DRSC/TRiP Functional Genomics Resources

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Protein Alignment chp and Igfals

DIOPT Version :9

Sequence 1:NP_001263137.1 Gene:chp / 43690 FlyBaseID:FBgn0267435 Length:1338 Species:Drosophila melanogaster
Sequence 2:NP_001351825.1 Gene:Igfals / 16005 MGIID:107973 Length:638 Species:Mus musculus


Alignment Length:631 Identity:165/631 - (26%)
Similarity:252/631 - (39%) Gaps:138/631 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 ITLMIMIWMSLARASMFDRE---MEETHYPPCTYNVMCTCSKSS-TDLGIVHCKNVPFPALPRMV 76
            :.:::..|::|....:...:   ..:...|.|.  |.||||... ||...|.|.:.....||..:
Mouse    45 LVVLLAFWVALGPCYLQGTDPGASADAEGPQCP--VTCTCSYDDYTDELSVFCSSRNLTQLPDSI 107

  Fly    77 -----------------------NQSKVFMLHMENTGLREIEPY-FLQSTGMYRLKISGNHLTEI 117
                                   |.|.:..|:::.:.||.:||. .|....:|.|.:..|.|..:
Mouse   108 PVSTRALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLLRSL 172

  Fly   118 PDDAFTGLER---SLWELILPQNDLVEIPSKSLRHLQKLRHLDLGYNHITHIQHDSFRGLEDSLQ 179
            .    .||.|   ||..|.|..|.|..:.....|.|..|..|:||:|.:..:....|:|| .:|.
Mouse   173 A----AGLFRHTPSLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGL-GNLH 232

  Fly   180 TLILRENCISQLMSHSFSGLLILETLDLSGNNLFEIDPNVFVDGMPRLTRLLLTDNILSEIPYDA 244
            .|:|..|.::.|......||..|..||||.|.|..:..|||:. :|||.:|.|..|:::.:...|
Mouse   233 ELVLAGNKLTYLQPALLCGLGELRELDLSRNALRSVKANVFIH-LPRLQKLYLDRNLITAVAPRA 296

  Fly   245 LGPLKSLRTLDISHNVIWSLSGNETYEIKASTKLNLDNLHLEYNHIEVLPPNSFKYFDTVNRTFF 309
            ...:|:||.||:|||.:..|. .:|:    ...|.|..|.|.:|.|..|.|.:||          
Mouse   297 FLGMKALRWLDLSHNRVAGLL-EDTF----PGLLGLHVLRLAHNAITSLRPRTFK---------- 346

  Fly   310 DGNPIHTLREDAFKPARIREIYMRYCGLTNISPVAFDSLVNSLQILDLSGNNLTKLHHKLFNNFD 374
               .:|.|.|                                   |.|..|.:.:|..|.|....
Mouse   347 ---DLHFLEE-----------------------------------LQLGHNRIRQLGEKTFEGLG 373

  Fly   375 VLRVISMRDNKIKIQKPTETFNAVHYTLLKLDLSGDRNDPTNLQTLRKMRNMRSLSISRLGSSSV 439
            .|.|:::.||:|...|....|..  :.:..::|||:              .:|||          
Mouse   374 QLEVLTLNDNQIHEVKVGAFFGL--FNVAVMNLSGN--------------CLRSL---------- 412

  Fly   440 GPED-FKDFGVELEDLQITRASLSGIQSHAFKHVRGLKRLDFSENGISSIENDAFHEIGH----S 499
             ||. |:..| .|..|.:..:.|..|:.|.|..:.||:||...:|.|||||..:...:..    .
Mouse   413 -PEHVFQGLG-RLHSLHLEHSCLGRIRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELD 475

  Fly   500 LISLKMSHGYSGSALPAEPLRHLTSLQELDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLK 564
            |.:.:::|      ||.:..:.|..|:.|..|||.::.:|:.....|:....|:|..||:|...:
Mouse   476 LTANQLTH------LPRQLFQGLGQLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAE 534

  Fly   565 GTFQGDIHSKLEEISLRFNHLTSISQHTFFDLEALRKLHLDDNKID 610
            |.|     |.|..  ||:.:|.:.|..||.....|.:|.||.|..|
Mouse   535 GLF-----SSLGR--LRYLNLRNNSLQTFVPQPGLERLWLDANPWD 573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chpNP_001263137.1 leucine-rich repeat 84..103 CDD:275380 6/19 (32%)
LRR_8 102..163 CDD:290566 20/63 (32%)
leucine-rich repeat 104..128 CDD:275380 7/26 (27%)
LRR_RI <128..261 CDD:238064 48/132 (36%)
leucine-rich repeat 129..152 CDD:275380 7/22 (32%)
LRR_8 152..212 CDD:290566 21/59 (36%)
leucine-rich repeat 153..177 CDD:275380 8/23 (35%)
leucine-rich repeat 178..201 CDD:275380 7/22 (32%)
LRR_8 202..261 CDD:290566 25/58 (43%)
leucine-rich repeat 202..226 CDD:275380 10/23 (43%)
leucine-rich repeat 227..250 CDD:275380 5/22 (23%)
leucine-rich repeat 251..279 CDD:275380 9/27 (33%)
leucine-rich repeat 280..326 CDD:275380 12/45 (27%)
LRR_8 326..386 CDD:290566 10/59 (17%)
leucine-rich repeat 327..348 CDD:275380 0/20 (0%)
leucine-rich repeat 352..375 CDD:275380 6/22 (27%)
leucine-rich repeat 376..401 CDD:275380 7/24 (29%)
leucine-rich repeat 426..450 CDD:275378 7/24 (29%)
LRR_RI <448..651 CDD:238064 50/167 (30%)
leucine-rich repeat 451..474 CDD:275380 6/22 (27%)
LRR_8 473..559 CDD:290566 25/89 (28%)
leucine-rich repeat 475..524 CDD:275380 14/52 (27%)
leucine-rich repeat 500..519 CDD:275380 4/18 (22%)
leucine-rich repeat 525..548 CDD:275380 7/22 (32%)
leucine-rich repeat 549..574 CDD:275380 7/24 (29%)
LRR_8 573..633 CDD:290566 14/38 (37%)
leucine-rich repeat 575..598 CDD:275380 7/22 (32%)
leucine-rich repeat 599..622 CDD:275380 6/12 (50%)
LRR_8 622..683 CDD:290566
leucine-rich repeat 623..646 CDD:275380
leucine-rich repeat 647..730 CDD:275380
leucine-rich repeat 648..673 CDD:275380
leucine-rich repeat 674..705 CDD:275380
LRR_8 704..763 CDD:290566
leucine-rich repeat 731..754 CDD:275380
LRR_8 753..813 CDD:290566
leucine-rich repeat 755..778 CDD:275380
leucine-rich repeat 779..802 CDD:275380
leucine-rich repeat 803..823 CDD:275380
leucine-rich repeat 852..876 CDD:275380
LRR_8 854..910 CDD:290566
LRR_RI <877..>1006 CDD:238064
leucine-rich repeat 877..900 CDD:275380
leucine-rich repeat 901..925 CDD:275380
leucine-rich repeat 926..946 CDD:275380
LRR_8 947..1004 CDD:290566
leucine-rich repeat 947..970 CDD:275380
leucine-rich repeat 971..993 CDD:275380
LRR_8 992..1049 CDD:290566
leucine-rich repeat 994..1014 CDD:275380
leucine-rich repeat 1019..1042 CDD:275380
IgfalsNP_001351825.1 LRRNT 75..113 CDD:214470 12/39 (31%)
leucine-rich repeat 92..110 CDD:275380 4/17 (24%)
PLN00113 96..>558 CDD:331614 146/561 (26%)
leucine-rich repeat 114..134 CDD:275380 1/19 (5%)
leucine-rich repeat 135..158 CDD:275380 6/22 (27%)
leucine-rich repeat 159..182 CDD:275380 7/26 (27%)
leucine-rich repeat 183..206 CDD:275380 7/22 (32%)
leucine-rich repeat 207..230 CDD:275380 8/23 (35%)
leucine-rich repeat 231..254 CDD:275380 7/22 (32%)
leucine-rich repeat 255..278 CDD:275380 10/23 (43%)
leucine-rich repeat 279..302 CDD:275380 5/22 (23%)
leucine-rich repeat 303..326 CDD:275380 9/27 (33%)
leucine-rich repeat 327..350 CDD:275380 9/35 (26%)
leucine-rich repeat 351..374 CDD:275380 8/57 (14%)
leucine-rich repeat 375..396 CDD:275380 7/20 (35%)
leucine-rich repeat 423..446 CDD:275380 6/22 (27%)
leucine-rich repeat 447..470 CDD:275380 9/22 (41%)
leucine-rich repeat 471..494 CDD:275380 5/28 (18%)
leucine-rich repeat 495..516 CDD:275380 6/20 (30%)
leucine-rich repeat 519..542 CDD:275380 9/27 (33%)
leucine-rich repeat 543..561 CDD:275380 6/17 (35%)
TPKR_C2 570..613 CDD:326558 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42484
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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