DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mesh and SUSD2

DIOPT Version :9

Sequence 1:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster
Sequence 2:	NP_062547.1	Gene:	SUSD2 / 56241	HGNCID:	30667	Length:	822	Species:	Homo sapiens

Alignment Length:	820	Identity:	246/820 - (30%)
Similarity:	362/820 - (44%)	Gaps:	129/820 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 IGSCNKDIDAALLPLTFAPESGNMLGGQVVNITGPCFDPAIR-----------VTCHF-DTESVL 480
            :|:|..|.....|.:  .|.||:|:||:         |..:|           |.|.| |:...|
Human    51 LGTCCLDFRDFCLEI--LPYSGSMMGGK---------DFVVRHFKMSSPTDASVICRFKDSIQTL 104

  Fly   481 GTYVDRNRVICVQPYLKAEGYIRFQISVGT-QRFKWRGKYFVETPAAATEKIFFTTDDVHKKNPA 544
            |......:|.||.|.|...|.|.|.:|:.. ..|...|.:....|    .|:     .:.:|:..
Human   105 GHVDSSGQVHCVSPLLYESGRIPFTVSLDNGHSFPRAGTWLAVHP----NKV-----SMMEKSEL 160

  Fly   545 EIRITWNQYNLTSNANAN--------------VMISLWGYRETKIEPQLE------YIDVIEASY 589
            .....| ||..|:|.:.|              :.|.||||.||.:....|      |:..:....
Human   161 VNETRW-QYYGTANTSGNLSLTWHVKSLPTQTITIELWGYEETGMPYSQEWTAKWSYLYPLATHI 224

  Fly   590 SNSGSYVITPS----NYINRNNINRDMQFGFLQINLTQPDQYSGLAISPVLWSRPIPLAWYMAPQ 650
            .||||:..||.    :|       :..:.|.|:|  .....|:|......||:....|||:::..
Human   225 PNSGSFTFTPKPAPPSY-------QRWRVGALRI--IDSKNYAGQKDVQALWTNDHALAWHLSDD 280

  Fly   651 WERQHGKRWARALCDNWIRADRFLRNFAADLPLCPCTLDQAVLDKGRFRPDRECDKDSNPSCLRH 715
            : |:....|||..|..|...:..|.||..:||.|||||.||..|.|||..|..||.:....|..|
Human   281 F-REDPVAWARTQCQAWEELEDQLPNFLEELPDCPCTLTQARADSGRFFTDYGCDMEQGSVCTYH 344

  Fly   716 RGAIHCVVS-GTPVAQGAEQQCCYDRYGFLMLTYDQMWGSRPRRVHNLGKMPWNEASKVPSLSMW 779
            .||:|||.| ...:..|:.|||||...|..:||.|...||.|.|.|:.|..|:....:|||:|.|
Human   345 PGAVHCVRSVQASLRYGSGQQCCYTADGTQLLTADSSGGSTPDRGHDWGAPPFRTPPRVPSMSHW 409

  Fly   780 FHDMRPFYSCCYWQEEQAVGCETYRFERRPSQDCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLG 844
            .:|:..||.||.|    |..|..| .:||||.||..|:.|.:|..||||||||||||.:||||.|
Human   410 LYDVLSFYYCCLW----APDCPRY-MQRRPSNDCRNYRPPRLASAFGDPHFVTFDGTNFTFNGRG 469

  Fly   845 EFVLARSVDESNKFEVQGRFEQLPVNYYGEVKATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLD 909
            |:||..:.  .....||.|.:...::...|.:.|.|||||::...:..:||||    |.....|:
Human   470 EYVLLEAA--LTDLRVQARAQPGTMSNGTETRGTGLTAVAVQEGNSDVVEVRL----ANRTGGLE 528

  Fly   910 VLADGRRVYFDRESLKFQHFDGVTVYTPTYLLNQSQVVVQFDAGIGVEVVENEGYMTGRVFLPWK 974
            ||.:...:.|..:|  :....|:.:....    ..:|.:...:|.|:||.....:::..|.||.|
Human   529 VLLNQEVLSFTEQS--WMDLKGMFLSVAA----GDRVSIMLASGAGLEVSVQGPFLSVSVLLPEK 587

  Fly   975 FINKTAGLFGNWSFNKLDDFMLPNGQV-------AQLNLNDLRSIHTNFGIKWMLTDREVPGVGA 1032
            |:..|.||.|..:.:..|||.|.:|:|       .:|.|         ||..|.:.:      .:
Human   588 FLTHTHGLLGTLNNDPTDDFTLHSGRVLPPGTSPQELFL---------FGANWTVHN------AS 637

  Fly  1033 ALFKREFGRMSGYYA-NATFQPNYVLDPA--DFLPANRSYDLERAEE---LCGECMQCQYDYAMT 1091
            :|...:    |.:.. |..:||.:  ||.  ...|:..:.:...|:|   |||:...|.:|.|.|
Human   638 SLLTYD----SWFLVHNFLYQPKH--DPTFEPLFPSETTLNPSLAQEAAKLCGDDHFCNFDVAAT 696

  Fly  1092 LNRDLAHFTKNYYDTIVNMQAENAVRVVSCGVLQTPRFGRKLSFDFMPGAKVSFECNEGFILIGD 1156
            .:......|:..:. :...:.::...|||||.|..|..|:|....::.|:.:.|.|:.|:.|.|.
Human   697 GSLSTGTATRVAHQ-LHQRRMQSLQPVVSCGWLAPPPNGQKEGNRYLAGSTIYFHCDNGYSLAGA 760

  Fly  1157 QRRECLSNGLWNIPEYGYTECLREVYYTRRVAFIAIGIIF 1196
            :...|.::|.|:.|.   .:|.....|.     :.:||||
Human   761 ETSTCQADGTWSSPT---PKCQPGRSYA-----VLLGIIF 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712
		AMOP	660..805	CDD:281737	62/145 (43%)
		VWD	811..999	CDD:214566	64/187 (34%)
		CCP	1121..1171	CDD:214478	15/49 (31%)
SUSD2	NP_062547.1	Somatomedin_B	29..64	CDD:279385	3/12 (25%)
		GPI-anchored	180..256	CDD:287331	19/84 (23%)
		AMOP	289..430	CDD:281737	62/145 (43%)
		VWD	448..613	CDD:295339	59/176 (34%)
		CCP	725..779	CDD:153056	16/56 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141672
Domainoid	1	1.000	118	1.000	Domainoid score	I5886
eggNOG	1	0.900	-	-		E1_KOG4291
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10481
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2749
Isobase	1	0.950	-	0	Normalized mean entropy	S7078
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296951at33208
OrthoFinder	1	1.000	-	-		FOG0007412
OrthoInspector	1	1.000	-	-		oto89286
orthoMCL	1	0.900	-	-		OOG6_107727
Panther	1	1.100	-	-	O	PTHR13802
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2922
SonicParanoid	1	1.000	-	-		X5542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740