DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1544 and dhtkd1

DIOPT Version :9

Sequence 1:	NP_651849.1	Gene:	CG1544 / 43689	FlyBaseID:	FBgn0039827	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_001008619.1	Gene:	dhtkd1 / 494076	ZFINID:	ZDB-GENE-041212-44	Length:	925	Species:	Danio rerio

Alignment Length:	904	Identity:	446/904 - (49%)
Similarity:	602/904 - (66%)	Gaps:	17/904 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YHSEKGVWGYKPIAQREFQVAEDVRASRNSQANVYRFVEAFRQHGHKLAAVNPI----SIRTSQQ 83
            ||:::||:|::|....|.:......::.|....:.|.|||:|.||||:|.:||:    .:..|..
Zfish    29 YHTQRGVYGFRPRDGPERRAELTQISALNRDHGLARLVEAYRAHGHKVAKINPLLPQSPVLESVP 93

  Fly    84 ELQELSPAFYGLQTQEPVRTDGLLSGPQVAHNVAQLEQLLKDIYCGRSTSAEFSYVEDIEEREWL 148
            |:..|:.|..|:     :.|.||....:......::...|:..||| ..|.|.|.::.:|||||.
Zfish    94 EISLLNGAVRGV-----LNTTGLRHFGKAEATAEEVVAYLESTYCG-GISVETSQLQTLEEREWF 152

  Fly   149 ARNFETLDQQQLGKSERCEIAELLIKSQAWDNFMALKFPTVKRYGGEGAESMLAFFWQLLRDSVQ 213
            |..||.|.::.....||..:|:|:::||.:|:|:|.||.|||||||||||||:.||::|.|.||.
Zfish   153 ADRFEELKKEAFSPEERRMLAKLMLESQEFDHFLATKFATVKRYGGEGAESMMGFFYELFRSSVY 217

  Fly   214 ANIEHVVLAMPHRGRTPLQAALLNMRPAKVFRKLSGASEFSEDIEAMSDVISHFHVSEQLKI-LG 277
            :.:..||:.||||||..|...||...|..:|||:.|.|||.|...::.||:||...:.:|.. .|
Zfish   218 SGVTDVVMGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPEHSPSIGDVLSHLTSTVELDFGAG 282

  Fly   278 KKLSFSMVRNPSHLEAANPVAMGKTRSKQQARGEGAFGDG--SQPFGEHVLNVILHGDAAFAGQG 340
            ..|..:|:.|||||||.|||..||||.:||.:.:|.:...  |:| |:.|:.:.:||||:|:|||
Zfish   283 HPLHVTMLPNPSHLEAINPVTQGKTRGRQQVKQDGDYSTDPHSRP-GDKVICLQVHGDASFSGQG 346

  Fly   341 INQECLNMAYVPHFEVGGSLHLIVNNQVGFTTPGDRGRSTAYTSDLAKSIQAPVFHVNGDDPEAL 405
            |..|...::.:||:.||||:|||||||||:|||.:||||:.|.||:.|.:...:.||||||.|.:
Zfish   347 IVPETFTLSNLPHYRVGGSIHLIVNNQVGYTTPSERGRSSLYCSDVGKMVGCAIIHVNGDDAEEV 411

  Fly   406 ARVTSLAFRYQREFRKDIFIDLNCFRRWGHNELDDPTFTNPLVYKIVHQRESVPDLYAQQLAKEQ 470
            .|.|.||..|||.||||:.:||.|:|:|||||||:|.||||.:|||:..|:|:||.||.||..|.
Zfish   412 LRATRLAVEYQRRFRKDVIVDLLCYRQWGHNELDEPFFTNPAMYKIIRSRKSIPDSYADQLISEG 476

  Fly   471 VLSESKAKEMRDEYMKYLGEELALAPAYQPPPSYFEKQWTNFQLAPSKELTYWDTGLDYSLLHYI 535
            ::::.:..:::..|...|..:|.....|.|||:..:.:|.:. :.|...::.||||:...||.::
Zfish   477 LMTDEERSQIKTSYYATLNNQLTNMTLYSPPPTNLQGRWGDL-VEPQNRVSCWDTGVAQPLLQFV 540

  Fly   536 GQQSVTFPEDFNIHPHLLKTHVNARLKKLENGVKIDWSTAEALAIGSLMYQGHNVRISGEDVGRG 600
            |.:||..||:..:|.||.||||.|||:|||.|.|:|||||||||.|:|:.||.|:||||:|||||
Zfish   541 GAKSVDIPEEIILHSHLRKTHVQARLQKLEEGTKLDWSTAEALAFGTLLCQGFNIRISGQDVGRG 605

  Fly   601 TFSHRHAMLVDQQTNEMFIPLNSMEGGNGGKLELAHSILSEEAVLGFEYGMAIDNPNNLIIWEAQ 665
            |||.||||:|.|:||:||||||.:.....|.||:.:|.|||||||||||||:|..|..|.|||||
Zfish   606 TFSQRHAMVVCQETNDMFIPLNHISSEQKGHLEVCNSALSEEAVLGFEYGMSIAQPRLLPIWEAQ 670

  Fly   666 FGDFANGAQIIIDTFIVSGETKWMESNALVMLLPHGYDGAASEHSSCRIERFLQLCDSKETSADG 730
            ||||.||||||.|||:..||.||:..:.||:|||||||||..||||||||||||||||||...||
Zfish   671 FGDFFNGAQIIFDTFLSGGEAKWLLQSGLVILLPHGYDGAGPEHSSCRIERFLQLCDSKEEGVDG 735

  Fly   731 DSVNVHIVNPTTPAQYYHVLRRQLARNFRKPLVVVAPKTLLRLPAATSTHEDFQPGTLFHNVLGD 795
            |:||:.:||||.||||:|:||||:.|||||||:|.:||||||...|.|...|..|||.|..::||
Zfish   736 DTVNMAVVNPTLPAQYFHLLRRQMIRNFRKPLIVASPKTLLRFSGAVSGLSDMGPGTSFKPIIGD 800

  Fly   796 TIAKPEQVRKVILCSGKHYYTLAEERE--KRQAYDTAILRLESLCPFPIQELQAQLAQYGNVQSF 858
            :...|..|::|:.|||||||.|.:.||  .....:||::|:|.|||||.:.||.:|.:|.|.:.|
Zfish   801 SSVNPASVQRVLFCSGKHYYALLKHRETIPEAEKNTALVRVEELCPFPTEALQQELNKYTNAKEF 865

  Fly   859 VWSQEEHRNMGAWTFVRPRFENLIGQQLHYCGRCEAPTPATGIGKVHKREVDEIVAAPF 917
            :|||||.:|||.|:||.||||..:..:|....|...|.||.|||.:|.::.:.|:.:.|
Zfish   866 IWSQEEPQNMGCWSFVSPRFEKQLACKLRLVSRPALPAPAVGIGTLHHQQHEAILTSSF 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1544	NP_651849.1	sucA	35..918	CDD:236499	440/892 (49%)
		TPP_E1_OGDC_like	178..449	CDD:238974	143/273 (52%)
		Transket_pyr	569..772	CDD:280874	142/202 (70%)
		OxoGdeHyase_C	779..917	CDD:293475	60/139 (43%)
dhtkd1	NP_001008619.1	sucA	43..925	CDD:236499	440/890 (49%)
		TPP_E1_OGDC_like	182..455	CDD:238974	143/273 (52%)
		Transket_pyr	574..777	CDD:280874	142/202 (70%)
		OxoGdeHyase_C	785..924	CDD:293475	60/138 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574858
Domainoid	1	1.000	303	1.000	Domainoid score	I1365
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10278
Inparanoid	1	1.050	893	1.000	Inparanoid score	I371
OMA	1	1.010	-	-		QHG55056
OrthoDB	1	1.010	-	-		D134699at2759
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	1	1.000	-	-		oto41353
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	1	1.100	-	-	LDO	PTHR23152
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5554
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770