DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment chp and lrrtm2

DIOPT Version :9

Sequence 1:	NP_001263137.1	Gene:	chp / 43690	FlyBaseID:	FBgn0267435	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001338621.1	Gene:	lrrtm2 / 100538061	ZFINID:	ZDB-GENE-080327-8	Length:	542	Species:	Danio rerio

Alignment Length:	354	Identity:	98/354 - (27%)
Similarity:	152/354 - (42%)	Gaps:	57/354 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 VGPEDFKDFGVELEDLQITRASLSGIQSHAFKHVRGLKRLDFSENGISSIENDAFHEIGHSLISL 503
            :.|.|..|.|.  ..|.:...|:|.:.|..|.....|..|....|.|:::..|||..: :.|..|
Zfish    53 LAPPDGVDKGA--LGLSLRHNSISELSSDQFFGFTQLTWLHLDHNQITTVHEDAFQGL-YKLKDL 114

  Fly   504 KMSHGYSGSALPAEPLRHLTSLQELDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLKGTFQ 568
            .:|.... :.||.....||.:||.||.|.|.::::....||.|:.|::|.|..|.:.......|
Zfish   115 NLSSNRI-TKLPNTTFIHLINLQILDLSFNQMTALEPELFHGLRKLQILHLRSNSLRTTPVRAF- 177

  Fly   569 GDIHSKLEEISLRFNHLTSISQHTFFDLEALRKLHLDDNKIDKIERRAFMNLDELEYLSLRGNKI 633
            .|..| ||.:.|..|.|.|::::.|..|..||:|||:.|.:.||....|..|..|::|.|:.|||
Zfish   178 WDCRS-LEYLGLSNNRLRSLARNGFAGLIKLRELHLEHNHLTKINLAHFPRLVALQFLYLQWNKI 241

  Fly   634 NNLAD------------------------ESFQNLPKLEILDMAFNQLPNFNFDYFDQVGTLSNL 674
            |||..                        |.|:.||.|:||.:..|:|.|.:....|...:|:.:
Zfish   242 NNLTSTMEWKWTTLEKLDLTGNEIRVLIPEVFETLPSLKILLLDNNKLSNLDSQTMDMWKSLNVI 306

  Fly   675 NVNVSHNQIRQLMYN-----SSWSGRNEHGGM-----YHSNIKILD------LSHNNISIIHPGY 723
            .::.:..:..:.:.|     |::.||.||..:     |....:|||      |..|        :
Zfish   307 GLSSNLWECTKRICNLATWLSTFKGRWEHSILCYSPEYAQGEEILDAVYGFQLCQN--------F 363

  Fly   724 FRPAEISLTHLHLGYNSLMNTTRDVFGNM 752
            ..|..::.|....   .|.:.|..:||||
Zfish   364 SAPVVLTSTSTEA---MLPDITSSLFGNM 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chp	NP_001263137.1	leucine-rich repeat	84..103	CDD:275380
		LRR_8	102..163	CDD:290566
		leucine-rich repeat	104..128	CDD:275380
		LRR_RI	<128..261	CDD:238064
		leucine-rich repeat	129..152	CDD:275380
		LRR_8	152..212	CDD:290566
		leucine-rich repeat	153..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR_8	202..261	CDD:290566
		leucine-rich repeat	202..226	CDD:275380
		leucine-rich repeat	227..250	CDD:275380
		leucine-rich repeat	251..279	CDD:275380
		leucine-rich repeat	280..326	CDD:275380
		LRR_8	326..386	CDD:290566
		leucine-rich repeat	327..348	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		leucine-rich repeat	426..450	CDD:275378	4/10 (40%)
		LRR_RI	<448..651	CDD:238064	69/226 (31%)
		leucine-rich repeat	451..474	CDD:275380	5/22 (23%)
		LRR_8	473..559	CDD:290566	27/85 (32%)
		leucine-rich repeat	475..524	CDD:275380	14/48 (29%)
		leucine-rich repeat	500..519	CDD:275380	5/18 (28%)
		leucine-rich repeat	525..548	CDD:275380	9/22 (41%)
		leucine-rich repeat	549..574	CDD:275380	6/24 (25%)
		LRR_8	573..633	CDD:290566	23/59 (39%)
		leucine-rich repeat	575..598	CDD:275380	8/22 (36%)
		leucine-rich repeat	599..622	CDD:275380	10/22 (45%)
		LRR_8	622..683	CDD:290566	21/84 (25%)
		leucine-rich repeat	623..646	CDD:275380	12/46 (26%)
		leucine-rich repeat	647..730	CDD:275380	21/98 (21%)
		leucine-rich repeat	648..673	CDD:275380	7/24 (29%)
		leucine-rich repeat	674..705	CDD:275380	7/40 (18%)
		LRR_8	704..763	CDD:290566	13/55 (24%)
		leucine-rich repeat	731..754	CDD:275380	7/22 (32%)
		LRR_8	753..813	CDD:290566	98/354 (28%)
		leucine-rich repeat	755..778	CDD:275380
		leucine-rich repeat	779..802	CDD:275380
		leucine-rich repeat	803..823	CDD:275380
		leucine-rich repeat	852..876	CDD:275380
		LRR_8	854..910	CDD:290566
		LRR_RI	<877..>1006	CDD:238064
		leucine-rich repeat	877..900	CDD:275380
		leucine-rich repeat	901..925	CDD:275380
		leucine-rich repeat	926..946	CDD:275380
		LRR_8	947..1004	CDD:290566
		leucine-rich repeat	947..970	CDD:275380
		leucine-rich repeat	971..993	CDD:275380
		LRR_8	992..1049	CDD:290566
		leucine-rich repeat	994..1014	CDD:275380
		leucine-rich repeat	1019..1042	CDD:275380
lrrtm2	NP_001338621.1	LRR_8	66..121	CDD:316378	15/55 (27%)
		leucine-rich repeat	66..86	CDD:275380	5/19 (26%)
		leucine-rich repeat	87..110	CDD:275380	7/23 (30%)
		LRR	<108..>295	CDD:227223	60/190 (32%)
		leucine-rich repeat	111..134	CDD:275380	7/23 (30%)
		leucine-rich repeat	135..158	CDD:275380	9/22 (41%)
		leucine-rich repeat	159..182	CDD:275380	6/23 (26%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		leucine-rich repeat	255..278	CDD:275380	3/22 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24369
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100