DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment chp and IGFALS

DIOPT Version :9

Sequence 1:NP_001263137.1 Gene:chp / 43690 FlyBaseID:FBgn0267435 Length:1338 Species:Drosophila melanogaster
Sequence 2:NP_001139478.1 Gene:IGFALS / 3483 HGNCID:5468 Length:643 Species:Homo sapiens


Alignment Length:675 Identity:155/675 - (22%)
Similarity:245/675 - (36%) Gaps:201/675 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   334 YCGLTNISPVAFDSLVNSLQILDLSGNNLTKLHHKLFNNFDVLRVISMRDNKIKIQKPTETFNAV 398
            :|...|::.:. |.:....|.|.|.||||:.:....|.|...|..::::..::...:|       
Human    97 FCSSRNLTRLP-DGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEP------- 153

  Fly   399 HYTLLKLDLSGDRNDPTNLQTLRKMRN-MRSLSISRLGSSSVGPEDFKDFGVELEDLQITRASLS 462
             ..||.|:         ||..|...|| :|||::.                              
Human   154 -QALLGLE---------NLCHLHLERNQLRSLALG------------------------------ 178

  Fly   463 GIQSHAFKHVRGLKRLDFSENGISSIENDAFHEIGHSLISLKMSHGYSGSALPAEPLRHLTSLQE 527
                 .|.|...|..|..|.|.:|.:|:..|..:|                          ||.:
Human   179 -----TFAHTPALASLGLSNNRLSRLEDGLFEGLG--------------------------SLWD 212

  Fly   528 LDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLKGTFQGDIHSKLEEISLRFNHLTSISQHT 592
            |:...|.::.:.|.:|..|.:||.|.|..||:..:....|.|  .::|.|:.|..|.|.:|..:.
Human   213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSG--LAELRELDLSRNALRAIKANV 275

  Fly   593 FFDLEALRKLHLDDNKIDKIERRAFMNLDELEYLSLRGNKINNLADESFQNLPKLEILDMAFNQL 657
            |..|..|:||:||.|.|..:...||:.|..|.:|.|..|::..|.:::|..|             
Human   276 FVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL------------- 327

  Fly   658 PNFNFDYFDQVGTLSNLNVNVSHNQIRQLMYNSSWSGRNEHGGMYHSNIKILDLSHNNISIIHPG 722
                                                          ..:::|.||||.|:.:.|.
Human   328 ----------------------------------------------LGLRVLRLSHNAIASLRPR 346

  Fly   723 YFRPAEISLTHLHLGYNSLMNTTRDVFGNMPHLQWLDLSYNWIHELDFDAFKNTKQLQLVFFGHN 787
            .|:       .||.                  |:.|.|.:|.|.:|...:|:...||:::...||
Human   347 TFK-------DLHF------------------LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHN 386

  Fly   788 YLSDIPQDIFKPVQGLRIVDFSHNHLRGLPDNLFYN-GGMEKLDVSHNMMLKIPSSSLSSLAALT 851
            .|.::....|..:..:.:::.|.|.||.||:.:|.. |.:..|.:..:.:.:|...:.:.|:.|.
Human   387 QLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLR 451

  Fly   852 LCELHLSNNFISTIHSMDLSNKFRSLRYLDISYNYLLRIDDAVFATMPKLAVLDLSHNRDLKVMD 916
              .|.|.:|.:..|....|.. ...|..||::.|.|..:...:|..:.||..|.||.||      
Human   452 --RLFLKDNGLVGIEEQSLWG-LAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR------ 507

  Fly   917 KSFMGLENSLIKLGLENISLSTVPEIRLKYL-REFRL--GYNELPSIPQELAHNMSNLRMLDLSN 978
                               |:.:|...|..| |.|.|  .:|.|.::|..|...:..||.|.|.|
Human   508 -------------------LAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRN 553

  Fly   979 NDLTNVPLMTQALPHLRRLMLSGNP 1003
            |.|..   .|...|.|.||.|.|||
Human   554 NSLRT---FTPQPPGLERLWLEGNP 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chpNP_001263137.1 leucine-rich repeat 84..103 CDD:275380
LRR_8 102..163 CDD:290566
leucine-rich repeat 104..128 CDD:275380
LRR_RI <128..261 CDD:238064
leucine-rich repeat 129..152 CDD:275380
LRR_8 152..212 CDD:290566
leucine-rich repeat 153..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380
LRR_8 202..261 CDD:290566
leucine-rich repeat 202..226 CDD:275380
leucine-rich repeat 227..250 CDD:275380
leucine-rich repeat 251..279 CDD:275380
leucine-rich repeat 280..326 CDD:275380
LRR_8 326..386 CDD:290566 13/51 (25%)
leucine-rich repeat 327..348 CDD:275380 3/13 (23%)
leucine-rich repeat 352..375 CDD:275380 9/22 (41%)
leucine-rich repeat 376..401 CDD:275380 2/24 (8%)
leucine-rich repeat 426..450 CDD:275378 3/23 (13%)
LRR_RI <448..651 CDD:238064 50/202 (25%)
leucine-rich repeat 451..474 CDD:275380 2/22 (9%)
LRR_8 473..559 CDD:290566 20/85 (24%)
leucine-rich repeat 475..524 CDD:275380 8/48 (17%)
leucine-rich repeat 500..519 CDD:275380 0/18 (0%)
leucine-rich repeat 525..548 CDD:275380 6/22 (27%)
leucine-rich repeat 549..574 CDD:275380 8/24 (33%)
LRR_8 573..633 CDD:290566 22/59 (37%)
leucine-rich repeat 575..598 CDD:275380 8/22 (36%)
leucine-rich repeat 599..622 CDD:275380 10/22 (45%)
LRR_8 622..683 CDD:290566 7/60 (12%)
leucine-rich repeat 623..646 CDD:275380 7/22 (32%)
leucine-rich repeat 647..730 CDD:275380 8/82 (10%)
leucine-rich repeat 648..673 CDD:275380 0/24 (0%)
leucine-rich repeat 674..705 CDD:275380 0/30 (0%)
LRR_8 704..763 CDD:290566 13/58 (22%)
leucine-rich repeat 731..754 CDD:275380 2/22 (9%)
LRR_8 753..813 CDD:290566 15/59 (25%)
leucine-rich repeat 755..778 CDD:275380 7/22 (32%)
leucine-rich repeat 779..802 CDD:275380 5/22 (23%)
leucine-rich repeat 803..823 CDD:275380 7/19 (37%)
leucine-rich repeat 852..876 CDD:275380 5/23 (22%)
LRR_8 854..910 CDD:290566 16/55 (29%)
LRR_RI <877..>1006 CDD:238064 40/130 (31%)
leucine-rich repeat 877..900 CDD:275380 6/22 (27%)
leucine-rich repeat 901..925 CDD:275380 6/23 (26%)
leucine-rich repeat 926..946 CDD:275380 3/19 (16%)
LRR_8 947..1004 CDD:290566 24/60 (40%)
leucine-rich repeat 947..970 CDD:275380 8/25 (32%)
leucine-rich repeat 971..993 CDD:275380 8/21 (38%)
LRR_8 992..1049 CDD:290566 8/12 (67%)
leucine-rich repeat 994..1014 CDD:275380 7/10 (70%)
leucine-rich repeat 1019..1042 CDD:275380
IGFALSNP_001139478.1 LRRNT 78..116 CDD:214470 3/19 (16%)
leucine-rich repeat 95..113 CDD:275380 3/16 (19%)
leucine-rich repeat 114..137 CDD:275380 9/22 (41%)
leucine-rich repeat 138..161 CDD:275380 5/39 (13%)
LRR_8 141..196 CDD:290566 18/106 (17%)
leucine-rich repeat 162..185 CDD:275380 9/57 (16%)
LRR_8 184..244 CDD:290566 20/85 (24%)
leucine-rich repeat 186..209 CDD:275380 8/48 (17%)
leucine-rich repeat 210..233 CDD:275380 6/22 (27%)
leucine-rich repeat 234..257 CDD:275380 8/24 (33%)
LRR_8 257..316 CDD:290566 22/58 (38%)
leucine-rich repeat 258..281 CDD:275380 8/22 (36%)
leucine-rich repeat 282..305 CDD:275380 10/22 (45%)
leucine-rich repeat 306..324 CDD:275380 5/17 (29%)
LRR_8 336..388 CDD:290566 19/76 (25%)
leucine-rich repeat 354..377 CDD:275380 7/22 (32%)
LRR_8 377..433 CDD:290566 15/55 (27%)
leucine-rich repeat 378..401 CDD:275380 5/22 (23%)
leucine-rich repeat 402..423 CDD:275380 7/20 (35%)
LRR_8 425..484 CDD:290566 13/61 (21%)
leucine-rich repeat 426..447 CDD:275380 2/20 (10%)
leucine-rich repeat 450..473 CDD:275380 6/25 (24%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
LRR_8 476..532 CDD:290566 20/80 (25%)
leucine-rich repeat 498..519 CDD:275380 9/45 (20%)
leucine-rich repeat 522..543 CDD:275380 6/20 (30%)
LRR_8 524..575 CDD:290566 19/53 (36%)
leucine-rich repeat 546..565 CDD:275380 8/21 (38%)
TPKR_C2 574..618 CDD:301599 2/2 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D299282at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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