DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment chp and lrrc4bb

DIOPT Version :9

Sequence 1:	NP_001263137.1	Gene:	chp / 43690	FlyBaseID:	FBgn0267435	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	XP_003201401.1	Gene:	lrrc4bb / 100535350	ZFINID:	ZDB-GENE-091116-44	Length:	726	Species:	Danio rerio

Alignment Length:	332	Identity:	82/332 - (24%)
Similarity:	131/332 - (39%)	Gaps:	94/332 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 TRASLSGIQSHAFKHVRGLKRLDFSENGISSIENDAFHEIGHSLISLKMSHGYSGSALPAEPLRH 521
            |:.||:.:......:.|   .|:..||.|..|.:|.|                          :|
Zfish    55 TKKSLNEVPQSISSNTR---YLNLQENSIQVIRSDTF--------------------------KH 90

  Fly   522 LTSLQELDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLKGTFQGDIHSKLEEISLRFNHLT 586
            |..|:.|..|.|.|..:...:|:.|.||..|||.|||:..|....|  :..|||.|:.||.|.:.
Zfish    91 LNHLEILQLSKNQIRQIEVGAFNGLPNLITLELFDNRLPLVPSQAF--EYLSKLRELWLRNNPIE 153

  Fly   587 SISQHTFFDLEALRKLHLDD-NKIDKIERRAFMNLDELEYLSLRGNKINNLADESFQNLPKLEIL 650
            ::..:.|..:.:||:|.|.: .|:..|...||..|..|.:|        ||.....:::|.|..|
Zfish   154 TLPAYAFHRVPSLRRLDLGELRKLSFISEAAFEGLLNLRFL--------NLGMCGLKDVPNLTPL 210

  Fly   651 DMAFNQLPNFNFDYFDQVGTLSNLNVNVSHNQIRQLMYNSSWSGRNEHGGMYHSNIKILDLSHNN 715
                                            :|                     ::.|:||.|.
Zfish   211 --------------------------------VR---------------------LEELELSGNQ 222

  Fly   716 ISIIHPGYFRPAEISLTHLHLGYNSLMNTTRDVFGNMPHLQWLDLSYNWIHELDFDAFKNTKQLQ 780
            :.::.||.|: ..:||..|.|.::.:....|:.|.::.:|:.|:||:|.:|.|..|.|...:||:
Zfish   223 LGVVRPGSFQ-GLVSLRKLWLMHSRISVIERNAFDDLKNLEELNLSHNSLHSLPHDLFTPLQQLE 286

  Fly   781 LVFFGHN 787
            .|...||
Zfish   287 RVHLNHN 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chp	NP_001263137.1	leucine-rich repeat	84..103	CDD:275380
		LRR_8	102..163	CDD:290566
		leucine-rich repeat	104..128	CDD:275380
		LRR_RI	<128..261	CDD:238064
		leucine-rich repeat	129..152	CDD:275380
		LRR_8	152..212	CDD:290566
		leucine-rich repeat	153..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR_8	202..261	CDD:290566
		leucine-rich repeat	202..226	CDD:275380
		leucine-rich repeat	227..250	CDD:275380
		leucine-rich repeat	251..279	CDD:275380
		leucine-rich repeat	280..326	CDD:275380
		LRR_8	326..386	CDD:290566
		leucine-rich repeat	327..348	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		leucine-rich repeat	426..450	CDD:275378
		LRR_RI	<448..651	CDD:238064	53/194 (27%)
		leucine-rich repeat	451..474	CDD:275380	3/16 (19%)
		LRR_8	473..559	CDD:290566	24/85 (28%)
		leucine-rich repeat	475..524	CDD:275380	9/48 (19%)
		leucine-rich repeat	500..519	CDD:275380	0/18 (0%)
		leucine-rich repeat	525..548	CDD:275380	7/22 (32%)
		leucine-rich repeat	549..574	CDD:275380	9/24 (38%)
		LRR_8	573..633	CDD:290566	19/60 (32%)
		leucine-rich repeat	575..598	CDD:275380	6/22 (27%)
		leucine-rich repeat	599..622	CDD:275380	9/23 (39%)
		LRR_8	622..683	CDD:290566	7/60 (12%)
		leucine-rich repeat	623..646	CDD:275380	4/22 (18%)
		leucine-rich repeat	647..730	CDD:275380	10/82 (12%)
		leucine-rich repeat	648..673	CDD:275380	1/24 (4%)
		leucine-rich repeat	674..705	CDD:275380	1/30 (3%)
		LRR_8	704..763	CDD:290566	17/58 (29%)
		leucine-rich repeat	731..754	CDD:275380	5/22 (23%)
		LRR_8	753..813	CDD:290566	14/35 (40%)
		leucine-rich repeat	755..778	CDD:275380	9/22 (41%)
		leucine-rich repeat	779..802	CDD:275380	4/9 (44%)
		leucine-rich repeat	803..823	CDD:275380
		leucine-rich repeat	852..876	CDD:275380
		LRR_8	854..910	CDD:290566
		LRR_RI	<877..>1006	CDD:238064
		leucine-rich repeat	877..900	CDD:275380
		leucine-rich repeat	901..925	CDD:275380
		leucine-rich repeat	926..946	CDD:275380
		LRR_8	947..1004	CDD:290566
		leucine-rich repeat	947..970	CDD:275380
		leucine-rich repeat	971..993	CDD:275380
		LRR_8	992..1049	CDD:290566
		leucine-rich repeat	994..1014	CDD:275380
		leucine-rich repeat	1019..1042	CDD:275380
lrrc4bb	XP_003201401.1	LRRNT	38..72	CDD:214470	4/19 (21%)
		LRR_8	68..128	CDD:290566	24/88 (27%)
		leucine-rich repeat	70..93	CDD:275380	10/51 (20%)
		LRR_RI	85..293	CDD:238064	71/297 (24%)
		leucine-rich repeat	94..117	CDD:275380	7/22 (32%)
		leucine-rich repeat	118..141	CDD:275380	9/24 (38%)
		LRR_8	140..196	CDD:290566	19/63 (30%)
		leucine-rich repeat	142..165	CDD:275380	6/22 (27%)
		leucine-rich repeat	166..190	CDD:275380	9/23 (39%)
		leucine-rich repeat	191..212	CDD:275380	7/60 (12%)
		LRR_8	212..271	CDD:290566	19/80 (24%)
		leucine-rich repeat	213..236	CDD:275380	7/23 (30%)
		leucine-rich repeat	237..260	CDD:275380	5/22 (23%)
		leucine-rich repeat	261..282	CDD:275380	9/20 (45%)
		TPKR_C2	293..343	CDD:301599	1/1 (100%)
		IG_like	352..435	CDD:214653
		Ig	360..435	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24369
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010