Protein Alignment CG1544 and OGDH

DIOPT Version :10

• Sequence 1: NP_651849.1
• Gene: CG1544 / 43689
• FlyBaseID: FBgn0039827
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: NP_001425936.1
• Gene: OGDH / 4967
• HGNCID: 8124
• Length: 1038
• Species: Homo sapiens
• Alignment Length: 984
• Identity: 339/984 - (34%)
• Similarity: 530/984 - (53%)
• Gaps: 122/984 - (12%)

  Fly    18 PQSRCYHSEKGVWGYKPIAQREFQVAEDVRASRNSQANVYRFVE----------AFRQHGHKLAA 72
            |....|.|.      .|:::.........::...:|.||.:.||          |::..||.:|.
Human    88 PPGTAYQSP------LPLSRGSLAAVAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQ 146

  Fly    73 VNPISIRTSQQELQELSPA-------------------------FYGLQTQE-------PVRTDG 105
            ::|:.|..:  :|....||                         ||||...:       |..|
Human   147 LDPLGILDA--DLDSSVPADIISSTDKLDLAVFKERLRMLTVGGFYGLDESDLDKVFHLPTTT-- 207

  Fly   106 LLSGPQVAHNVAQLEQLLKDIYCGRSTSAEFSYVEDIEEREWLARNFETLDQQQLGKSERCEIAE 170
            .:.|.:.|..:.::.:.|:..|| :....||.::.|:|:.:|:.:.|||....|....|:..:..
Human   208 FIGGQESALPLREIIRRLEMAYC-QHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLA 271

  Fly   171 LLIKSQAWDNFMALKFPTVKRYGGEGAESMLAFFWQLLRDSVQANIEHVVLAMPHRGRTPLQAAL 235
            .|::|..::.|:..|:.:.||:|.||.|.::.....::..|.:..:::|::.||||||..:.|.:
Human   272 RLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLNVLANV 336

  Fly   236 LNMRPAKVF----RKLSGASEFSEDIEAMSDVISHFHVS----EQLKILGKKLSFSMVRNPSHLE 292
            :.....::|    .||..|.|.|.|::        :|:.    ...::..:.::.|:|.||||||
Human   337 IRKELEQIFCQFDSKLEAADEGSGDVK--------YHLGMYHRRINRVTDRNITLSLVANPSHLE 393

  Fly   293 AANPVAMGKTRSKQQARGEGAFGDGSQPFGEHVLNVILHGDAAFAGQGINQECLNMAYVPHFEVG 357
            ||:||.||||:::|...|:..        |:.|::::||||||||||||..|..:::.:|.:...
Human   394 AADPVVMGKTKAEQFYCGDTE--------GKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTH 450

  Fly   358 GSLHLIVNNQVGFTTPGDRGRSTAYTSDLAKSIQAPVFHVNGDDPEALARVTSLAFRYQREFRKD 422
            |::|::||||:||||.....||:.|.:|:|:.:.||:||||.|||||:..|..:|..::..|.||
Human   451 GTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKD 515

  Fly   423 IFIDLNCFRRWGHNELDDPTFTNPLVYKIVHQRESVPDLYAQQLAKEQVLSESKAKEMRDEYMKY 487
            :.:||.|:||.||||:|:|.||.||:||.:.:::.|...||:.|..:.|:::.:.:|...:|.|.
Human   516 VVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKI 580

  Fly   488 LGEELALAPAYQ----------PPPSYFEKQWTNFQLAPSKELTYWDTGLDYSLLHYIGQQSVTF 542
            ..|..|.:...:          |.|.:|...      ...:.::...|||...:|.:||..:.:.
Human   581 CEEAFARSKDEKILHIKHWLDSPWPGFFTLD------GQPRSMSCPSTGLTEDILTHIGNVASSV 639

  Fly   543 P-EDFNIH---PHLLKTHVNARLKKLENGVKIDWSTAEALAIGSLMYQGHNVRISGEDVGRGTFS 603
            | |:|.||   ..:|||    |.:.::|.. :||:.||.:|.|||:.:|.::|:||:||.|||||
Human   640 PVENFTIHGGLSRILKT----RGEMVKNRT-VDWALAEYMAFGSLLKEGIHIRLSGQDVERGTFS 699

  Fly   604 HRHAMLVDQQTNE-MFIPLNSMEGGNGGKLELAHSILSEEAVLGFEYGMAIDNPNNLIIWEAQFG 667
            |||.:|.||..:: ..||:|.: ..|.....:.:|.|||..|||||.|.|:.:||.|::||||||
Human   700 HRHHVLHDQNVDKRTCIPMNHL-WPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFG 763

  Fly   668 DFANGAQIIIDTFIVSGETKWMESNALVMLLPHGYDGAASEHSSCRIERFLQLC--------DSK 724
            ||.|.||.|||.||..|:.||:..|.:|:|||||.:|...||||.|.|||||:|        |.|
Human   764 DFHNTAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLK 828

  Fly   725 ETSADGDSV---NVHIVNPTTPAQYYHVLRRQLARNFRKPLVVVAPKTLLRLPAATSTHEDFQPG 786
            |.:.|.:.:   |..:||.:||..::||||||:...|||||::..||:|||.|.|.|:.::..||
Human   829 EANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPG 893

  Fly   787 TLFHNVL---GDTIAKPEQVRKVILCSGKHYYTLAEEREKRQAY-DTAILRLESLCPFPIQELQA 847
            |.|..|:   |.....||.|::::.|:||.||.|..||:.|... ..||.|:|.|.|||...|..
Human   894 THFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLK 958

  Fly   848 QLAQYGNVQSFVWSQEEHRNMGAWTFVRPRFENLI--GQQLHYCGRCEAPTPATGIGKVHKREVD 910
            ::.:|.|.: ..|.||||:|.|.:.:|:||....|  .:.:.|.||..|..||||..|.|..|:.
Human   959 EVQKYPNAE-LAWCQEEHKNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQ 1022

  Fly   911 EIVAAPFEL 919
            .::...|:|
Human  1023 RLLDTAFDL 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1544	NP_651849.1	SucA	36..919	CDD:440333	334/964 (35%)
OGDH	NP_001425936.1	None