DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mesh and Susd2

DIOPT Version :9

Sequence 1:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster
Sequence 2:	XP_006256400.2	Gene:	Susd2 / 294335	RGDID:	1308595	Length:	825	Species:	Rattus norvegicus

Alignment Length:	870	Identity:	258/870 - (29%)
Similarity:	391/870 - (44%)	Gaps:	119/870 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 MVIRDLANRGWANGFPGRHIFR--VDEQIL--------IGSCNKDIDAALLPLTFAPESGNMLGG 454
            |::..:...|...|.||....|  |.::|.        :|:|.||.....|.:  :|.||:|:||
  Rat    11 MLLSTIPGPGLTAGTPGSCSLRCGVQDEICSCHPTCSGLGTCCKDFLNYCLEI--SPSSGSMMGG 73

  Fly   455 -----QVVNITGPCFDPAIRVTCHFDTESV--LGTYVDRNRVICVQPYLKAEGYIRFQISVGT-Q 511
                 |.:..|    |....|.|.| .||:  ||...|..:|.|:.|.|...|:|.|.||:.. .
  Rat    74 KDFVVQHLKWT----DSITSVICRF-KESIQTLGYVDDLKQVHCISPLLYESGHIPFTISMDNGL 133

  Fly   512 RFKWRGKYFVETPAAATEK-----------IFFTTDDVHKKNPAEIRITWNQYNLTSNANANVMI 565
            .|...|.:....|...:|.           .::.|.|    ....:.:|||...|.:.   .|.|
  Rat   134 SFPHAGTWLAAHPYKVSESEKSQLVNETHWQYYGTSD----TGGNLSLTWNTSALPTR---TVTI 191

  Fly   566 SLWGYRET------KIEPQLEYIDVIEASYSNSGSYVITPS----NYINRNNINRDMQFGFLQIN 620
            .||||.||      ....:..|:..:..:..|:|.:..||.    .|       :..:.|.|:|
  Rat   192 ELWGYEETGTPYTGNWTAKWSYLYPLATNIPNTGFFTFTPKPAPPQY-------QRWRVGALRI- 248

  Fly   621 LTQPDQYSGLAISPVLWSRPIPLAWYMAPQWERQHGKRWARALCDNWIRADRFLRNFAADLPLCP 685
             .....|:|......||:....|||::...: |.....|||..|..|...:..|.||..:||.||
  Rat   249 -IGSKNYAGEQDVLALWTNDHALAWHLGDDF-RADSVAWAREQCLTWEALEDQLPNFLTELPDCP 311

  Fly   686 CTLDQAVLDKGRFRPDRECDKDSNPSCLRHRGAIHCV--VSGTPVAQGAEQQCCYDRYGFLMLTY 748
            |||.||..|.|||..|..||.:....|..|.||:|||  |..:|: .|:.|||||...|..:||.
  Rat   312 CTLAQARADSGRFFTDYGCDIEHGSVCTYHPGAVHCVRSVQASPM-YGSGQQCCYTASGTQLLTS 375

  Fly   749 DQMWGSRPRRVHNLGKMPWNEASKVPSLSMWFHDMRPFYSCCYWQEEQAVGCETYRFERRPSQDC 813
            |...||.|.|.|:.|..|:....:||.:|.|.:|:..||.||.|..|    |..| .:||||.||
  Rat   376 DSTSGSTPDRGHDWGAPPYRSPPRVPGMSHWLYDVISFYYCCLWAPE----CPRY-MKRRPSSDC 435

  Fly   814 VAYQAPGIAGVFGDPHFVTFDGTAYTFNGLGEFVLARSVDES---NKFEVQGRFEQLPVNYYGEV 875
            .:|:.|.:|..||||||||||||:::|:|.||:||..:::.:   ....||||.:...:....:.
  Rat   436 RSYRPPRLASAFGDPHFVTFDGTSFSFSGNGEYVLLETLETAAAVKDLRVQGRAQPGRMPNGTQA 500

  Fly   876 KATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLDVLADGRRVYFDRESLKFQHFDGVTVYTPTYL 940
            :.|.|||||::.:.:..||||:    |.....|:||.:.:.:.|..::  :....|:.:    .:
  Rat   501 RGTGLTAVAVQEDKSDVIEVRV----ADGSQVLEVLLNQKLLSFTEQN--WMDLKGMFL----SV 555

  Fly   941 LNQSQVVVQFDAGIGVEVVENEGYMTGRVFLPWKFINKTAGLFGNWSFNKLDDFMLPNGQVAQLN 1005
            .:|.:|.:...:|.|:||.....:::..:.||.||::.|.||.|..:.|..|||.|.||.|...|
  Rat   556 ASQDKVSIMLSSGAGLEVGVQGPFLSVSILLPEKFLSHTRGLLGTLNDNPEDDFTLRNGHVLPPN 620

  Fly  1006 LNDLRSIHTNFGIKWMLTDREVPGVGAALFKREFGRMSGYYANA-TFQPNYVLDPADFLPANRSY 1069
            ....:..  .||..|.:::      .::||..:...:...:.|. ...||:    ....|...:.
  Rat   621 ATAQQLF--QFGANWAISN------ASSLFTYDSRPLVNQFLNGPKHDPNF----KPLFPDETTL 673

  Fly  1070 DLERAEELCGECMQ---CQYDYAMTLNRDLAHFTKNYYDTIVNMQAENAVR----VVSCGVLQTP 1127
            ...:||:|...|..   |..|...|.:..:.:.|:     |.:...::.::    |||||.|..|
  Rat   674 SPSQAEDLARLCESDHFCVLDVISTGDPSVGNATR-----IAHQLHQHRLKSLQPVVSCGWLPPP 733

  Fly  1128 RFGRKLSFDFMPGAKVSFECNEGFILIGDQRRECLSNGLWNIPEYGYTECLREVYYTRRVAFIAI 1192
            ..|.|....::.|:.|.|.||.|:.|.|.:...|.::|.|:.|.   .||.....||     :.:
  Rat   734 VNGHKEGLKYLEGSTVRFGCNSGYSLAGPESSTCRADGTWSSPT---PECQPGRNYT-----VLL 790

  Fly  1193 GIIF--LVICPLMLCIVCGVYRYRQ 1215
            .|||  |.|..|:..:...::|.|:
  Rat   791 SIIFGGLAIVALISIVFMLLHRRRK 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	5/18 (28%)
		AMOP	660..805	CDD:281737	62/146 (42%)
		VWD	811..999	CDD:214566	62/190 (33%)
		CCP	1121..1171	CDD:214478	17/49 (35%)
Susd2	XP_006256400.2	Somatomedin_B	27..62	CDD:395820	8/34 (24%)
		AMOP	286..428	CDD:397723	62/147 (42%)
		VWD	444..614	CDD:413350	58/179 (32%)
		CCP	727..781	CDD:153056	19/56 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335361
Domainoid	1	1.000	116	1.000	Domainoid score	I5863
eggNOG	1	0.900	-	-		E1_KOG4291
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10481
Inparanoid	1	1.050	309	1.000	Inparanoid score	I2538
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296951at33208
OrthoFinder	1	1.000	-	-		FOG0007412
OrthoInspector	1	1.000	-	-		oto96408
orthoMCL	1	0.900	-	-		OOG6_107727
Panther	1	1.100	-	-	O	PTHR13802
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5542
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800