Protein Alignment mesh and F54D1.6

DIOPT Version :10

• Sequence 1: NP_001163782.1
• Gene: mesh / 43688
• FlyBaseID: FBgn0051004
• Length: 1454
• Species: Drosophila melanogaster
• Sequence 2: NP_502119.2
• Gene: F54D1.6 / 178037
• WormBaseID: WBGene00010047
• Length: 1423
• Species: Caenorhabditis elegans
• Alignment Length: 1437
• Identity: 315/1437 - (21%)
• Similarity: 504/1437 - (35%)
• Gaps: 420/1437 - (29%)

  Fly   195 NLNFQLPFYGFRFNYTRLSLNGYLEFS----DPPEYLTYPLVFPIKDWPAKRDPSFMGIFFSKCR 255
            :|:...||||..:||:.||:|||:.|:    ..|.....|   .:.|||...||:.:..:..|.:
 Worm    81 DLHMYFPFYGGLYNYSTLSVNGYIGFATVLDQGPTLNVGP---DMTDWPRHEDPAMIAPYLCKQQ 142

  Fly   256 VGRIYPSDIDQ-RTPGVYFR--VERDLMGR--------------TDRFGVE-------------- 289
            :    |.:::. ...||::|  :.:.|.||              :..||..
 Worm   143 I----PQNLNPGMRSGVFYRLMMRQSLFGRQTGSNMNMGQATYQSSFFGQSASKACPGTPDSYVR 203

  Fly   290 --------VRERTMWDIRQGVVGADTFIPKHVVIATWKNVSFA--GGIDNSLYTTNTFQMVLATD 344
                    :.|...|.| :||.||..|.....::.||.|.:.|  |..|.......|:|.:..||
 Worm   204 CDSQADYFLEEMQRWLI-EGVAGAAAFRADAALVVTWYNTASAISGRSDIDSGQLATYQAIWLTD 267

  Fly   345 EV--YTYIIFNYAVLNWLSHTEAGGDTTKGEGGVPAYVGFNAGNGTQAYEYNPYSQNM--VIRDL 405
            ..  .:|:|.||..|.:     ...|..:..........||.||.|.....:| :|:.  ..:.|
 Worm   268 RTARLSYVILNYDRLGF-----DAADFRQNSRSGRCQALFNGGNHTGLVPVDP-TQDFKNTPKVL 326

  Fly   406 ANRGWANGFP----GRHIFRVDEQILIGSC-NKDIDAALLPLTFAPESGNMLGGQVVNITGPCFD 465
            |.|   :|.|    ||::||||:.:....| ||  .....|:...|...||||...|::...|.|
 Worm   327 AQR---SGVPQMVRGRYMFRVDDVVRPAGCSNK--TGGTYPMLIYPNIVNMLGEMTVDVNAICLD 386

  Fly   466 PA----------IRVTCHFDTESVLGTYVDRNRVICVQPYLKAEGYIRFQISVGTQRFKWRGK-- 518
            .:          ...||     :||.:.:.|    |..|.:                |.|..|
 Worm   387 KSQTYILMIEQRQTATC-----TVLTSAIAR----CNLPKI----------------FDWGTKTV 426

  Fly   519 YFVETPAAATEK------IFF---TTDDVHK---------KNP---AEIRITWNQYNLTS----- 557
            ||......|.::      |:|   |.|.:..         |||   ..:.:.|...|.|:
 Worm   427 YFQPQSGGANDEKAFVGYIYFVPPTLDPMRLDIGNVYDWFKNPLPYTTMPLVWYPRNFTNPEMTQ 491

  Fly   558 -----NANANVMIS------LWGYRE------TKIEPQLEYIDVIEASYSNSGSYVI--TPSN-- 601
                 ..|.:.:.|      :..|||      .|..|:...|..: |:|||..:|..  .|..
 Worm   492 HMDQVRMNDDTLYSTQLGLYVIAYREYKDDTIKKFRPEHRVICRL-ATYSNRNTYEYRWKPQEER 555

  Fly   602 ---------YIN---RNNINRDMQFGFLQI-----NLTQ-PDQ-YSGLAISPV----LWSRPIPL 643
                     |:|   |.|.....:||:|::     |..| |.| .|||..||:    ||:...|
 Worm   556 INLYQVEQWYMNDWERQNDLYHYRFGYLKLAPLKTNQEQNPQQLLSGLVSSPISLHFLWTSNNP- 619

  Fly   644 AWYMAPQWERQ-------HGKRWARALCDNWIRADRFLRNFAADLPL---CPCTLDQAVLDKGRF 698
             .:....:.:|       :.|:.:..:|.:|...|....||..|...   |||...||:.|.|||
 Worm   620 -QFATTTYSQQDESARTEYVKKKSLEMCHDWYDEDGAQWNFIRDTETNSSCPCIERQAIADIGRF 683

  Fly   699 RPDRECDKD-SNPSCLRHRGAIHCVVSG-----TPVAQGAE-------------QQCCYDRYGFL 744
            .|...|.:. .:.:|....|:.:|.:|.     |....|.:             |.||||..|.|
 Worm   684 MPHPRCSQAFRDITCTTSIGSRNCYMSSQNVMTTYAGDGRQYNENLARFPTHYGQVCCYDDQGHL 748

  Fly   745 MLT-------------YDQMWGSRPRRVHNLGKMPWNEASKVPSLSMWFHDMRPFYSCCYWQEEQ 796
            |.|             |:..:   |.|.:..|..|:....:||.||.:.:|..|::.||.:.:.:
 Worm   749 MQTSYQPVIKVTPEVPYNPGF---PMRAYEFGTAPYMGQYEVPGLSAFHNDYMPYFLCCKFADFR 810

  Fly   797 AVGCETYRFERRPSQDCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLGEF--VLARSVDESNKFE 859
               |:.: :.||||..|..||.|....|.|...|.|.|...:.||..|.:  :.......:.:.:
 Worm   811 ---CQMF-YWRRPSSGCQEYQPPAYGEVMGAGTFNTIDNDKFIFNEPGVYNGLYIPHTLSTPEVK 871

  Fly   860 VQGRFEQLP---------VNYYGE------VKATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLD 909
            ||.|.|:.|         ..|..:      ..||.:|.|.:....|..:.|..|....|:|||..
 Worm   872 VQIRMERYPNRRVDFSLLGRYMAQQDLVQPTNATVVTGVVLEATGTDRVHVVARKDTRRFRYRTS 936

  Fly   910 VLADGRRVYFDRESLKFQHFDGVTVYTPTYLLNQSQV-VVQFDAGIGV--------------EVV 959
            ::......|||  :::.|.|.||.:|.......|.:: ||..:|.||:              |..
 Worm   937 IIVGNILRYFD--TMRIQRFKGVMIYVNNVERGQPEIYVVLEEAQIGIRVRESYAIDIDRLSEYQ 999

  Fly   960 ENEGYMTGRVFLPWKF-------------------INKTAGLFGNWSFNKLDDFMLPNGQVAQLN 1005
            |:.|.:...|.:|.::                   :.:.:|:|..:.......::      ..|.
 Worm  1000 ESMGILNIAVSVPPQYGVRPDGDKTREQEIRQRYNLPRVSGVFRPFPDQSSGSYL------NTLT 1058

  Fly  1006 LNDLRS------------------------IH---TNFGI---KWMLTDR----------EVPGV 1030
            |||:.|                        |:   .|:|:   ....|.|          |....
 Worm  1059 LNDVNSETYRQQIINMYRVQGSGEPGSDQNINNQGNNYGMPTENMFTTSRDEDKKFEVFPEAQMK 1123

  Fly  1031 GAALFKR---------EFGRMSGYYANATFQ--------PNYVLDPADF----------LPANRS 1068
            ...:||.         .|..|:|...|...|        .|..:.|...          .|.|.|
 Worm  1124 SGPIFKTSPKYETGAYRFYPMTGQVLNQRLQTCRDMQQNTNINMQPLQSQLTGEYGQTQCPDNPS 1188

  Fly  1069 YDLERAEELCGECMQCQYDYAMTLNRDLAHFTKNYYDTIVNMQAENAVRVVSCGV--LQTPRFGR 1131
            ..::.    ||:.:.|.|||.....:.|....||.::|..:.:.:.:.:..||||  ::.|.:..
 Worm  1189 SIIQD----CGDSVPCLYDYYNFNAKLLGLNVKNEWNTFTSDRFDASRQYNSCGVINIEYPEYLM 1249

  Fly  1132 K---LSFDFMPGAKVSFECNEGFILIGDQRRECLSNGL------------------WNIPEYGYT 1175
            |   :|..::.|....|||.:...:.|....:|   |:                  ||..|..:.
 Worm  1250 KTSSMSSAYLQGDVARFECFQSHWIYGVHEYKC---GIVVDRNQRNIIDPRDYRFEWNKGEQPWC 1311

  Fly  1176 ECLREVYYTRRVAFIAIGIIFLVICPLMLCIVCGVYRYRQKQLKEDPQWQMPMLPRSRASSARNL 1240
            ....:..:...:|.|. ||..:::..:::.:.|.:.:.::|               ..|:..|
 Worm  1312 RSREKQNFLTWLAIIG-GIFGVLVFVILIFLCCWIVKQKKK---------------GEAAERR-- 1358

  Fly  1241 RTLNYDDDSDTDASTLKKSRSYDKVYRTNEPLPGKPQIDFPAKKWDLDE-NDEDVTSSEGEKPKQ 1304
               .||..|.:..:..:..:.|.  ...:|||        ..|::|.|. .|:|......|:...
 Worm  1359 ---GYDMASRSSMTGSRGGKKYP--IHESEPL--------NEKRFDADTYRDDDFYPPAREEQYA 1410

  Fly  1305 LGRRSLH 1311
            .....||
 Worm  1411 ARNEDLH 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	47/208 (23%)
		TIG	446..511	CDD:460355	15/74 (20%)
		AMOP	660..803	CDD:461048	46/177 (26%)
		VWD	811..999	CDD:214566	50/238 (21%)
		CCP	1121..1171	CDD:214478	15/72 (21%)
F54D1.6	NP_502119.2	NIDO	185..349	CDD:470642	44/173 (25%)
		AMOP	638..818	CDD:128962	47/186 (25%)