DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1544 and OGDHL

DIOPT Version :9

Sequence 1:	NP_651849.1	Gene:	CG1544 / 43689	FlyBaseID:	FBgn0039827	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_001334748.1	Gene:	OGDHL / 55753	HGNCID:	25590	Length:	1010	Species:	Homo sapiens

Alignment Length:	970	Identity:	344/970 - (35%)
Similarity:	530/970 - (54%)	Gaps:	121/970 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PRPQSRCYHSEKGVWGYKPIAQREFQVAEDVRASRNSQANVYRFVEAFRQHGHKLAAVNPISIRT 80
            |||.|..:.|...|    ....:..::.||..|       |...:.|::..||.:|.::|:.|..
Human    88 PRPPSVVHESRSAV----SSRTKTSKLVEDHLA-------VQSLIRAYQIRGHHVAQLDPLGILD 141

  Fly    81 SQQELQELSP----------AFYGLQT-------QEPVRTDGLLSGPQVAHNVAQLEQLLKDIYC 128
            :  :|....|          |||.||.       |.|..|  .:.|.:...::.::.:.|::.||
Human   142 A--DLDSFVPSDLITTIDKLAFYDLQEADLDKEFQLPTTT--FIGGSENTLSLREIIRRLENTYC 202

  Fly   129 GRSTSAEFSYVEDIEEREWLARNFETLDQQQLGKSERCEIAELLIKSQAWDNFMALKFPTVKRYG 193
             :....||.::.|:|:.:|:.:.|||....|....|:..:...|::|..:::|:|.|:.:.||:|
Human   203 -QHIGLEFMFINDVEQCQWIRQKFETPGVMQFSSEEKRTLLARLVRSMRFEDFLARKWSSEKRFG 266

  Fly   194 GEGAESMLAFFWQLLRDSVQANIEHVVLAMPHRGRTPLQAALLNMRPAKVF----RKLSGASEFS 254
            .||.|.|:.....::..|.:..||:|:|.||||||..:.|.::.....::|    .||..|.|.|
Human   267 LEGCEVMIPALKTIIDKSSEMGIENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGS 331

  Fly   255 EDIEAMSDVISHFHVS---EQL-KILGKKLSFSMVRNPSHLEAANPVAMGKTRSKQQARGEGAFG 315
            .|::        :|:.   |:: ::..:.::.|:|.|||||||.:||..|||:::|..||:..
Human   332 GDVK--------YHLGMYHERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQ-- 386

  Fly   316 DGSQPFGEHVLNVILHGDAAFAGQGINQECLNMAYVPHFEVGGSLHLIVNNQVGFTTPGDRGRST 380
                  |:.|:::::||||||||||:..|..:::.:|.:...|::|::||||:||||.....||:
Human   387 ------GKKVMSILVHGDAAFAGQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSS 445

  Fly   381 AYTSDLAKSIQAPVFHVNGDDPEALARVTSLAFRYQREFRKDIFIDLNCFRRWGHNELDDPTFTN 445
            .|.:|:|:.:.||:||||.|||||:..|.|:|..::..|.||:.:||.|:||.||||:|:|.||.
Human   446 PYPTDVARVVNAPIFHVNADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQ 510

  Fly   446 PLVYKIVHQRESVPDLYAQQLAKEQVLSESKAKEMRDEYMKY--LGEELALAPAY---------- 498
            ||:||.:|::..|...||.:|..|..::   .:|..:|..||  :.||     ||
Human   511 PLMYKQIHRQVPVLKKYADKLIAEGTVT---LQEFEEEIAKYDRICEE-----AYGRSKDKKILH 567

  Fly   499 ------QPPPSYFEKQWTNFQLAPSKELTYWDTGLDYSLLHYIGQQSVTFP-EDFNIHPHLLKTH 556
                  .|.|.:|     |....| |.:|...||:...:|.:||..:.:.| |||.||..|.:.
Human   568 IKHWLDSPWPGFF-----NVDGEP-KSMTCPATGIPEDMLTHIGSVASSVPLEDFKIHTGLSRI- 625

  Fly   557 VNARLKKLENGVKIDWSTAEALAIGSLMYQGHNVRISGEDVGRGTFSHRHAMLVDQQTN-EMFIP 620
            :..|....:|.. :||:.||.:|.|||:.:|.:||:||:||.||||||||.:|.||:.: ...:|
Human   626 LRGRADMTKNRT-VDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRRTCVP 689

  Fly   621 LNSMEGGNGGKLELAHSILSEEAVLGFEYGMAIDNPNNLIIWEAQFGDFANGAQIIIDTFIVSGE 685
            :|.: ..:.....:.:|.|||..|||||.|.|:.:||.|::||||||||.|.||.|||.||.:|:
Human   690 MNHL-WPDQAPYTVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFISTGQ 753

  Fly   686 TKWMESNALVMLLPHGYDGAASEHSSCRIERFLQLCDSKETSADGDS---------------VNV 735
            .||:..|.:|:|||||.:|...||||.|.|||||:     ::.|.|:               .|.
Human   754 AKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQM-----SNDDSDAYPAFTKDFEVSQLYDCNW 813

  Fly   736 HIVNPTTPAQYYHVLRRQLARNFRKPLVVVAPKTLLRLPAATSTHEDFQPGTLFHNVL---GDTI 797
            .:||.:|||.|:||||||:...|||||::..||:|||.|.|.|:.:....||.|..|:   |...
Human   814 IVVNCSTPANYFHVLRRQILLPFRKPLIIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIPEDGAAA 878

  Fly   798 AKPEQVRKVILCSGKHYYTLAEEREKRQAYD-TAILRLESLCPFPIQELQAQLAQYGNVQSFVWS 861
            ..||||:::|.|:||.||.|.:||..:...: .||.|||.:.|||...::.:..:|...: ..|.
Human   879 RAPEQVQRLIFCTGKVYYDLVKERSSQDLEEKVAITRLEQISPFPFDLIKQEAEKYPGAE-LAWC 942

  Fly   862 QEEHRNMGAWTFVRPRFENLI--GQQLHYCGRCEAPTPATGIGKVHKREVDEIVAAPFEL 919
            ||||:|||.:.::.|||..::  .:.:.|.||..|..||||....|...:.:.:...|.|
Human   943 QEEHKNMGYYDYISPRFMTILRRARPIWYVGRDPAAAPATGNRNTHLVSLKKFLDTAFNL 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1544	NP_651849.1	sucA	35..918	CDD:236499	336/948 (35%)
		TPP_E1_OGDC_like	178..449	CDD:238974	109/278 (39%)
		Transket_pyr	569..772	CDD:280874	102/218 (47%)
		OxoGdeHyase_C	779..917	CDD:293475	47/143 (33%)
OGDHL	NP_001334748.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100		5/11 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D134699at2759
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720