Protein Alignment mesh and tecta

DIOPT Version :10

• Sequence 1: NP_001163782.1
• Gene: mesh / 43688
• FlyBaseID: FBgn0051004
• Length: 1454
• Species: Drosophila melanogaster
• Sequence 2: XP_009300199.1
• Gene: tecta / 561355
• ZFINID: ZDB-GENE-110411-120
• Length: 2201
• Species: Danio rerio
• Alignment Length: 1261
• Identity: 254/1261 - (20%)
• Similarity: 399/1261 - (31%)
• Gaps: 452/1261 - (35%)

  Fly   200 LPFYGFRFNYTRLSL--NGYLEFSDPPEYLTYPLVFPIKDWPAKRDPSFMGIFFSKCRVGRIYPS 262
            :||..|...|..|.:  ||.:.|:......| |..||:.|              |:..:..:: :
Zfish    55 IPFIFFNVPYRSLYVNNNGVISFNIQVSQFT-PEAFPLSD--------------SRSFIAPLW-A 103

  Fly   263 DIDQRTPG-VYFRVERDLMGRTDRFGVEVRERTMWDIRQGVVGADTFIPKHVVIATWKNVSFAGG 326
            |:.....| ||:|...|         .|:.||...|:|:......:|....|.|.||..|:|.||
Zfish   104 DVHNGIRGDVYYRESTD---------TEILERATQDVRKYFKNMVSFTATWVFITTWNQVTFYGG 159

  Fly   327 IDNSLYTTNTFQMVLATDEVYTYIIFNYAVLNWLSHTEAGGDTTKGEGGVPAYVGFNAGNGTQAY 391
            ...:  ..||||.||.:|....:.:|||..::|.:.|.:|||...|.||..|..|||.|:.:..:
Zfish   160 SQTT--PVNTFQAVLISDGHAYFSMFNYGEIHWSTGTASGGDPLTGLGGTTAQAGFNGGDVSHFF 222

  Fly   392 EYNPYSQNMVIRDLANRGWANGFPGRHIFRVDEQILIGSCNKDIDAALLPLTFAPESG-NMLG-- 453
            .. |.|::..:.::......| .|||..||:|..        .||         |.:| :.:|
Zfish   223 NL-PGSRSNEVVNIEQTTNVN-VPGRWFFRIDAD--------QID---------PANGCSYIGRF 268

  Fly   454 ---GQVVNITGP------CFDPAIRVTCH------FDT-ESVLGTYV--DRNRVICV---QP-YL 496
               |:|..::..      |.|....|.||      .:| |.|.|.|.  ......||   .| |.
Zfish   269 YRRGEVFWLSDQCTQRCRCLDLDNEVICHETPCGQLETCEQVEGAYYCQPTRTSTCVVFGDPHYH 333

  Fly   497 KAEGYIRFQISVGTQRFKWRGKYFVETPAAATEKIFFTTDDVHKKNPAEIRITWNQYNLTSNANA 561
            ..:|::        ..|:....|.:..|......:.|.:.:...:|.....::|.:
Zfish   334 TFDGFL--------YHFQGTCSYLLARPCWEMPGLPFFSVEAKNENRGVPTVSWLR--------- 381

  Fly   562 NVMISLWGYRET------------------KIEPQLEYIDV--------IEASYSNSGSY----- 595
            :|.:.::.:|.|                  .::.||..:.|        :|..:....:|
Zfish   382 DVTVEVYNHRVTLPKGTLGTVQVDGLIKTLPVQLQLGAVKVYQSGVAVALETDFGLLVTYDGLHY 446

  Fly   596 --VITPSNYINR-----NNINRDMQFGFLQINLTQPDQYSGLAISPVLWSRPIPLAWYMAPQWER 653
              :..||:|.|.     .|.|.|.     ..:...||  ..||.|.|          .:...|..
Zfish   447 ASISLPSSYFNNTCGLCGNYNDDP-----ADDPVLPD--GSLAESVV----------ELGGSWRA 494

  Fly   654 Q-------HGKRWARALCDNWIRADRFLRNFA-----ADLPLCPCTLDQAVLDKGRF-------- 698
            :       .|.....::|:....|..|..::.     .|.|...|   :||:|...|
Zfish   495 EDTDFRCTDGCAQNCSMCEPAAEAFYFRSDYCGLINKTDGPFRDC---RAVVDPTAFVYSCVYDM 556

  Fly   699 ----------------------------RPDRE-------CDKDSN---------PSCLRHRGAI 719
                                        ||.|.       |.::|:         .||......:
Zfish   557 CSNRDNITTLCQAIQAYALACQALGVTIRPWRSRSFCALTCPENSHYQVCTSACPASCSDLTSHL 621

  Fly   720 HC--------------VVSGTPVAQGAEQQCCYDRYGFLMLTYDQMWGSRPRRVHN--LGKMPWN 768
            :|              |:||:...:..|  |..:|.|......:..|......|..  ..:....
Zfish   622 YCAHPCTEGCQCDQGYVLSGSRCVRRFE--CGCERDGLYYALNETFWAGEGGEVGEDCSQRCVCG 684

  Fly   769 EASKVPSLSMWFHDMRPFYSC-----CYWQEEQAVGCETYRFERRPSQDCVAYQAPGIAGVFGDP 828
            .|.:|..    |:|     ||     |. .|...:||    :.||.: .|...|:..:|
Zfish   685 PAGEVKC----FND-----SCGEGEVCA-AEVGLLGC----YPRREA-ICSLSQSQILA------ 728

  Fly   829 HFVTFDGTAYTFNGLGEFVLARSVDESNKFEVQGRFEQLPVNYYGEVKATQLTAVAMRGNTTTTI 893
               ||||:...|.....|.|.:::         ||   ||.|                   .|::
Zfish   729 ---TFDGSTMPFPDESSFYLVKTL---------GR---LPAN-------------------VTSV 759

  Fly   894 EVR------------LRPLHARWRYRLDVLADGRRVYFDRESLKFQHFDGVTVYTPTYLLNQSQV 946
            ||:            |||:..|..: |:....|.    |.:.:|   .:|.....| |:.....:
Zfish   760 EVKIGRKLVNKGPTWLRPVVVRVGH-LEAQIGGS----DFDLIK---VNGEPAIVP-YVHPVEPL 815

  Fly   947 VVQFDAGIGVEVVENEGYMTGR--------VFLPWKFINKTAGLFGNWSFNKLDDFMLPNGQVA- 1002
            ::...:| ...|:|..|.:..|        :.|...|.|.|.||.|.::.:.:||..||:|:.|
Zfish   816 MIYRSSG-NTTVIEWSGLVRTRYSRQGLLNITLSTLFYNTTCGLCGFFNGDPIDDLRLPSGRQAD 879

  Fly  1003 --------------QLNLN-----------DLRSIHTNFGIKWMLTDREVPGVGAAL-------- 1034
                          .|..|           |||...:    .|:..:...||..:.|
Zfish   880 SADQFIESWRAIADDLTCNGDCEDLYRMCTDLRQYQS----PWLCGNINDPGNSSFLACHTAVNP 940

  Fly  1035 ---FK--------REFGRMS-------------------GYYANATFQPNYVLDPADFLPANRSY 1069
               |:        ||..|.:                   |.:.:||..|.    |.   |.|..:
Zfish   941 SPFFRNCLYNMCVREGNRSALCNSLQAYASACQDAQINLGTWRSATNCPL----PC---PENSHF 998

  Fly  1070 D------------LERAEE----LCGECMQCQYDYAMTLNRDLAHFTKNYYDTIVNMQAENAVRV 1118
            |            |:..||    .|.|..||:..:|:.             |.|...:::
Zfish   999 DECTSACPLTCSNLDEPEEPCPLPCSEGCQCEEGFALR-------------DGICVARSD----- 1045

  Fly  1119 VSCGVLQTPRFGRKLSFDFMPGAKVSFECNEGFILIGDQRRECLSNGLWNIPEYGYTECLREVYY 1183
              ||...   .||:|:            .||.|....:.:..|..||..|.....::.|..|.|.
Zfish  1046 --CGCFY---LGRQLA------------TNETFWTDWECQERCFCNGTDNSVYCTFSPCHPEEYC 1093

  Fly  1184 TRRVAFIAIGIIFLVICPLMLCIVCG 1209
            ....     |:.|.......:|.|.|
Zfish  1094 QENE-----GLFFCQPRTEAMCAVAG 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	49/160 (31%)
		TIG	446..511	CDD:460355	20/89 (22%)
		AMOP	660..803	CDD:461048	37/220 (17%)
		VWD	811..999	CDD:214566	45/207 (22%)
		CCP	1121..1171	CDD:214478	12/49 (24%)
tecta	XP_009300199.1	NIDO	100..256	CDD:214712	52/177 (29%)
		VWD	324..480	CDD:459671	28/179 (16%)
		C8	519..594	CDD:214843	11/77 (14%)
		TIL	597..650	CDD:410995	9/54 (17%)
		VWD	717..875	CDD:214566	45/208 (22%)
		C8	913..989	CDD:214843	11/79 (14%)
		TIL	992..1046	CDD:410995	13/76 (17%)
		VWD	1102..1265	CDD:214566	3/13 (23%)
		C8	1346..1420	CDD:214843
		TIL	1424..1477	CDD:410995
		VWC	1479..1532	CDD:450195
		VWD	1539..1690	CDD:459671
		C8	1732..1803	CDD:214843
		Zona_pellucida	1851..2102	CDD:459673
		FXa_inhibition	2132..2166	CDD:464251