DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mesh and tecta

DIOPT Version :9

Sequence 1:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster
Sequence 2:	XP_009300199.1	Gene:	tecta / 561355	ZFINID:	ZDB-GENE-110411-120	Length:	2201	Species:	Danio rerio

Alignment Length:	1261	Identity:	254/1261 - (20%)
Similarity:	399/1261 - (31%)	Gaps:	452/1261 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 LPFYGFRFNYTRLSL--NGYLEFSDPPEYLTYPLVFPIKDWPAKRDPSFMGIFFSKCRVGRIYPS 262
            :||..|...|..|.:  ||.:.|:......| |..||:.|              |:..:..:: :
Zfish    55 IPFIFFNVPYRSLYVNNNGVISFNIQVSQFT-PEAFPLSD--------------SRSFIAPLW-A 103

  Fly   263 DIDQRTPG-VYFRVERDLMGRTDRFGVEVRERTMWDIRQGVVGADTFIPKHVVIATWKNVSFAGG 326
            |:.....| ||:|...|         .|:.||...|:|:......:|....|.|.||..|:|.||
Zfish   104 DVHNGIRGDVYYRESTD---------TEILERATQDVRKYFKNMVSFTATWVFITTWNQVTFYGG 159

  Fly   327 IDNSLYTTNTFQMVLATDEVYTYIIFNYAVLNWLSHTEAGGDTTKGEGGVPAYVGFNAGNGTQAY 391
            ...:  ..||||.||.:|....:.:|||..::|.:.|.:|||...|.||..|..|||.|:.:..:
Zfish   160 SQTT--PVNTFQAVLISDGHAYFSMFNYGEIHWSTGTASGGDPLTGLGGTTAQAGFNGGDVSHFF 222

  Fly   392 EYNPYSQNMVIRDLANRGWANGFPGRHIFRVDEQILIGSCNKDIDAALLPLTFAPESG-NMLG-- 453
            .. |.|::..:.::......| .|||..||:|..        .||         |.:| :.:|
Zfish   223 NL-PGSRSNEVVNIEQTTNVN-VPGRWFFRIDAD--------QID---------PANGCSYIGRF 268

  Fly   454 ---GQVVNITGP------CFDPAIRVTCH------FDT-ESVLGTYV--DRNRVICV---QP-YL 496
               |:|..::..      |.|....|.||      .:| |.|.|.|.  ......||   .| |.
Zfish   269 YRRGEVFWLSDQCTQRCRCLDLDNEVICHETPCGQLETCEQVEGAYYCQPTRTSTCVVFGDPHYH 333

  Fly   497 KAEGYIRFQISVGTQRFKWRGKYFVETPAAATEKIFFTTDDVHKKNPAEIRITWNQYNLTSNANA 561
            ..:|::        ..|:....|.:..|......:.|.:.:...:|.....::|.:
Zfish   334 TFDGFL--------YHFQGTCSYLLARPCWEMPGLPFFSVEAKNENRGVPTVSWLR--------- 381

  Fly   562 NVMISLWGYRET------------------KIEPQLEYIDV--------IEASYSNSGSY----- 595
            :|.:.::.:|.|                  .::.||..:.|        :|..:....:|
Zfish   382 DVTVEVYNHRVTLPKGTLGTVQVDGLIKTLPVQLQLGAVKVYQSGVAVALETDFGLLVTYDGLHY 446

  Fly   596 --VITPSNYINR-----NNINRDMQFGFLQINLTQPDQYSGLAISPVLWSRPIPLAWYMAPQWER 653
              :..||:|.|.     .|.|.|.     ..:...||  ..||.|.|          .:...|..
Zfish   447 ASISLPSSYFNNTCGLCGNYNDDP-----ADDPVLPD--GSLAESVV----------ELGGSWRA 494

  Fly   654 Q-------HGKRWARALCDNWIRADRFLRNFA-----ADLPLCPCTLDQAVLDKGRF-------- 698
            :       .|.....::|:....|..|..::.     .|.|...|   :||:|...|
Zfish   495 EDTDFRCTDGCAQNCSMCEPAAEAFYFRSDYCGLINKTDGPFRDC---RAVVDPTAFVYSCVYDM 556

  Fly   699 ----------------------------RPDRE-------CDKDSN---------PSCLRHRGAI 719
                                        ||.|.       |.::|:         .||......:
Zfish   557 CSNRDNITTLCQAIQAYALACQALGVTIRPWRSRSFCALTCPENSHYQVCTSACPASCSDLTSHL 621

  Fly   720 HC--------------VVSGTPVAQGAEQQCCYDRYGFLMLTYDQMWGSRPRRVHN--LGKMPWN 768
            :|              |:||:...:..|  |..:|.|......:..|......|..  ..:....
Zfish   622 YCAHPCTEGCQCDQGYVLSGSRCVRRFE--CGCERDGLYYALNETFWAGEGGEVGEDCSQRCVCG 684

  Fly   769 EASKVPSLSMWFHDMRPFYSC-----CYWQEEQAVGCETYRFERRPSQDCVAYQAPGIAGVFGDP 828
            .|.:|..    |:|     ||     |. .|...:||    :.||.: .|...|:..:|
Zfish   685 PAGEVKC----FND-----SCGEGEVCA-AEVGLLGC----YPRREA-ICSLSQSQILA------ 728

  Fly   829 HFVTFDGTAYTFNGLGEFVLARSVDESNKFEVQGRFEQLPVNYYGEVKATQLTAVAMRGNTTTTI 893
               ||||:...|.....|.|.:::         ||   ||.|                   .|::
Zfish   729 ---TFDGSTMPFPDESSFYLVKTL---------GR---LPAN-------------------VTSV 759

  Fly   894 EVR------------LRPLHARWRYRLDVLADGRRVYFDRESLKFQHFDGVTVYTPTYLLNQSQV 946
            ||:            |||:..|..: |:....|.    |.:.:|   .:|.....| |:.....:
Zfish   760 EVKIGRKLVNKGPTWLRPVVVRVGH-LEAQIGGS----DFDLIK---VNGEPAIVP-YVHPVEPL 815

  Fly   947 VVQFDAGIGVEVVENEGYMTGR--------VFLPWKFINKTAGLFGNWSFNKLDDFMLPNGQVA- 1002
            ::...:| ...|:|..|.:..|        :.|...|.|.|.||.|.::.:.:||..||:|:.|
Zfish   816 MIYRSSG-NTTVIEWSGLVRTRYSRQGLLNITLSTLFYNTTCGLCGFFNGDPIDDLRLPSGRQAD 879

  Fly  1003 --------------QLNLN-----------DLRSIHTNFGIKWMLTDREVPGVGAAL-------- 1034
                          .|..|           |||...:    .|:..:...||..:.|
Zfish   880 SADQFIESWRAIADDLTCNGDCEDLYRMCTDLRQYQS----PWLCGNINDPGNSSFLACHTAVNP 940

  Fly  1035 ---FK--------REFGRMS-------------------GYYANATFQPNYVLDPADFLPANRSY 1069
               |:        ||..|.:                   |.:.:||..|.    |.   |.|..:
Zfish   941 SPFFRNCLYNMCVREGNRSALCNSLQAYASACQDAQINLGTWRSATNCPL----PC---PENSHF 998

  Fly  1070 D------------LERAEE----LCGECMQCQYDYAMTLNRDLAHFTKNYYDTIVNMQAENAVRV 1118
            |            |:..||    .|.|..||:..:|:.             |.|...:::
Zfish   999 DECTSACPLTCSNLDEPEEPCPLPCSEGCQCEEGFALR-------------DGICVARSD----- 1045

  Fly  1119 VSCGVLQTPRFGRKLSFDFMPGAKVSFECNEGFILIGDQRRECLSNGLWNIPEYGYTECLREVYY 1183
              ||...   .||:|:            .||.|....:.:..|..||..|.....::.|..|.|.
Zfish  1046 --CGCFY---LGRQLA------------TNETFWTDWECQERCFCNGTDNSVYCTFSPCHPEEYC 1093

  Fly  1184 TRRVAFIAIGIIFLVICPLMLCIVCG 1209
            ....     |:.|.......:|.|.|
Zfish  1094 QENE-----GLFFCQPRTEAMCAVAG 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	49/160 (31%)
		AMOP	660..805	CDD:281737	37/222 (17%)
		VWD	811..999	CDD:214566	45/207 (22%)
		CCP	1121..1171	CDD:214478	12/49 (24%)
tecta	XP_009300199.1	NIDO	100..256	CDD:214712	52/177 (29%)
		VWD	324..480	CDD:278521	28/179 (16%)
		C8	519..594	CDD:214843	11/77 (14%)
		TIL	597..650	CDD:280072	9/54 (17%)
		VWD	717..875	CDD:214566	45/208 (22%)
		C8	913..989	CDD:214843	11/79 (14%)
		TIL	992..1046	CDD:280072	13/76 (17%)
		VWD	1102..1265	CDD:295339	3/13 (23%)
		C8	1349..1420	CDD:285899
		TIL	1424..1477	CDD:280072
		VWC	1479..1532	CDD:302663
		VWD	1539..1690	CDD:278521
		C8	1732..1803	CDD:214843
		ZP	1850..2102	CDD:214579
		Zona_pellucida	1982..2102	CDD:278526
		FXa_inhibition	2132..2166	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10565
eggNOG	1	0.900	-	-		E1_KOG4291
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810