DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mesh and F54D1.6

DIOPT Version :9

Sequence 1:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster
Sequence 2:	NP_502119.2	Gene:	F54D1.6 / 178037	WormBaseID:	WBGene00010047	Length:	1423	Species:	Caenorhabditis elegans

Alignment Length:	1437	Identity:	315/1437 - (21%)
Similarity:	504/1437 - (35%)	Gaps:	420/1437 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 NLNFQLPFYGFRFNYTRLSLNGYLEFS----DPPEYLTYPLVFPIKDWPAKRDPSFMGIFFSKCR 255
            :|:...||||..:||:.||:|||:.|:    ..|.....|   .:.|||...||:.:..:..|.:
Worm    81 DLHMYFPFYGGLYNYSTLSVNGYIGFATVLDQGPTLNVGP---DMTDWPRHEDPAMIAPYLCKQQ 142

  Fly   256 VGRIYPSDIDQ-RTPGVYFR--VERDLMGR--------------TDRFGVE-------------- 289
            :    |.:::. ...||::|  :.:.|.||              :..||..
Worm   143 I----PQNLNPGMRSGVFYRLMMRQSLFGRQTGSNMNMGQATYQSSFFGQSASKACPGTPDSYVR 203

  Fly   290 --------VRERTMWDIRQGVVGADTFIPKHVVIATWKNVSFA--GGIDNSLYTTNTFQMVLATD 344
                    :.|...|.| :||.||..|.....::.||.|.:.|  |..|.......|:|.:..||
Worm   204 CDSQADYFLEEMQRWLI-EGVAGAAAFRADAALVVTWYNTASAISGRSDIDSGQLATYQAIWLTD 267

  Fly   345 EV--YTYIIFNYAVLNWLSHTEAGGDTTKGEGGVPAYVGFNAGNGTQAYEYNPYSQNM--VIRDL 405
            ..  .:|:|.||..|.:     ...|..:..........||.||.|.....:| :|:.  ..:.|
Worm   268 RTARLSYVILNYDRLGF-----DAADFRQNSRSGRCQALFNGGNHTGLVPVDP-TQDFKNTPKVL 326

  Fly   406 ANRGWANGFP----GRHIFRVDEQILIGSC-NKDIDAALLPLTFAPESGNMLGGQVVNITGPCFD 465
            |.|   :|.|    ||::||||:.:....| ||  .....|:...|...||||...|::...|.|
Worm   327 AQR---SGVPQMVRGRYMFRVDDVVRPAGCSNK--TGGTYPMLIYPNIVNMLGEMTVDVNAICLD 386

  Fly   466 PA----------IRVTCHFDTESVLGTYVDRNRVICVQPYLKAEGYIRFQISVGTQRFKWRGK-- 518
            .:          ...||     :||.:.:.|    |..|.:                |.|..|
Worm   387 KSQTYILMIEQRQTATC-----TVLTSAIAR----CNLPKI----------------FDWGTKTV 426

  Fly   519 YFVETPAAATEK------IFF---TTDDVHK---------KNP---AEIRITWNQYNLTS----- 557
            ||......|.::      |:|   |.|.:..         |||   ..:.:.|...|.|:
Worm   427 YFQPQSGGANDEKAFVGYIYFVPPTLDPMRLDIGNVYDWFKNPLPYTTMPLVWYPRNFTNPEMTQ 491

  Fly   558 -----NANANVMIS------LWGYRE------TKIEPQLEYIDVIEASYSNSGSYVI--TPSN-- 601
                 ..|.:.:.|      :..|||      .|..|:...|..: |:|||..:|..  .|..
Worm   492 HMDQVRMNDDTLYSTQLGLYVIAYREYKDDTIKKFRPEHRVICRL-ATYSNRNTYEYRWKPQEER 555

  Fly   602 ---------YIN---RNNINRDMQFGFLQI-----NLTQ-PDQ-YSGLAISPV----LWSRPIPL 643
                     |:|   |.|.....:||:|::     |..| |.| .|||..||:    ||:...|
Worm   556 INLYQVEQWYMNDWERQNDLYHYRFGYLKLAPLKTNQEQNPQQLLSGLVSSPISLHFLWTSNNP- 619

  Fly   644 AWYMAPQWERQ-------HGKRWARALCDNWIRADRFLRNFAADLPL---CPCTLDQAVLDKGRF 698
             .:....:.:|       :.|:.:..:|.:|...|....||..|...   |||...||:.|.|||
Worm   620 -QFATTTYSQQDESARTEYVKKKSLEMCHDWYDEDGAQWNFIRDTETNSSCPCIERQAIADIGRF 683

  Fly   699 RPDRECDKD-SNPSCLRHRGAIHCVVSG-----TPVAQGAE-------------QQCCYDRYGFL 744
            .|...|.:. .:.:|....|:.:|.:|.     |....|.:             |.||||..|.|
Worm   684 MPHPRCSQAFRDITCTTSIGSRNCYMSSQNVMTTYAGDGRQYNENLARFPTHYGQVCCYDDQGHL 748

  Fly   745 MLT-------------YDQMWGSRPRRVHNLGKMPWNEASKVPSLSMWFHDMRPFYSCCYWQEEQ 796
            |.|             |:..:   |.|.:..|..|:....:||.||.:.:|..|::.||.:.:.:
Worm   749 MQTSYQPVIKVTPEVPYNPGF---PMRAYEFGTAPYMGQYEVPGLSAFHNDYMPYFLCCKFADFR 810

  Fly   797 AVGCETYRFERRPSQDCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLGEF--VLARSVDESNKFE 859
               |:.: :.||||..|..||.|....|.|...|.|.|...:.||..|.:  :.......:.:.:
Worm   811 ---CQMF-YWRRPSSGCQEYQPPAYGEVMGAGTFNTIDNDKFIFNEPGVYNGLYIPHTLSTPEVK 871

  Fly   860 VQGRFEQLP---------VNYYGE------VKATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLD 909
            ||.|.|:.|         ..|..:      ..||.:|.|.:....|..:.|..|....|:|||..
Worm   872 VQIRMERYPNRRVDFSLLGRYMAQQDLVQPTNATVVTGVVLEATGTDRVHVVARKDTRRFRYRTS 936

  Fly   910 VLADGRRVYFDRESLKFQHFDGVTVYTPTYLLNQSQV-VVQFDAGIGV--------------EVV 959
            ::......|||  :::.|.|.||.:|.......|.:: ||..:|.||:              |..
Worm   937 IIVGNILRYFD--TMRIQRFKGVMIYVNNVERGQPEIYVVLEEAQIGIRVRESYAIDIDRLSEYQ 999

  Fly   960 ENEGYMTGRVFLPWKF-------------------INKTAGLFGNWSFNKLDDFMLPNGQVAQLN 1005
            |:.|.:...|.:|.::                   :.:.:|:|..:.......::      ..|.
Worm  1000 ESMGILNIAVSVPPQYGVRPDGDKTREQEIRQRYNLPRVSGVFRPFPDQSSGSYL------NTLT 1058

  Fly  1006 LNDLRS------------------------IH---TNFGI---KWMLTDR----------EVPGV 1030
            |||:.|                        |:   .|:|:   ....|.|          |....
Worm  1059 LNDVNSETYRQQIINMYRVQGSGEPGSDQNINNQGNNYGMPTENMFTTSRDEDKKFEVFPEAQMK 1123

  Fly  1031 GAALFKR---------EFGRMSGYYANATFQ--------PNYVLDPADF----------LPANRS 1068
            ...:||.         .|..|:|...|...|        .|..:.|...          .|.|.|
Worm  1124 SGPIFKTSPKYETGAYRFYPMTGQVLNQRLQTCRDMQQNTNINMQPLQSQLTGEYGQTQCPDNPS 1188

  Fly  1069 YDLERAEELCGECMQCQYDYAMTLNRDLAHFTKNYYDTIVNMQAENAVRVVSCGV--LQTPRFGR 1131
            ..::.    ||:.:.|.|||.....:.|....||.::|..:.:.:.:.:..||||  ::.|.:..
Worm  1189 SIIQD----CGDSVPCLYDYYNFNAKLLGLNVKNEWNTFTSDRFDASRQYNSCGVINIEYPEYLM 1249

  Fly  1132 K---LSFDFMPGAKVSFECNEGFILIGDQRRECLSNGL------------------WNIPEYGYT 1175
            |   :|..::.|....|||.:...:.|....:|   |:                  ||..|..:.
Worm  1250 KTSSMSSAYLQGDVARFECFQSHWIYGVHEYKC---GIVVDRNQRNIIDPRDYRFEWNKGEQPWC 1311

  Fly  1176 ECLREVYYTRRVAFIAIGIIFLVICPLMLCIVCGVYRYRQKQLKEDPQWQMPMLPRSRASSARNL 1240
            ....:..:...:|.|. ||..:::..:::.:.|.:.:.::|               ..|:..|
Worm  1312 RSREKQNFLTWLAIIG-GIFGVLVFVILIFLCCWIVKQKKK---------------GEAAERR-- 1358

  Fly  1241 RTLNYDDDSDTDASTLKKSRSYDKVYRTNEPLPGKPQIDFPAKKWDLDE-NDEDVTSSEGEKPKQ 1304
               .||..|.:..:..:..:.|.  ...:|||        ..|::|.|. .|:|......|:...
Worm  1359 ---GYDMASRSSMTGSRGGKKYP--IHESEPL--------NEKRFDADTYRDDDFYPPAREEQYA 1410

  Fly  1305 LGRRSLH 1311
            .....||
Worm  1411 ARNEDLH 1417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	47/208 (23%)
		AMOP	660..805	CDD:281737	46/179 (26%)
		VWD	811..999	CDD:214566	50/238 (21%)
		CCP	1121..1171	CDD:214478	15/72 (21%)
F54D1.6	NP_502119.2	NIDO	185..349	CDD:295411	44/173 (25%)
F54D1.6	NP_502119.2	AMOP	638..818	CDD:128962	47/186 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4291
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7078
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296951at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770