DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chp and Lrrc4c

DIOPT Version :9

Sequence 1:	NP_001263137.1	Gene:	chp / 43690	FlyBaseID:	FBgn0267435	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001101223.1	Gene:	Lrrc4c / 311236	RGDID:	1311013	Length:	640	Species:	Rattus norvegicus

Alignment Length:	733	Identity:	150/733 - (20%)
Similarity:	256/733 - (34%)	Gaps:	260/733 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 LDFSENGISSIENDAFHEIGHSLISLKMSHGYSGSALPAEPLRHLTSLQELDFSNNHISSMSDTS 542
            |:..||.|..|:.::|                          :||..|:.|..|.|||.::...:
  Rat    81 LNLHENQIQIIKVNSF--------------------------KHLRHLEILQLSRNHIRTIEIGA 119

  Fly   543 FHFLKNLRLLELHDNRIEQVLKGTFQGDIH-SKLEEISLRFNHLTSISQHTFFDLEALRKLHLDD 606
            |:.|.||..|||.|||:..:..|.|   :: |||:|:.||.|.:.||..:.|..:.:||:|.|.:
  Rat   120 FNGLANLNTLELFDNRLTTIPNGAF---VYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGE 181

  Fly   607 -NKIDKIERRAFMNLDELEYLSLRGNKINNLADESFQNLPKLEILDMAFNQLPNFNFDYFDQVGT 670
             .::..|...||..|..|.||        |||..:.:.:|.|..|
  Rat   182 LKRLSYISEGAFEGLSNLRYL--------NLAMCNLREIPNLTPL-------------------- 218

  Fly   671 LSNLNVNVSHNQIRQLMYNSSWSGRNEHGGMYHSNIKI--LDLSHNNISIIHPGYFRPAEISLTH 733
                                               ||:  ||||.|::|.|.||.|:
  Rat   219 -----------------------------------IKLDELDLSGNHLSAIRPGSFQ-------- 240

  Fly   734 LHLGYNSLMNTTRDVFGNMPHLQWLDLSYNWIHELDFDAFKNTKQLQLVFFGHNYLSDIPQDIFK 798
                             .:.|||.|.:..:.|..::.:||.|.:.|..:...||.|:.:|.|:|.
  Rat   241 -----------------GLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFT 288

  Fly   799 PVQGLRIVDFSHN-------------HLRGL-------------PDNL--FYNGGMEK------- 828
            |:..|..:...||             .:|.:             |.||  .|.|.:::
  Rat   289 PLHHLERIHLHHNPWNCNCDILWLSWWIRDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYA 353

  Fly   829 ---------LDVSHNMMLKI---PSSSLSSLAALTLCELHLSNNFISTIHSMDLSNKFRSLRYLD 881
                     |:|:..|..::   .|:||:|::.:|      .|..:.| |.   :.|.|.....|
  Rat   354 PVIVEPPADLNVTEGMAAELKCRASTSLTSVSWIT------PNGTVMT-HG---AYKVRIAVLSD 408

  Fly   882 ISYNYL-LRIDDAVFATMPKLAVLDLSHNRDLKVMDKSFMGLENSLIKLGLENISLSTVPEIRLK 945
            .:.|:. :.:.|....|                .|..:.:|  |:.....|...:.:|.|   ..
  Rat   409 GTLNFTNVTVQDTGMYT----------------CMVSNSVG--NTTASATLNVTAATTTP---FS 452

  Fly   946 YLREFRLGYNELPSIPQELA----HNMSNLRMLDLSNNDLTN--VPLMTQALPHLRRLMLSGNPI 1004
            |.....:...| ||  |:.|    :|:....::|....::|.  .|..|::......:     |:
  Rat   453 YFSTVTVETME-PS--QDEARTTDNNVGPTPVIDWETTNVTTSLTPQSTRSTEKTFTI-----PV 509

  Fly  1005 TSLNNNSFDGVNEDLEMLDISNFRLHYFEYGCLDSLPHLRSLKLTAYSHL--EHFNIPHLLRHHY 1067
            |.: |:...|::|.::...|.        .||..::..:.::.|..:..:  :|    |...||
  Rat   510 TDI-NSGIPGIDEVMKTTKII--------IGCFVAITLMAAVMLVIFYKMRKQH----HRQNHH- 560

  Fly  1068 NIRQLWIEAPQPFTRIVKKGSGPTQEMQTLQLGNPTDLQREMEGHLPSKLTNITFSGPQFTNLNE 1132
                                 .||:.::.:.:.:.......||.|||       ....:..:||.
  Rat   561 ---------------------APTRTVEIINVDDEITGDTPMESHLP-------MPAIEHEHLNH 597

  Fly  1133 RILRGMRSPYLYMQLFNT 1150
              ....:||:.:....||
  Rat   598 --YNSYKSPFNHTTTVNT 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chp	NP_001263137.1	leucine-rich repeat	84..103	CDD:275380
		LRR_8	102..163	CDD:290566
		leucine-rich repeat	104..128	CDD:275380
		LRR_RI	<128..261	CDD:238064
		leucine-rich repeat	129..152	CDD:275380
		LRR_8	152..212	CDD:290566
		leucine-rich repeat	153..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR_8	202..261	CDD:290566
		leucine-rich repeat	202..226	CDD:275380
		leucine-rich repeat	227..250	CDD:275380
		leucine-rich repeat	251..279	CDD:275380
		leucine-rich repeat	280..326	CDD:275380
		LRR_8	326..386	CDD:290566
		leucine-rich repeat	327..348	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		leucine-rich repeat	426..450	CDD:275378
		LRR_RI	<448..651	CDD:238064	52/174 (30%)
		leucine-rich repeat	451..474	CDD:275380
		LRR_8	473..559	CDD:290566	23/80 (29%)
		leucine-rich repeat	475..524	CDD:275380	8/45 (18%)
		leucine-rich repeat	500..519	CDD:275380	0/18 (0%)
		leucine-rich repeat	525..548	CDD:275380	8/22 (36%)
		leucine-rich repeat	549..574	CDD:275380	9/25 (36%)
		LRR_8	573..633	CDD:290566	21/60 (35%)
		leucine-rich repeat	575..598	CDD:275380	8/22 (36%)
		leucine-rich repeat	599..622	CDD:275380	8/23 (35%)
		LRR_8	622..683	CDD:290566	9/60 (15%)
		leucine-rich repeat	623..646	CDD:275380	6/22 (27%)
		leucine-rich repeat	647..730	CDD:275380	14/84 (17%)
		leucine-rich repeat	648..673	CDD:275380	1/24 (4%)
		leucine-rich repeat	674..705	CDD:275380	0/30 (0%)
		LRR_8	704..763	CDD:290566	16/60 (27%)
		leucine-rich repeat	731..754	CDD:275380	0/22 (0%)
		LRR_8	753..813	CDD:290566	19/72 (26%)
		leucine-rich repeat	755..778	CDD:275380	7/22 (32%)
		leucine-rich repeat	779..802	CDD:275380	8/22 (36%)
		leucine-rich repeat	803..823	CDD:275380	7/47 (15%)
		leucine-rich repeat	852..876	CDD:275380	4/23 (17%)
		LRR_8	854..910	CDD:290566	9/56 (16%)
		LRR_RI	<877..>1006	CDD:238064	22/135 (16%)
		leucine-rich repeat	877..900	CDD:275380	4/23 (17%)
		leucine-rich repeat	901..925	CDD:275380	2/23 (9%)
		leucine-rich repeat	926..946	CDD:275380	3/19 (16%)
		LRR_8	947..1004	CDD:290566	10/62 (16%)
		leucine-rich repeat	947..970	CDD:275380	6/26 (23%)
		leucine-rich repeat	971..993	CDD:275380	4/23 (17%)
		LRR_8	992..1049	CDD:290566	8/56 (14%)
		leucine-rich repeat	994..1014	CDD:275380	3/19 (16%)
		leucine-rich repeat	1019..1042	CDD:275380	3/22 (14%)
Lrrc4c	NP_001101223.1	LRRNT	47..80	CDD:214470
		PPP1R42	65..235	CDD:411060	61/245 (25%)
		leucine-rich repeat	78..101	CDD:275380	8/45 (18%)
		leucine-rich repeat	102..125	CDD:275380	8/22 (36%)
		leucine-rich repeat	126..149	CDD:275380	9/25 (36%)
		leucine-rich repeat	150..173	CDD:275380	8/22 (36%)
		leucine-rich repeat	174..198	CDD:275380	8/23 (35%)
		leucine-rich repeat	199..220	CDD:275380	9/83 (11%)
		LRR_8	220..279	CDD:404697	22/83 (27%)
		leucine-rich repeat	221..244	CDD:275380	10/47 (21%)
		leucine-rich repeat	245..268	CDD:275380	7/22 (32%)
		LRR_8	267..>301	CDD:404697	9/33 (27%)
		leucine-rich repeat	269..290	CDD:275380	7/20 (35%)
		LRRCT	301..>339	CDD:214507	5/37 (14%)
		IG	360..443	CDD:214652	21/110 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24369
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010