DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mesh and Tecta

DIOPT Version :9

Sequence 1:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster
Sequence 2:	NP_001100284.1	Gene:	Tecta / 300653	RGDID:	1309824	Length:	2155	Species:	Rattus norvegicus

Alignment Length:	1248	Identity:	258/1248 - (20%)
Similarity:	394/1248 - (31%)	Gaps:	421/1248 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 FYGFRFNYTRLSLNGYLEFSDPPEYLTYPLVFPIKDWPAKRDPSFMGIFFSKCRVGRIYPSDIDQ 266
            |:|..:....::.||.:.|:......| |..||:.|..|     |:..|:          :|:..
  Rat    57 FFGVPYRTVYVNNNGVVSFNVLVSQFT-PESFPLTDGRA-----FIAPFW----------ADVHN 105

  Fly   267 RTPG-VYFRVERDLMGRTDRFGVEVRERTMWDIRQGVVGADTFIPKHVVIATWKNVSFAGGIDNS 330
            ...| :|:|...|         ..:..|...|||:......||....|.|.||:.|:|.||  :|
  Rat   106 GIRGEIYYRETMD---------SAILRRATKDIRKYFKDMTTFSATWVFIVTWEEVTFYGG--SS 159

  Fly   331 LYTTNTFQMVLATDEVYTYIIFNYAVLNWLSHTEAGGDTTKGEGGVPAYVGFNAGNGTQAYEYNP 395
            ....||||.||.:|..||:.:|||..:||.:.|.:|||...|.|||.|..|||.||.|..:.. |
  Rat   160 TTPVNTFQAVLVSDGSYTFTLFNYYEINWTTGTASGGDPLTGLGGVMAQAGFNGGNLTNFFSL-P 223

  Fly   396 YSQNMVIRDLANRGWANGFPGRHIFRVDEQILIGSCNKDIDAALLPLTFAPESGNMLGGQVV--- 457
            .|:...|.::......| .|||..|:||        .|:||         |.:|....||.:
  Rat   224 GSRTPEIVNIQETTNVN-VPGRWAFKVD--------GKEID---------PANGCTSRGQFLRRG 270

  Fly   458 ---------NITGPCFDPAIRVTCHFDTESVLGTYVDRNRVICVQP-------------YLKAEG 500
                     .|...|.|....:.|...:.|.......:.|.....|             |...:|
  Rat   271 EVFWDDLNCTIKCRCLDFNNEIYCQEASCSPYEVCEPKGRFFYCSPVETSTCVVFGEPHYHTFDG 335

  Fly   501 YIRFQISVGTQRFKWRGK--YFVETPAAATEKIFFTTDDVHKKNPAEIRITWNQYNLTSNANA-N 562
            ::          |.::|.  |.:......|..:.|.:.:...::.....::|.: .|:...|. .
  Rat   336 FL----------FHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRGGSAVSWVK-ELSVEVNGYK 389

  Fly   563 VMISLWGYRETKIEP---------QLEYIDVIEASYSNS------------GSY---VITPSNYI 603
            ::|....|.:.|:..         :|..:.:.::..|.:            |.:   :..|.:||
  Rat   390 ILIPKGSYGKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETDFGLLVTFDGQHYASISIPGSYI 454

  Fly   604 NR-----NNINRDMQFGFLQINLTQPDQYSGLAISPVLWSRPIPLAWYMAPQWERQHGKRWARAL 663
            |.     .|.|::....||     :||            .||......:...|...|......:.
  Rat   455 NSTCGLCGNYNKNPLDDFL-----RPD------------GRPAMSVLDLGESWRVYHTDWKCGSG 502

  Fly   664 C-DNWIRADR-------------FLRNFAADLPLCPCTLDQAVLDKGRFRPDRECDKDSNPSC-L 713
            | ||..:.|.             ||..  .|.||..|   ..|:|...|  ...|..|   .| :
  Rat   503 CIDNCTQCDAATEALYFGSDYCGFLNK--TDGPLWEC---GTVVDATAF--VHSCVYD---LCSV 557

  Fly   714 RHRG----------AIHCVVSGTPVAQ---------------------------------GAEQQ 735
            |..|          |:.|...|.|:..                                 .|.|.
  Rat   558 RDNGTLLCQAIQAYALVCQALGIPIGDWRIQTGCVSTVRCPSFSHYSVCTSSCPDTCSDLTASQN 622

  Fly   736 C-------CYDRYGFLMLTYDQMWGSRPRRVHNLGKMPWNEASKVPSLSMWFHDMRPFY----SC 789
            |       |....||::.|      |:...:|..|          ......::.|..|:    :|
  Rat   623 CATPCTEGCECNEGFVLST------SQCVPLHKCG----------CDFEGHYYTMGEFFWATANC 671

  Fly   790 ---CYWQEEQAVGCETYRFER--RPSQDCVAYQAPGIAGVFGDPHFV----------TFDGTAYT 839
               |..:|    |.:.|.|.:  |..:.|..  ..|..|.|.....|          ||||.||.
  Rat   672 TVQCLCEE----GGDVYCFNKTCRSGEVCAV--EDGYQGCFPKRETVCLLSQNQVLHTFDGAAYA 730

  Fly   840 FNGLGEFVLARSVDESNKFEVQGRFEQLPVNYYGEVKATQLTAVAMRGNTTTTI--EVRLRPLHA 902
            |.....:.|.::..|        |.|.|.::.  ..:........:||......  ||::..:.|
  Rat   731 FPSELSYTLLKTCPE--------RPEYLEIDI--NKRKPDAGPAWLRGVRILVADQEVKIGGVGA 785

  Fly   903 RWRYRLDVLADGRRVYFDRESLKFQHFDG-VTVYTPTYLLNQSQVVVQFDAGIGVEVVENEGYMT 966
                 |:|..:|..|     .|.|.|..| :.::.     |::...|:....:.|:..:     .
  Rat   786 -----LEVKLNGHDV-----ELPFFHPSGRLEIHR-----NKNSTTVESKGVVSVQYSD-----V 830

  Fly   967 GRVF--LPWKFINKTAGLFGNWSFNKLDDFMLPNGQVAQLNLNDLRSIHTNFG----------IK 1019
            |.::  |...:.|.|.||.|.::.|..|:|.||||:... ||.......|.|.          :|
  Rat   831 GLLYIRLSTMYFNCTGGLCGFFNANASDEFCLPNGKCTD-NLAVFLESWTTFEEICNGECGDLLK 894

  Fly  1020 WMLTDREV---------------PGVGAALFKREFGRMSGYYANATFQ-------PNYVLDP-AD 1061
            ....|.|:               |...:.|.......::.||....|:       .:.:.|. |.
  Rat   895 ACNNDSELLKFYRSRSRCGIINDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVAR 959

  Fly  1062 FLPANRSYDLE----RAEELC----------GECMQCQYDYAMTLNRDLAHFTKNYYDTIVNMQA 1112
            :..|.::.|:|    |..:.|          .|||.|. :...||                   |
  Rat   960 YASACKNADVEVGPWRTYDFCPLECPENSHFEECMTCT-ETCETL-------------------A 1004

  Fly  1113 ENAVRVVSCGVLQTPRFGRKLSFDFMPGAKVSFECNEGFILIGDQ---RRE-------------- 1160
            ...:.|.||                    ....:|:||:.|.|.|   |.|
  Rat  1005 LGPICVDSC--------------------SEGCQCDEGYALQGSQCVTRSECGCNFEGHQLATNE 1049

  Fly  1161 -----------CLSNGLWN------IPEYGYTECLRE--VYYTR--------------RVAFIAI 1192
                       |..||..|      ||......|:.|  :||.:              .:.|...
  Rat  1050 TFWVDQDCQIFCYCNGTDNSVHCETIPCRDDDYCMEESGLYYCQPRTDASCIVSGYGHYLTFDGY 1114

  Fly  1193 GIIFLVICPLMLC 1205
            ...|...|||:||
  Rat  1115 PFDFQTSCPLILC 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	56/160 (35%)
		AMOP	660..805	CDD:281737	39/216 (18%)
		VWD	811..999	CDD:214566	45/202 (22%)
		CCP	1121..1171	CDD:214478	14/83 (17%)
Tecta	NP_001100284.1	NIDO	98..254	CDD:214712	61/186 (33%)
		VWD	322..478	CDD:278521	26/183 (14%)
		C8	517..591	CDD:214843	18/83 (22%)
		TIL	597..650	CDD:280072	9/58 (16%)
		VWC	652..706	CDD:302663	12/59 (20%)
		VWD	703..865	CDD:214566	43/191 (23%)
		C8	905..981	CDD:214843	11/75 (15%)
		TIL	984..1036	CDD:280072	17/91 (19%)
		VWD	1100..1258	CDD:278521	7/28 (25%)
		C8	1298..1368	CDD:285899
		TIL	1372..1425	CDD:280072
		VWD	1487..1639	CDD:278521
		C8	1685..1757	CDD:214843
		ZP	1805..2059	CDD:214579
		Zona_pellucida	1937..2057	CDD:278526
		FXa_inhibition	2089..2121	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9412
eggNOG	1	0.900	-	-		E1_KOG4291
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810