Protein Alignment mesh and R09E10.5

DIOPT Version :10

• Sequence 1: NP_001163782.1
• Gene: mesh / 43688
• FlyBaseID: FBgn0051004
• Length: 1454
• Species: Drosophila melanogaster
• Sequence 2: NP_501890.2
• Gene: R09E10.5 / 187743
• WormBaseID: WBGene00011175
• Length: 1437
• Species: Caenorhabditis elegans
• Alignment Length: 1462
• Identity: 337/1462 - (23%)
• Similarity: 528/1462 - (36%)
• Gaps: 448/1462 - (30%)

  Fly   140 PPTTYSTAAGGY-----------TITAARLAELRSNFMYWYFDKDMYGGRGDYQF---------- 183
            ||..|:...||.           ||......::             :.|.|:..|
 Worm    20 PPLAYNQNIGGINQNIGGTPQNPTINQVSPGQI-------------FSGTGNNPFYGVNLVPFGP 71

  Fly   184 ---DIHASMTQLHKNLNFQL----PFYGFRFNYTRLSLNGYLEFS----DPPEYLTYPLVFPIKD 237
               |:..:.:.|...:...|    |:||..:|||.:|:||||.|:    ..|.....|   ...|
 Worm    72 EAGDLMVNPSMLTSGMTIDLYMFFPYYGGLYNYTTISVNGYLGFATVLDQGPTINVGP---ETTD 133

  Fly   238 WPAKRDPSFMGIFFSKCRVGRIYPSDIDQRTPGVYFR--VERDLMGRTDR--------------F 286
            ||.:.||:.:..:..|.:|.:   .....|..|||:|  :.:.|.||...              |
 Worm   134 WPRQEDPAMIAPYLCKQQVPQ---QGNPARRAGVYYRLLLRQSLFGRESNSNLNLGGTLQQNAFF 195

  Fly   287 GVE------------VR----------ERTMWDIRQGVVGADTFIPKHVVIATWKNVSFA--GGI 327
            |.:            ||          :..:| :::||.|...|.....|:.||.|.:.|  |..
 Worm   196 GQQASQACPGTADSYVRCDSNSDYFLDQMMIW-VQEGVAGGAMFRADAAVVVTWYNTASAISGRS 259

  Fly   328 DNSLYTTNTFQMVLATDEV--YTYIIFNYAVLNWLSHTEAGGDTTKGEGGVPAYVGFNAGNGTQA 390
            |.....|.|:|::..||..  .:|:|.||..|.: ...:..|::..|.    ....||.||.|..
 Worm   260 DIDAGQTGTYQVIWLTDSTARLSYVIINYDRLGF-DAQDFRGNSRSGR----CRAVFNGGNHTGT 319

  Fly   391 YEYN---PYSQNMVIRDLANRGWANGFP----GRHIFRVDEQILIGSC-NKDIDAALLPLTFAPE 447
            .|.:   ||.....:  ||.|   :|.|    ||::||||:.:....| ||  .....|:...|.
 Worm   320 VEVDPTQPYKNTPKV--LAQR---SGVPHMVRGRYMFRVDDVVRPAGCSNK--TGGTYPIMIYPN 377

  Fly   448 SGNMLGGQVVNITGPCFDPAIRVTCHFDTESVLGTYVDRNRVIC--VQPYLKAEGYIRFQISVGT 510
            ..||||...|::...|.|         .|::.:....:|....|  :.|.:......|.
 Worm   378 IVNMLGDMTVDVNACCLD---------RTQTYIMMIEEREVATCQVINPAIARCSLPRI------ 427

  Fly   511 QRFKWRGK--YF-VETPAAATEKIFF--------TTDDVH---------KKNPAE---IRITWNQ 552
              :.|..|  || .|:..|..||.|.        |.|.:.         .|||..   :.|||..
 Worm   428 --YDWGTKTVYFQPESRGANDEKAFVGYIYFVPPTLDPMRLDIGNIYEWYKNPMTNYLMPITWYP 490

  Fly   553 YN------LTSNANANVMIS------------LWGYRE------TKIEPQLEYIDVIEASYSNSG 593
            .|      ||:..|..|.||            :.||||      .|..|:...:..| .:|||..
 Worm   491 RNFTNPDILTNGNNMGVRISDDSMYGVQLGLYIVGYREFKDDEIKKFRPEYRTLARI-TTYSNQN 554

  Fly   594 SYVITPSNY--------INRNNINR-------------DMQFGFLQINLTQPDQYSGLAISPVLW 637
            :     :||        ||.|.:.:             ..:.||.::....|:..:|..:.|.|.
 Worm   555 N-----ANYRWMPQEEVINTNQVQQWYLTDWERMHTLYTYRVGFFKLAPINPNDANGTQLLPGLV 614

  Fly   638 SRPIPLAWYMAPQWER---------------QHGKRWARALCDNWIRADRFLRNFAADLPL---C 684
            |.||.|.|...|:.::               :..|..:|.:|.:|...|..|.||..|...   |
 Worm   615 SAPISLHWLWTPENQQFATLTLNQQDRDQRIEFVKEKSREMCHDWYDEDGALWNFIRDTETNTSC 679

  Fly   685 PCTLDQAVLDKGRFRPDRECDK-DSNPSCLRHRGAIHCVVSGTPVAQGAE--------------- 733
            ||...||:||.|||.|...|.: ..:.:|....|:.:|.:|.:.:.....
 Worm   680 PCIETQALLDLGRFMPHPRCSQMFRDITCTTVIGSKNCYMSSSNIYSSYAGNGNTFNNMDTNRFM 744

  Fly   734 ----QQCCYDRYGFLMLT-YDQMWGSR---------PRRVHNLGKMPWNEASKVPSLSMWFHDMR 784
                |.||||..|:||.| |..:..::         |.|.:..|..|:....:||.||::.:|..
 Worm   745 THYGQVCCYDESGYLMQTPYQPVIKTQREYFYNPGYPLRAYEFGTAPYMGQFEVPGLSVFHNDYM 809

  Fly   785 PFYSCCYWQEEQAVGCETYRFERRPSQDCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLGEF--- 846
            |::.||.:.:.:   |:.: :.||||..|..||.|.|....|...|.|.|...:.||..|.|
 Worm   810 PYFLCCKFADFR---CQMF-YWRRPSSACQQYQPPAIGHAQGAGVFQTIDNDKFIFNQPGVFNFL 870

  Fly   847 VLARSVDESNKFEVQGRFEQLP------------VNYYGEVK---ATQLTAVAMRGNTTTTIEVR 896
            .:.:|| .:.:..:|.|.|:.|            ::.|..|:   ||.:|.:|:....|..:.|.
 Worm   871 YIPQSV-RTPEVRIQTRLERYPNRKVDFGLLGRYISQYELVQPTNATVITGIALEATGTERVIVM 934

  Fly   897 LRPLHARWRYRLDVLADGRRVYFDRESLKFQHFDGVTVYTPTYLLNQSQV-VVQFDAGIGVEVVE 960
            .|....|:|||.:::......|||  :::.|.|.||.:|.......|.:: ||..:|.|||:|.|
 Worm   935 TRKDTRRFRYRTNIIVGNILRYFD--TIRLQRFRGVLIYVNNVERGQPEIYVVLEEAQIGVKVTE 997

  Fly   961 NEGYMTGRVFLPWKFINKTAGLFGNW--SFNKLD--------DFMLPNGQVAQ------------ 1003
            :......|  ||            |:  |...||        ..:.|:|...|
 Worm   998 SYALDIDR--LP------------NYQESMGMLDIQISVSPQYGVRPDGDKTQETQYRQMYNLPR 1048

  Fly  1004 -------------------LNLNDLRS------IHTNFGI-----------------------KW 1020
                               |.|||:.|      |..|:.:                       ..
 Worm  1049 VSGLIRPYPDQTSGSLNEGLTLNDVNSDSYRQQIINNYLVLGTGEPGTQQNQAGTLNQNMPQDNM 1113

  Fly  1021 MLTDRE--------------------------------VPGVGAALFKREFGRMSGYYANATFQP 1053
            ..|.|:                                ||..||.:.     ::.....:....|
 Worm  1114 FTTSRDEDKQFDVFPEASMRSEPVYKTAPIFDTGSYRFVPQTGAMIL-----QLLNTCRDLQNNP 1173

  Fly  1054 NYVLDPADFLPANRSYDLERAEE------LCGECMQCQYDYAMTLNRDLAHFTKNYYDTIVNMQA 1112
            |..|.|...: |..||.|:..::      .||:.:.|.||||:..::.|....::.::.....:|
 Worm  1174 NTDLQPYQSI-ATLSYGLQCPDDPGQVLTECGDSVACLYDYALLNSKVLGQEEQDAWNMFTTDRA 1237

  Fly  1113 ENAVRVVSCGV--LQTPRFGRK---LSFDFMPGAKVSFECNEGFILIGDQRRECLSNGL---WNI 1169
            ....:..|||.  ::.|.:..|   ||..::.|....|||.:...:.||...:|   |:   :|.
 Worm  1238 LAIRQYNSCGAINIEYPEYMMKTPALSSGYLQGDVARFECYQSHWVKGDHEYKC---GIVVDYNR 1299

  Fly  1170 P-EYGY----------TECLREVYYTRRVAFIAIGIIFLVICPLMLCIVCGVYRYRQKQLKEDPQ 1223
            | ||.:          ...::|.|: :.:|.|| ||:.::|..|::.:|  .:..::|:|:|...
 Worm  1300 PNEYRFEWNKGNQPWCRSRIKENYF-KWLAVIA-GIVGIIIVILLIFLV--FWCIKRKKLQESRN 1360

  Fly  1224 W-------------QMPMLPRSRASSARNLRT 1242
            :             |......|||.|..:|.|
 Worm  1361 YSGTAAYSNNAFQNQTYETKPSRALSVGDLST 1392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	51/208 (25%)
		TIG	446..511	CDD:460355	13/66 (20%)
		AMOP	660..803	CDD:461048	47/175 (27%)
		VWD	811..999	CDD:214566	57/216 (26%)
		CCP	1121..1171	CDD:214478	16/58 (28%)
R09E10.5	NP_501890.2	NIDO	194..358	CDD:214712	47/174 (27%)
		AMOP	648..829	CDD:128962	48/184 (26%)