DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1544 and OGDH

DIOPT Version :9

Sequence 1:	NP_651849.1	Gene:	CG1544 / 43689	FlyBaseID:	FBgn0039827	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	XP_005249816.1	Gene:	OGDH / 4967	HGNCID:	8124	Length:	1038	Species:	Homo sapiens

Alignment Length:	984	Identity:	339/984 - (34%)
Similarity:	530/984 - (53%)	Gaps:	122/984 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PQSRCYHSEKGVWGYKPIAQREFQVAEDVRASRNSQANVYRFVE----------AFRQHGHKLAA 72
            |....|.|.      .|:::.........::...:|.||.:.||          |::..||.:|.
Human    88 PPGTAYQSP------LPLSRGSLAAVAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQ 146

  Fly    73 VNPISIRTSQQELQELSPA-------------------------FYGLQTQE-------PVRTDG 105
            ::|:.|..:  :|....||                         ||||...:       |..|
Human   147 LDPLGILDA--DLDSSVPADIISSTDKLDLAVFKERLRMLTVGGFYGLDESDLDKVFHLPTTT-- 207

  Fly   106 LLSGPQVAHNVAQLEQLLKDIYCGRSTSAEFSYVEDIEEREWLARNFETLDQQQLGKSERCEIAE 170
            .:.|.:.|..:.::.:.|:..|| :....||.::.|:|:.:|:.:.|||....|....|:..:..
Human   208 FIGGQESALPLREIIRRLEMAYC-QHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLA 271

  Fly   171 LLIKSQAWDNFMALKFPTVKRYGGEGAESMLAFFWQLLRDSVQANIEHVVLAMPHRGRTPLQAAL 235
            .|::|..::.|:..|:.:.||:|.||.|.::.....::..|.:..:::|::.||||||..:.|.:
Human   272 RLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLNVLANV 336

  Fly   236 LNMRPAKVF----RKLSGASEFSEDIEAMSDVISHFHVS----EQLKILGKKLSFSMVRNPSHLE 292
            :.....::|    .||..|.|.|.|::        :|:.    ...::..:.::.|:|.||||||
Human   337 IRKELEQIFCQFDSKLEAADEGSGDVK--------YHLGMYHRRINRVTDRNITLSLVANPSHLE 393

  Fly   293 AANPVAMGKTRSKQQARGEGAFGDGSQPFGEHVLNVILHGDAAFAGQGINQECLNMAYVPHFEVG 357
            ||:||.||||:::|...|:..        |:.|::::||||||||||||..|..:::.:|.:...
Human   394 AADPVVMGKTKAEQFYCGDTE--------GKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTH 450

  Fly   358 GSLHLIVNNQVGFTTPGDRGRSTAYTSDLAKSIQAPVFHVNGDDPEALARVTSLAFRYQREFRKD 422
            |::|::||||:||||.....||:.|.:|:|:.:.||:||||.|||||:..|..:|..::..|.||
Human   451 GTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKD 515

  Fly   423 IFIDLNCFRRWGHNELDDPTFTNPLVYKIVHQRESVPDLYAQQLAKEQVLSESKAKEMRDEYMKY 487
            :.:||.|:||.||||:|:|.||.||:||.:.:::.|...||:.|..:.|:::.:.:|...:|.|.
Human   516 VVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKI 580

  Fly   488 LGEELALAPAYQ----------PPPSYFEKQWTNFQLAPSKELTYWDTGLDYSLLHYIGQQSVTF 542
            ..|..|.:...:          |.|.:|...      ...:.::...|||...:|.:||..:.:.
Human   581 CEEAFARSKDEKILHIKHWLDSPWPGFFTLD------GQPRSMSCPSTGLTEDILTHIGNVASSV 639

  Fly   543 P-EDFNIH---PHLLKTHVNARLKKLENGVKIDWSTAEALAIGSLMYQGHNVRISGEDVGRGTFS 603
            | |:|.||   ..:|||    |.:.::|.. :||:.||.:|.|||:.:|.::|:||:||.|||||
Human   640 PVENFTIHGGLSRILKT----RGEMVKNRT-VDWALAEYMAFGSLLKEGIHIRLSGQDVERGTFS 699

  Fly   604 HRHAMLVDQQTNE-MFIPLNSMEGGNGGKLELAHSILSEEAVLGFEYGMAIDNPNNLIIWEAQFG 667
            |||.:|.||..:: ..||:|.: ..|.....:.:|.|||..|||||.|.|:.:||.|::||||||
Human   700 HRHHVLHDQNVDKRTCIPMNHL-WPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFG 763

  Fly   668 DFANGAQIIIDTFIVSGETKWMESNALVMLLPHGYDGAASEHSSCRIERFLQLC--------DSK 724
            ||.|.||.|||.||..|:.||:..|.:|:|||||.:|...||||.|.|||||:|        |.|
Human   764 DFHNTAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLK 828

  Fly   725 ETSADGDSV---NVHIVNPTTPAQYYHVLRRQLARNFRKPLVVVAPKTLLRLPAATSTHEDFQPG 786
            |.:.|.:.:   |..:||.:||..::||||||:...|||||::..||:|||.|.|.|:.::..||
Human   829 EANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPG 893

  Fly   787 TLFHNVL---GDTIAKPEQVRKVILCSGKHYYTLAEEREKRQAY-DTAILRLESLCPFPIQELQA 847
            |.|..|:   |.....||.|::::.|:||.||.|..||:.|... ..||.|:|.|.|||...|..
Human   894 THFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLK 958

  Fly   848 QLAQYGNVQSFVWSQEEHRNMGAWTFVRPRFENLI--GQQLHYCGRCEAPTPATGIGKVHKREVD 910
            ::.:|.|.: ..|.||||:|.|.:.:|:||....|  .:.:.|.||..|..||||..|.|..|:.
Human   959 EVQKYPNAE-LAWCQEEHKNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQ 1022

  Fly   911 EIVAAPFEL 919
            .::...|:|
Human  1023 RLLDTAFDL 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1544	NP_651849.1	sucA	35..918	CDD:236499	333/964 (35%)
		TPP_E1_OGDC_like	178..449	CDD:238974	105/278 (38%)
		Transket_pyr	569..772	CDD:280874	104/214 (49%)
		OxoGdeHyase_C	779..917	CDD:293475	51/143 (36%)
OGDH	XP_005249816.1	sucA	49..1030	CDD:236499	337/981 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D134699at2759
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720