Protein Alignment chp and GP5

DIOPT Version :10

• Sequence 1: NP_001263137.1
• Gene: chp / 43690
• FlyBaseID: FBgn0267435
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: NP_004479.1
• Gene: GP5 / 2814
• HGNCID: 4443
• Length: 560
• Species: Homo sapiens
• Alignment Length: 411
• Identity: 107/411 - (26%)
• Similarity: 179/411 - (43%)
• Gaps: 57/411 - (13%)

  Fly   508 GYSGSALPAEPLRHLTSLQELDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLKGTFQGDIH 572
            |.....|.::....:|.||.|..|::|||:::..:|..|..|:.|.|..|:|..:     .|.:.
Human    59 GMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHL-----PGALL 118

  Fly   573 SK---LEEISLRFNHLTSISQHTFFDLEALRKLHLDDNKIDKIERRAFMNLDELEYLSLRGNKIN 634
            .|   ||::.|..|.|..|.|:.|..|..|::|.|:.|::|.:....|.||:.|:.|.|.||.:.
Human   119 DKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLT 183

  Fly   635 NLADESFQNLPKLEILDMAFNQLPNFNFDYFDQVGTLSNLNVNVSHNQIRQLMYNSSWSGRNEHG 699
            :|.........|||.|.:..|:|.:.:....:.:|.|:.|..:  .|.||.:.           .
Human   184 HLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFH--RNHIRSIA-----------P 235

  Fly   700 GMYH--SNIKILDLSHNNISIIHPGYFRPAEISLTHLHLGYNSLMNTTRDVFGNMPHLQWLDLSY 762
            |.:.  .|:..|.||.|:::.:....|..:. :||.|.|..|.|......:||.|..||.|.|:.
Human   236 GAFDRLPNLSSLTLSRNHLAFLPSALFLHSH-NLTLLTLFENPLAELPGVLFGEMGGLQELWLNR 299

  Fly   763 NWIHELDFDAFKNTKQLQLVFFGHNY---LSDIPQDIFKPVQGLRIVDFSHNHLRGLPDNLFYN- 823
            ..:..|...||:|..:|:  :.|...   ||.:||..|:.:..|:::....|.|..|||.|...
Human   300 TQLRTLPAAAFRNLSRLR--YLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGL 362

  Fly   824 GGMEKLDVSHNMMLKIPSSSLSSLAALTLCELHLSNNFISTIHSMDLSNKFRSLRYLDISYNYLL 888
            |.:.::.:..|.:..:|.:...:|:                           ||..:.:.:|.|.
Human   363 GKLRQVSLRRNRLRALPRALFRNLS---------------------------SLESVQLDHNQLE 400

  Fly   889 RIDDAVFATMPKLAVLDLSHN 909
            .:...||..:|:|..:.|.||
Human   401 TLPGDVFGALPRLTEVLLGHN 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chp	NP_001263137.1	LRR	<84..320	CDD:443914
		leucine-rich repeat	84..103	CDD:275380
		leucine-rich repeat	104..128	CDD:275380
		leucine-rich repeat	129..152	CDD:275380
		leucine-rich repeat	153..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		leucine-rich repeat	202..226	CDD:275380
		leucine-rich repeat	227..250	CDD:275380
		leucine-rich repeat	251..279	CDD:275380
		leucine-rich repeat	280..326	CDD:275380
		leucine-rich repeat	327..348	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		PPP1R42	355..564	CDD:455733	17/55 (31%)
		leucine-rich repeat	376..401	CDD:275380
		leucine-rich repeat	426..450	CDD:275378
		leucine-rich repeat	451..474	CDD:275380
		LRR_8	473..559	CDD:404697	16/50 (32%)
		leucine-rich repeat	475..524	CDD:275380	2/15 (13%)
		leucine-rich repeat	500..519	CDD:275380	2/10 (20%)
		leucine-rich repeat	525..548	CDD:275380	9/22 (41%)
		LRR	<540..>834	CDD:443914	83/302 (27%)
		leucine-rich repeat	549..574	CDD:275380	6/24 (25%)
		leucine-rich repeat	575..598	CDD:275380	9/22 (41%)
		leucine-rich repeat	599..622	CDD:275380	8/22 (36%)
		leucine-rich repeat	623..646	CDD:275380	6/22 (27%)
		leucine-rich repeat	647..730	CDD:275380	18/84 (21%)
		leucine-rich repeat	648..673	CDD:275380	6/24 (25%)
		leucine-rich repeat	674..705	CDD:275380	5/32 (16%)
		LRR	<730..1081	CDD:443914	46/184 (25%)
		leucine-rich repeat	731..754	CDD:275380	9/22 (41%)
		leucine-rich repeat	755..778	CDD:275380	8/22 (36%)
		leucine-rich repeat	779..802	CDD:275380	7/25 (28%)
		leucine-rich repeat	803..823	CDD:275380	7/19 (37%)
		leucine-rich repeat	852..876	CDD:275380	0/23 (0%)
		leucine-rich repeat	877..900	CDD:275380	5/22 (23%)
		leucine-rich repeat	901..925	CDD:275380	4/9 (44%)
		leucine-rich repeat	926..946	CDD:275380
		leucine-rich repeat	947..970	CDD:275380
		leucine-rich repeat	971..993	CDD:275380
		leucine-rich repeat	994..1014	CDD:275380
		leucine-rich repeat	1019..1042	CDD:275380
GP5	NP_004479.1	LRR	<44..>299	CDD:443914	74/258 (29%)
		LRR 1	75..96		8/20 (40%)
		leucine-rich repeat	76..99	CDD:275380	9/22 (41%)
		LRR 2	99..120		6/25 (24%)
		leucine-rich repeat	100..123	CDD:275380	7/27 (26%)
		LRR 3	123..144		8/20 (40%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		LRR 4	147..168		6/20 (30%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		LRR 5	171..193		6/21 (29%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		LRR 6	195..216		6/20 (30%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		LRR 7	219..240		6/33 (18%)
		leucine-rich repeat	220..243	CDD:275380	6/35 (17%)
		LRR 8	243..264		6/20 (30%)
		leucine-rich repeat	244..267	CDD:275380	5/23 (22%)
		LRR 9	267..288		7/20 (35%)
		leucine-rich repeat	268..291	CDD:275380	9/22 (41%)
		LRR_8	291..351	CDD:404697	17/61 (28%)
		LRR 10	291..312		7/20 (35%)
		leucine-rich repeat	292..315	CDD:275380	8/22 (36%)
		leucine-rich repeat	316..338	CDD:275380	7/23 (30%)
		LRR_8	340..399	CDD:404697	14/85 (16%)
		LRR 11	340..361		7/20 (35%)
		leucine-rich repeat	341..364	CDD:275380	7/22 (32%)
		LRR 12	364..385		2/20 (10%)
		leucine-rich repeat	365..388	CDD:275380	3/49 (6%)
		LRR 13	388..409		6/20 (30%)
		leucine-rich repeat	389..410	CDD:275380	5/20 (25%)
		LRRCT	421..472	CDD:214507	1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	469..498