DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mesh and Muc4

DIOPT Version :9

Sequence 1:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster
Sequence 2:	XP_038944855.1	Gene:	Muc4 / 303887	RGDID:	621331	Length:	3347	Species:	Rattus norvegicus

Alignment Length:	956	Identity:	210/956 - (21%)
Similarity:	324/956 - (33%)	Gaps:	284/956 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 PSDIDQRTPGVYFRVERDLMGRTDRFGVEVRERTMWDIRQGVVGADTFIPKHVVIAT-------- 317
            ||...:|||.|         ..:|.|       |..|...|..|.......|.||.:
  Rat  2092 PSTSSRRTPSV---------ATSDIF-------TTTDSTSGNAGHTLLTGSHSVITSRVASTTLG 2140

  Fly   318 ----------------------WKNVSFAGGIDNSLYTTNTFQMVLATDEVYTYIIFNYAVLNWL 360
                                  .:::..:...:.||.|..|.:...|:....|       |....
  Rat  2141 RLSTVAHSKSTQRSSTHSQSYLTESMGASSTSETSLLTEATTEKQFASSPGPT-------VTETF 2198

  Fly   361 SH-TEAGGDTTKGEGG-----------VPAYVGFNAGNGT---------QAYEYNPYSQNMVIRD 404
            |. |.:.|.|||.:..           :||.....|...|         |.....||..:..:||
  Rat  2199 SRGTSSSGLTTKTDNDRSTALSATSLTLPAPSTSTASRSTVPPAPLPPDQGISLFPYGSSSEVRD 2263

  Fly   405 LANRGWAN-------------GFP-GRHI-----FRVDEQILIGSCNKDIDAALLPLTFAPESGN 450
              .:.:|.             ||| |..:     |..:.||:....:.|:.:...|    |:.|
  Rat  2264 --KQLFARTVDFTSPIFKIQIGFPLGSSLRDSFYFTDNGQIIFPESDYDVFSYPNP----PQRG- 2321

  Fly   451 MLGGQVVNITGPCFDPAIRVTCHFDTESVLGT---------YVDRNRVICVQPYLKAEGYIRFQI 506
            ..|.:.|.|..|.:..|       |..|..||         |.:::::|     .|.|..|....
  Rat  2322 FTGRERVAIVAPFWGDA-------DFSSSRGTIFYQDYITFYDEQHQLI-----RKVESLINEFT 2374

  Fly   507 SVGTQRFKWRGKY-FVETPAAATEKIFFTTDDVHKKNPAEIRITWNQYNLTSNANANVMISLWGY 570
            |..:.:.||..|. :|..||...:..|.|                |.|....:.:.:...:|:.|
  Rat  2375 SDWSFKAKWTLKVTWVNVPAYPAQGSFGT----------------NTYQAILSTDGSRSYALFLY 2423

  Fly   571 RETKIEPQLEYIDVIEASYS------NSGSYVITPSNYINRNNINRDMQFGFLQINLTQPDQY-- 627
            :...:.     .||.:..|:      :||......|..|.|..:.:           .:||::
  Rat  2424 QSGGMR-----WDVTQGLYNRVLMGFSSGDGYFENSPLIFRPAVEK-----------YRPDRFLN 2472

  Fly   628 SGLAISPVLWSRPIPLAWYMAPQWERQHGKRWA--RALCDNWIRADRFLRNFAADLPLCPCTLDQ 690
            |.|.|..:              |..|.|.:.|.  |..|..|:.:.....::..:...|||:..|
  Rat  2473 SKLGIRGL--------------QVYRLHREVWPNYRLKCLQWLESQPQQPSWGWNKISCPCSWQQ 2523

  Fly   691 AVLDKGRFR---------PDRECDKDSNPSCLRHRGAIHCVVSGTPVAQGAEQQCCYDRYGFLML 746
            ...|   ||         ..:.|...|.      ||.: |              |.|..:|
  Rat  2524 GRWD---FRFWLINTGLWGRQLCSFSSG------RGGV-C--------------CSYGTWG---- 2560

  Fly   747 TYDQMWGSRPRRVHNLGKMPWNEASKVPSLSMWFHDMRPFYSCCYWQEEQAVGCETYRFERRPSQ 811
            .:.:.|     |:|:    || :..:......|         ||.|.::.:. |..|:. |||..
  Rat  2561 EFREGW-----RMHS----PW-QFDEEQEAQNW---------CCRWNDKPSF-CVQYQL-RRPRV 2604

  Fly   812 DCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLGEFVLARSVDESNKFEVQGRFEQLPVNYYGEVK 876
            .|..|:.|..|..|||||..|.|...|||||||:|:|.::.|.::.|.::||..|.     ....
  Rat  2605 SCAGYRPPRPAWTFGDPHITTLDNAKYTFNGLGDFLLVQAQDRNSSFLLEGRTAQT-----DSAN 2664

  Fly   877 ATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLDVLADGRRVYFDRESLKFQHFD--GVTVYTPTY 939
            ||...|.|.:.||::.    ..|:..:|....:   |..||..:.:::.|...|  .:.|:..|.
  Rat  2665 ATNFIAFAAQYNTSSL----KSPITVQWFLEPN---DTIRVVHNNQTVAFNTSDTEDLPVFNATG 2722

  Fly   940 LL---NQSQVVVQFDAGIGVEVVENEGYMTGRVFLPWKFINKTAGLFGNWSFNKLDDFMLPNGQV 1001
            :|   |.|||...||..:.:.|:.....:.....|..::.|.|.||.|.|:.|..|||.:|||..
  Rat  2723 VLLIQNGSQVSANFDGTVTISVIALSNILHASSSLSEEYRNHTKGLLGVWNDNPEDDFRMPNGST 2787

  Fly  1002 AQLNLNDLRSIHTNFGIKWMLTDREVPGVGAALFKREFGRMSGYYANATFQPNYVLDPADFLPA- 1065
            ...|.::....|  :|:.|.:....:.||.....                       |::|.|.
  Rat  2788 IPSNSSEETLFH--YGMTWQINGTGLLGVRTDPL-----------------------PSEFTPIF 2827

  Fly  1066 -----NRSYDLERAEELCGECMQCQYDYAMTLNRDLAHFTKNYYDT 1106
                 |:|...|.....|.|..||::|...|.|||:...|.:...|
  Rat  2828 LSQLWNKSGAGEDLISGCNEDAQCKFDILATGNRDIGQSTNSILRT 2873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	42/222 (19%)
		AMOP	660..805	CDD:281737	29/155 (19%)
		VWD	811..999	CDD:214566	60/192 (31%)
		CCP	1121..1171	CDD:214478
Muc4	XP_038944855.1	PHA03247	<4..415	CDD:223021
		PHA03247	<752..1146	CDD:223021
		ser_rich_anae_1	<1862..>2206	CDD:411418	24/136 (18%)
		NIDO	2333..2489	CDD:214712	40/213 (19%)
		AMOP	2491..2601	CDD:413460	29/158 (18%)
		VWD	2616..2786	CDD:395046	57/181 (31%)
		EGF	3262..>3286	CDD:394967
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296951at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13802
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020