DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chp and scrib

DIOPT Version :9

Sequence 1:	NP_001263137.1	Gene:	chp / 43690	FlyBaseID:	FBgn0267435	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster

Alignment Length:	598	Identity:	152/598 - (25%)
Similarity:	244/598 - (40%)	Gaps:	121/598 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 PEDFKDFGVELEDLQITRASLSGIQSHAFKHVRGLKRLDFSENGISSIENDAFHEIGHSLISLKM 505
            ||:...:...||:|.:....:..:..:.|: :..|::|..|:|.|..:..|.  :...:|:.|.:
  Fly    29 PEEILRYSRTLEELFLDANHIRDLPKNFFR-LHRLRKLGLSDNEIGRLPPDI--QNFENLVELDV 90

  Fly   506 SHGYSGSALPAEP--LRHLTSLQELDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLKGTFQ 568
            |.    :.:|..|  ::||.|||..|||:|.|..: .:.|..||||.:|.|:|..:.     |..
  Fly    91 SR----NDIPDIPDDIKHLQSLQVADFSSNPIPKL-PSGFSQLKNLTVLGLNDMSLT-----TLP 145

  Fly   569 GDIHS--KLEEISLRFNHLTSISQHTFFDLEALRKLHLDDNKIDKIERRAFMNLDELEYLSLRGN 631
            .|..|  :||.:.||.|.|..:.: |...|..|::|.|.||:|:          |...||..
  Fly   146 ADFGSLTQLESLELRENLLKHLPE-TISQLTKLKRLDLGDNEIE----------DLPPYLGY--- 196

  Fly   632 KINNLADESFQNLPKLEILDMAFNQLPNFNFDYFDQVGTLSNLN-VNVSHNQIRQLMYNSSWSGR 695
                        ||.|..|.:..|||....    .::|.|:.|. ::||.|::.:|        .
  Fly   197 ------------LPGLHELWLDHNQLQRLP----PELGLLTKLTYLDVSENRLEEL--------P 237

  Fly   696 NEHGGMYHSNIKILDLSHNNISIIHPGYFRPAEIS-LTHLHLGYNSLMNTTRDVFGNMPHLQWLD 759
            ||..|:.  ::..|||:.|.:..:..|.   |::| ||.|.|..|.|.. ..|..||..::|.|.
  Fly   238 NEISGLV--SLTDLDLAQNLLEALPDGI---AKLSRLTILKLDQNRLQR-LNDTLGNCENMQELI 296

  Fly   760 LSYNWIHELDFDAFKNTKQLQLVFFGHNYLSDIPQDIFKPVQGLRIVDFSHNHLRGLPDNLFYNG 824
            |:.|::.||.....:.|| |..:....|.|..:|.:|.: ...|.::....|.|:.||..|....
  Fly   297 LTENFLSELPASIGQMTK-LNNLNVDRNALEYLPLEIGQ-CANLGVLSLRDNKLKKLPPELGNCT 359

  Fly   825 GMEKLDVSHNMMLKIPSSSLSSLAALTLCELHLSNNFISTIHSMDLSNKFRSLRYLDISYNYLLR 889
            .:..||||.|.:|.:|    .||..|.|..:.||.|              :|...|....:....
  Fly   360 VLHVLDVSGNQLLYLP----YSLVNLQLKAVWLSEN--------------QSQPLLTFQPDTDAE 406

  Fly   890 IDDAVFA--TMPKLAVLDLSHNRDLKVMDKSFMGLENS--LIKLGLENISLSTVPEIR------- 943
            ..:.|.:  .:|:.....::..|||:...:.|...|.|  ::|...|.......|.:|
  Fly   407 TGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSRTVVKFSEEATQEKETPFVRQNTPHPK 471

  Fly   944 --------LKYLREFRLGYNELPSIPQE----LAHNMSNLRMLDLSNNDLTNVPLMTQALPHLRR 996
                    ||..|.....:..|.::|:|    ||...:..|  .::||.        |..||..:
  Fly   472 DLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAETPTETR--TIANNH--------QQQPHPVQ 526

  Fly   997 LMLSGNPITSLNN 1009
                 .||..:|:
  Fly   527 -----QPIVGVNS 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chp	NP_001263137.1	leucine-rich repeat	84..103	CDD:275380
		LRR_8	102..163	CDD:290566
		leucine-rich repeat	104..128	CDD:275380
		LRR_RI	<128..261	CDD:238064
		leucine-rich repeat	129..152	CDD:275380
		LRR_8	152..212	CDD:290566
		leucine-rich repeat	153..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR_8	202..261	CDD:290566
		leucine-rich repeat	202..226	CDD:275380
		leucine-rich repeat	227..250	CDD:275380
		leucine-rich repeat	251..279	CDD:275380
		leucine-rich repeat	280..326	CDD:275380
		LRR_8	326..386	CDD:290566
		leucine-rich repeat	327..348	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		leucine-rich repeat	426..450	CDD:275378	2/8 (25%)
		LRR_RI	<448..651	CDD:238064	56/206 (27%)
		leucine-rich repeat	451..474	CDD:275380	4/22 (18%)
		LRR_8	473..559	CDD:290566	29/87 (33%)
		leucine-rich repeat	475..524	CDD:275380	13/50 (26%)
		leucine-rich repeat	500..519	CDD:275380	5/20 (25%)
		leucine-rich repeat	525..548	CDD:275380	9/22 (41%)
		leucine-rich repeat	549..574	CDD:275380	7/26 (27%)
		LRR_8	573..633	CDD:290566	18/61 (30%)
		leucine-rich repeat	575..598	CDD:275380	8/22 (36%)
		leucine-rich repeat	599..622	CDD:275380	6/22 (27%)
		LRR_8	622..683	CDD:290566	15/61 (25%)
		leucine-rich repeat	623..646	CDD:275380	3/22 (14%)
		leucine-rich repeat	647..730	CDD:275380	21/83 (25%)
		leucine-rich repeat	648..673	CDD:275380	6/24 (25%)
		leucine-rich repeat	674..705	CDD:275380	8/31 (26%)
		LRR_8	704..763	CDD:290566	19/59 (32%)
		leucine-rich repeat	731..754	CDD:275380	9/22 (41%)
		LRR_8	753..813	CDD:290566	15/59 (25%)
		leucine-rich repeat	755..778	CDD:275380	7/22 (32%)
		leucine-rich repeat	779..802	CDD:275380	5/22 (23%)
		leucine-rich repeat	803..823	CDD:275380	6/19 (32%)
		leucine-rich repeat	852..876	CDD:275380	4/23 (17%)
		LRR_8	854..910	CDD:290566	7/57 (12%)
		LRR_RI	<877..>1006	CDD:238064	29/151 (19%)
		leucine-rich repeat	877..900	CDD:275380	2/24 (8%)
		leucine-rich repeat	901..925	CDD:275380	5/23 (22%)
		leucine-rich repeat	926..946	CDD:275380	5/34 (15%)
		LRR_8	947..1004	CDD:290566	12/60 (20%)
		leucine-rich repeat	947..970	CDD:275380	6/26 (23%)
		leucine-rich repeat	971..993	CDD:275380	4/21 (19%)
		LRR_8	992..1049	CDD:290566	5/18 (28%)
		leucine-rich repeat	994..1014	CDD:275380	3/16 (19%)
		leucine-rich repeat	1019..1042	CDD:275380
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	85/310 (27%)
		leucine-rich repeat	18..38	CDD:275380	2/8 (25%)
		LRR_8	37..95	CDD:290566	13/64 (20%)
		leucine-rich repeat	39..61	CDD:275380	4/22 (18%)
		leucine-rich repeat	62..84	CDD:275380	6/23 (26%)
		LRR_8	84..138	CDD:290566	22/58 (38%)
		leucine-rich repeat	85..107	CDD:275380	7/25 (28%)
		leucine-rich repeat	108..130	CDD:275380	9/22 (41%)
		LRR_8	129..187	CDD:290566	22/63 (35%)
		leucine-rich repeat	131..153	CDD:275380	7/26 (27%)
		leucine-rich repeat	154..176	CDD:275380	8/22 (36%)
		leucine-rich repeat	177..199	CDD:275380	10/46 (22%)
		LRR_8	198..256	CDD:290566	20/71 (28%)
		leucine-rich repeat	200..222	CDD:275380	7/25 (28%)
		leucine-rich repeat	223..245	CDD:275380	8/31 (26%)
		LRR_8	267..325	CDD:290566	20/59 (34%)
		leucine-rich repeat	269..289	CDD:275380	8/20 (40%)
		leucine-rich repeat	292..314	CDD:275380	6/21 (29%)
		leucine-rich repeat	315..337	CDD:275380	5/22 (23%)
		LRR_4	337..375	CDD:289563	12/37 (32%)
		leucine-rich repeat	361..382	CDD:275380	9/24 (38%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910