DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chp and LRRC53

DIOPT Version :9

Sequence 1:	NP_001263137.1	Gene:	chp / 43690	FlyBaseID:	FBgn0267435	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001369209.1	Gene:	LRRC53 / 105378803	HGNCID:	25255	Length:	1247	Species:	Homo sapiens

Alignment Length:	814	Identity:	178/814 - (21%)
Similarity:	277/814 - (34%)	Gaps:	244/814 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   528 LDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLKGTFQGDIHSKLEEISLRFNHL--TSISQ 590
            |..::.::||:..|:...|.||.||.|..|.||.|.:....|  .:.|..:.|..|.:  :|::.
Human    38 LIITDGYLSSIESTNLSLLFNLALLSLSRNGIEDVQEDALHG--LTMLRTLLLEHNQISSSSLTD 100

  Fly   591 HTFFDLEALRKLHLDDNKIDKIERRAFMNLDELEYLSLRGNKINNLADESFQNLPKLEILDMAFN 655
            |||..|.:|:.|.|.:|.:..:....|.|...|..|.|.||:|.||.|.||
Human   101 HTFSKLHSLQVLVLSNNALRTLRGSWFRNTSGLTRLQLDGNQITNLTDSSF-------------- 151

  Fly   656 QLPNFNFDYFDQVGTLSNLNVNVSHNQIRQLMYNSSWSGRNEHGGMYHSNIKILDLSHNNISIIH 720
                                                 .|.|.|      :::.||||:|.||.|.
Human   152 -------------------------------------GGTNLH------SLRYLDLSNNFISYIG 173

  Fly   721 PGYFRPAEISLTHLHLGYNSLMNTTRDVFGNMPHLQWLDLSYNWIHELDFDAFKNTKQLQLVFFG 785
            ...|||                         :|.||.:|||.|.:..:. |.|...|||.|:...
Human   174 KDAFRP-------------------------LPQLQEVDLSRNRLAHMP-DVFTPLKQLILLSLD 212

  Fly   786 HNYLSDIPQDIFKPVQGLR-IVDFSHNHLRGLPDNLFYNGGMEKLDVSHNMMLKIPSSSLSSLAA 849
            .|..| ...|:....:.|| .:..|.:.||...|                  |....|:.:..||
Human   213 KNQWS-CTCDLHPLARFLRNYIKSSAHTLRNAKD------------------LNCQPSTAAVAAA 258

  Fly   850 LTLCELHLSN------NFISTIHSMDLSNKFRSLRYLDISYNYLLRIDDAVFATMPKLAVLDLSH 908
            .::..|..:|      ||     ::.|.::...|...|::...:|....||..|...|.|.:.
Human   259 QSVLRLSETNCDSKAPNF-----TLVLKDRSPLLPGPDVALLTVLGFAGAVGLTCLGLVVFNW-- 316

  Fly   909 NRDLKVMDKSFMGLENSLIKLGLENISLSTVPEIRLKYLREFRLGYNELPSIPQELAHNMSNLRM 973
                    |...|..|....   ||:...|..|                    ...||...|...
Human   317 --------KLHQGKANEHTS---ENLCCRTFDE--------------------PLCAHEARNYHT 350

  Fly   974 LDLSNNDLT---NVPLMT-----QALPHLRRLMLSGNPITSLNNN-SFDGVNEDLEMLD------ 1023
            ....|..||   .:.:|:     :.:|.|:.   :.:..||.:.: :.||...:|:..|
Human   351 KGYCNCHLTQENEIKVMSTVGSRKEMPLLQE---NSHQATSASESATLDGSFRNLKKKDRGVGST 412

  Fly  1024 --ISNFRLHYFEYGCLDSLPHLRSLK----LTAYS--------HLEHFNI-PHLLRHHYNIRQLW 1073
              ..:.||.:.|  |.:...::|:..    ||.|:        :||...: |..|:||. ||...
Human   413 LFCQDGRLLHSE--CSEPPGNMRAFNEAGLLTTYNPRKVQKLWNLEPGEVQPQTLQHHI-IRTED 474

  Fly  1074 IEAPQPFTRIVKKGSGPTQEMQTLQLGNPT---DLQREMEGHLPSKLTN-ITFSGPQFTNLNE-- 1132
            |.:.....|.....|....|....:|.|.:   .:::|..|..|.:..: ||.|..:.....|
Human   475 ISSDIFRRRYATPASALAGESLEKRLTNESWQPPIEKEDNGLHPHRQRHFITSSSSKPCEPEEHY 539

  Fly  1133 --RILRGMRSPY------------LYMQLFNTSLQALPP--NFFKYMGRVRNISLDIRYHNRNLK 1181
              :|::..||.|            .|.|..|:.:....|  .|..||   :....:.|.|::..|
Human   540 VQKIVQKNRSKYDDPCGLLKQSKPRYFQPNNSLICKYVPCEQFEDYM---KEKKPNRRQHSKPEK 601

  Fly  1182 KIPNPNTGAVPYLPN------SVFLTDLKMSHTDLNC---DCDLGWVEF------------WQRK 1225
            :....|:....:|.:      |...|..|.:::....   |.||  ||.            |:|:
Human   602 EQIQINSAIEKFLMSEDNIDLSGLSTKTKKAYSPKRVIFHDPDL--VEINRSMMSPKISTPWKRQ 664

  Fly  1226 RRQYICSSQTWTDTVFRTFMNSPCQVYGRHNCDE 1259
            :.|    |...|....:.|.|:     |..|..|
Human   665 KNQ----SNQLTKLDVKKFSNT-----GERNKGE 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chp	NP_001263137.1	leucine-rich repeat	84..103	CDD:275380
		LRR_8	102..163	CDD:290566
		leucine-rich repeat	104..128	CDD:275380
		LRR_RI	<128..261	CDD:238064
		leucine-rich repeat	129..152	CDD:275380
		LRR_8	152..212	CDD:290566
		leucine-rich repeat	153..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR_8	202..261	CDD:290566
		leucine-rich repeat	202..226	CDD:275380
		leucine-rich repeat	227..250	CDD:275380
		leucine-rich repeat	251..279	CDD:275380
		leucine-rich repeat	280..326	CDD:275380
		LRR_8	326..386	CDD:290566
		leucine-rich repeat	327..348	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		leucine-rich repeat	426..450	CDD:275378
		LRR_RI	<448..651	CDD:238064	40/124 (32%)
		leucine-rich repeat	451..474	CDD:275380
		LRR_8	473..559	CDD:290566	11/30 (37%)
		leucine-rich repeat	475..524	CDD:275380
		leucine-rich repeat	500..519	CDD:275380
		leucine-rich repeat	525..548	CDD:275380	5/19 (26%)
		leucine-rich repeat	549..574	CDD:275380	9/24 (38%)
		LRR_8	573..633	CDD:290566	19/61 (31%)
		leucine-rich repeat	575..598	CDD:275380	8/24 (33%)
		leucine-rich repeat	599..622	CDD:275380	6/22 (27%)
		LRR_8	622..683	CDD:290566	11/60 (18%)
		leucine-rich repeat	623..646	CDD:275380	11/22 (50%)
		leucine-rich repeat	647..730	CDD:275380	14/82 (17%)
		leucine-rich repeat	648..673	CDD:275380	0/24 (0%)
		leucine-rich repeat	674..705	CDD:275380	3/30 (10%)
		LRR_8	704..763	CDD:290566	17/58 (29%)
		leucine-rich repeat	731..754	CDD:275380	0/22 (0%)
		LRR_8	753..813	CDD:290566	19/60 (32%)
		leucine-rich repeat	755..778	CDD:275380	8/22 (36%)
		leucine-rich repeat	779..802	CDD:275380	5/22 (23%)
		leucine-rich repeat	803..823	CDD:275380	6/20 (30%)
		leucine-rich repeat	852..876	CDD:275380	5/29 (17%)
		LRR_8	854..910	CDD:290566	13/61 (21%)
		LRR_RI	<877..>1006	CDD:238064	24/136 (18%)
		leucine-rich repeat	877..900	CDD:275380	6/22 (27%)
		leucine-rich repeat	901..925	CDD:275380	4/23 (17%)
		leucine-rich repeat	926..946	CDD:275380	4/19 (21%)
		LRR_8	947..1004	CDD:290566	9/64 (14%)
		leucine-rich repeat	947..970	CDD:275380	2/22 (9%)
		leucine-rich repeat	971..993	CDD:275380	4/29 (14%)
		LRR_8	992..1049	CDD:290566	13/69 (19%)
		leucine-rich repeat	994..1014	CDD:275380	3/20 (15%)
		leucine-rich repeat	1019..1042	CDD:275380	6/30 (20%)
LRRC53	NP_001369209.1	LRR 1	34..55		4/16 (25%)
		LRR 2	58..79		9/20 (45%)
		LRR 3	82..102		4/19 (21%)
		LRR_8	83..143	CDD:404697	19/59 (32%)
		leucine-rich repeat	83..108	CDD:275380	8/24 (33%)
		LRR 4	108..129		5/20 (25%)
		leucine-rich repeat	109..132	CDD:275380	6/22 (27%)
		LRR_8	131..193	CDD:404697	32/143 (22%)
		LRR 5	132..153		11/71 (15%)
		leucine-rich repeat	133..158	CDD:275380	14/81 (17%)
		LRR 6	158..179		9/20 (45%)
		leucine-rich repeat	159..182	CDD:275380	11/47 (23%)
		LRR 7	182..203		8/21 (38%)
		leucine-rich repeat	183..205	CDD:275380	8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	828..866
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..927
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1223..1247
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24369
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100