine-rich repeat 779..802 CDD:275380 8/68 (12%)
leucine-rich repeat 803..823 CDD:275380 3/31 (10%)
leucine-rich repeat 852..876 CDD:275380 2/23 (9%)
LRR_8 854..910 CDD:290566 7/55 (13%)
LRR_RI <877..>1006 CDD:238064 28/179 (16%)
leucine-rich repeat 877..900 CDD:275380 5/22 (23%)
leucine-rich repeat 901..925 CDD:275380 3/42 (7%)
leucine-rich repeat 926..946 CDD:275380 4/19 (21%)
LRR_8 947..1004 CDD:290566 15/88 (17%)
leucine-rich repeat 947..970 CDD:275380 7/22 (32%)
leucine-rich repeat 971..993 CDD:275380 4/53 (8%)
LRR_8 992..1049 CDD:290566 11/56 (20%)
leucine-rich repeat 994..1014 CDD:275380 4/19 (21%)
leucine-rich repeat 1019..1042 CDD:275380 5/22 (23%)
lrrc4baXP_021329717.1 LRR <60..280 CDD:227223 77/295 (26%)
leucine-rich repeat 71..94 CDD:275380 9/45 (20%)
leucine-rich repeat 95..118 CDD:275380 7/22 (32%)
leucine-rich repeat 119..142 CDD:275380 9/24 (38%)
leucine-rich repeat 143..166 CDD:275380 6/22 (27%)
leucine-rich repeat 167..191 CDD:275380 10/23 (43%)
leucine-rich repeat 192..213 CDD:275380 8/60 (13%)
leucine-rich repeat 214..237 CDD:275380 10/23 (43%)
leucine-rich repeat 238..261 CDD:275380 5/22 (23%)
leucine-rich repeat 262..283 CDD:275380 9/20 (45%)
TPKR_C2 294..344 CDD:326558 3/49 (6%)
I-set 347..436 CDD:333254 13/96 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24369
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
33.010

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