Protein Alignment mesh and Muc4

DIOPT Version :10

• Sequence 1: NP_001163782.1
• Gene: mesh / 43688
• FlyBaseID: FBgn0051004
• Length: 1454
• Species: Drosophila melanogaster
• Sequence 2: XP_063126583.1
• Gene: Muc4 / 303887
• RGDID: 621331
• Length: 3363
• Species: Rattus norvegicus
• Alignment Length: 956
• Identity: 210/956 - (21%)
• Similarity: 324/956 - (33%)
• Gaps: 284/956 - (29%)

  Fly   261 PSDIDQRTPGVYFRVERDLMGRTDRFGVEVRERTMWDIRQGVVGADTFIPKHVVIAT-------- 317
            ||...:|||.|         ..:|.|       |..|...|..|.......|.||.:
  Rat  2108 PSTSSRRTPSV---------ATSDIF-------TTTDSTSGNAGHTLLTGSHSVITSRVASTTLG 2156

  Fly   318 ----------------------WKNVSFAGGIDNSLYTTNTFQMVLATDEVYTYIIFNYAVLNWL 360
                                  .:::..:...:.||.|..|.:...|:....|       |....
  Rat  2157 RLSTVAHSKSTQRSSTHSQSYLTESMGASSTSETSLLTEATTEKQFASSPGPT-------VTETF 2214

  Fly   361 SH-TEAGGDTTKGEGG-----------VPAYVGFNAGNGT---------QAYEYNPYSQNMVIRD 404
            |. |.:.|.|||.:..           :||.....|...|         |.....||..:..:||
  Rat  2215 SRGTSSSGLTTKTDNDRSTALSATSLTLPAPSTSTASRSTVPPAPLPPDQGISLFPYGSSSEVRD 2279

  Fly   405 LANRGWAN-------------GFP-GRHI-----FRVDEQILIGSCNKDIDAALLPLTFAPESGN 450
              .:.:|.             ||| |..:     |..:.||:....:.|:.:...|    |:.|
  Rat  2280 --KQLFARTVDFTSPIFKIQIGFPLGSSLRDSFYFTDNGQIIFPESDYDVFSYPNP----PQRG- 2337

  Fly   451 MLGGQVVNITGPCFDPAIRVTCHFDTESVLGT---------YVDRNRVICVQPYLKAEGYIRFQI 506
            ..|.:.|.|..|.:..|       |..|..||         |.:::::|     .|.|..|....
  Rat  2338 FTGRERVAIVAPFWGDA-------DFSSSRGTIFYQDYITFYDEQHQLI-----RKVESLINEFT 2390

  Fly   507 SVGTQRFKWRGKY-FVETPAAATEKIFFTTDDVHKKNPAEIRITWNQYNLTSNANANVMISLWGY 570
            |..:.:.||..|. :|..||...:..|.|                |.|....:.:.:...:|:.|
  Rat  2391 SDWSFKAKWTLKVTWVNVPAYPAQGSFGT----------------NTYQAILSTDGSRSYALFLY 2439

  Fly   571 RETKIEPQLEYIDVIEASYS------NSGSYVITPSNYINRNNINRDMQFGFLQINLTQPDQY-- 627
            :...:.     .||.:..|:      :||......|..|.|..:.:           .:||::
  Rat  2440 QSGGMR-----WDVTQGLYNRVLMGFSSGDGYFENSPLIFRPAVEK-----------YRPDRFLN 2488

  Fly   628 SGLAISPVLWSRPIPLAWYMAPQWERQHGKRWA--RALCDNWIRADRFLRNFAADLPLCPCTLDQ 690
            |.|.|..:              |..|.|.:.|.  |..|..|:.:.....::..:...|||:..|
  Rat  2489 SKLGIRGL--------------QVYRLHREVWPNYRLKCLQWLESQPQQPSWGWNKISCPCSWQQ 2539

  Fly   691 AVLDKGRFR---------PDRECDKDSNPSCLRHRGAIHCVVSGTPVAQGAEQQCCYDRYGFLML 746
            ...|   ||         ..:.|...|.      ||.: |              |.|..:|
  Rat  2540 GRWD---FRFWLINTGLWGRQLCSFSSG------RGGV-C--------------CSYGTWG---- 2576

  Fly   747 TYDQMWGSRPRRVHNLGKMPWNEASKVPSLSMWFHDMRPFYSCCYWQEEQAVGCETYRFERRPSQ 811
            .:.:.|     |:|:    || :..:......|         ||.|.::.:. |..|:. |||..
  Rat  2577 EFREGW-----RMHS----PW-QFDEEQEAQNW---------CCRWNDKPSF-CVQYQL-RRPRV 2620

  Fly   812 DCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLGEFVLARSVDESNKFEVQGRFEQLPVNYYGEVK 876
            .|..|:.|..|..|||||..|.|...|||||||:|:|.::.|.::.|.::||..|.     ....
  Rat  2621 SCAGYRPPRPAWTFGDPHITTLDNAKYTFNGLGDFLLVQAQDRNSSFLLEGRTAQT-----DSAN 2680

  Fly   877 ATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLDVLADGRRVYFDRESLKFQHFD--GVTVYTPTY 939
            ||...|.|.:.||::.    ..|:..:|....:   |..||..:.:::.|...|  .:.|:..|.
  Rat  2681 ATNFIAFAAQYNTSSL----KSPITVQWFLEPN---DTIRVVHNNQTVAFNTSDTEDLPVFNATG 2738

  Fly   940 LL---NQSQVVVQFDAGIGVEVVENEGYMTGRVFLPWKFINKTAGLFGNWSFNKLDDFMLPNGQV 1001
            :|   |.|||...||..:.:.|:.....:.....|..::.|.|.||.|.|:.|..|||.:|||..
  Rat  2739 VLLIQNGSQVSANFDGTVTISVIALSNILHASSSLSEEYRNHTKGLLGVWNDNPEDDFRMPNGST 2803

  Fly  1002 AQLNLNDLRSIHTNFGIKWMLTDREVPGVGAALFKREFGRMSGYYANATFQPNYVLDPADFLPA- 1065
            ...|.::....|  :|:.|.:....:.||.....                       |::|.|.
  Rat  2804 IPSNSSEETLFH--YGMTWQINGTGLLGVRTDPL-----------------------PSEFTPIF 2843

  Fly  1066 -----NRSYDLERAEELCGECMQCQYDYAMTLNRDLAHFTKNYYDT 1106
                 |:|...|.....|.|..||::|...|.|||:...|.:...|
  Rat  2844 LSQLWNKSGAGEDLISGCNEDAQCKFDILATGNRDIGQSTNSILRT 2889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	42/222 (19%)
		TIG	446..511	CDD:460355	17/73 (23%)
		AMOP	660..803	CDD:461048	28/153 (18%)
		VWD	811..999	CDD:214566	60/192 (31%)
		CCP	1121..1171	CDD:214478
Muc4	XP_063126583.1	None