Protein Alignment mesh and B0393.5

DIOPT Version :10

• Sequence 1: NP_001163782.1
• Gene: mesh / 43688
• FlyBaseID: FBgn0051004
• Length: 1454
• Species: Drosophila melanogaster
• Sequence 2: NP_497982.2
• Gene: B0393.5 / 175632
• WormBaseID: WBGene00007170
• Length: 1183
• Species: Caenorhabditis elegans
• Alignment Length: 1405
• Identity: 253/1405 - (18%)
• Similarity: 437/1405 - (31%)
• Gaps: 508/1405 - (36%)

  Fly    93 GTDDILTVAGLKPEKMFGALIMP----NDYLGELYDVDNSGYNWDPNN----NVAPPTTYSTAAG 149
            |.|::|.|..:....:|.  :.|    ..|..::.|        :||.    |:..|..:|
 Worm     3 GGDEVLVVLLIHLSLVFS--LHPFSGHQRYRRQILD--------EPNQQIDLNITVPYIFS---- 53

  Fly   150 GYTITAARLAELRSNFMYWYFDKDMYGGRGDYQFDIHASMTQLHKNLNFQLPFYGFRFNYTRLSL 214
                  |||....:|             |||  ..||... :::| |...:.|.|..:....:|.
 Worm    54 ------ARLYTYGAN-------------RGD--ISIHGRQ-EIYK-LENPIHFMGNVYESVYISR 95

  Fly   215 NGYLEFSDPPEYLTYPLVFPIKDWPAKRDPSFMGIFFSKCRVGRIY---PSDIDQRTPGVYFRVE 276
            :|.:.|::..:   .|...|::      :|: :.:|:....:|.::   .|||:      ...:.
 Worm    96 DGSVGFTEKRQ---KPSALPVE------EPT-IAVFWQPATLGNVWYRETSDIN------IMNLA 144

  Fly   277 RDLMGRTDRFGVEVRERTMWDIRQGVVGADTFIPKHVVIATWKNVSFAGGIDNSLYTT---NTFQ 338
            .:.:....|:|.:.|.|:                  ||:.||:      |:.:.|...   ||||
 Worm   145 HNEVNIQYRYGAQFRVRS------------------VVLITWE------GVKDPLVPESEGNTFQ 185

  Fly   339 MVLATDEVYTYIIFNYAVLNWLSHTEAGGDTTKGEGGVPAYVGFNAGNGTQAYEYNPYSQNMVIR 403
            :.|...:..|:..|.|:.||:.::..||..|......:|.    :|.|..           :::.
 Worm   186 LALIIGDSMTFAHFIYSKLNFNTNAIAGFSTRDSSYSLPD----SATNDA-----------ILLS 235

  Fly   404 DLANRGWANGFPGRHIFRVD-EQI-LIGSCNKDIDAALLPLTFAP----------------ESGN 450
            :.::    .|.||..:|||| ::| |.|:..|.::..   .:.||                :|.:
 Worm   236 EKSD----IGIPGEWLFRVDGDRIYLCGAGFKGLECI---ESCAPSQWFNDCSKSCHCDGGDSCD 293

  Fly   451 MLGGQVVNITGPCFDPAI-RVTCHFD-TESVLGTYVDRNRVIC--VQP-YLKAEG---YIRFQIS 507
            ...|:..|  |.|....| ...|..| .|..:|  :|.    |  .|| .|...|   .:.|:..
 Worm   294 QENGRCPN--GKCSPGWIGEPICDEDMDECEMG--IDN----CPNEQPDCLNTPGSFLCLCFEYD 350

  Fly   508 VGTQRFKWRGKYFVETPAAATEKIFFTTDDVHKKNPAEIRIT---WNQYNLTSNANANVMISLWG 569
            ...|:.| ..|  ...|:|..............:.|...::|   .|::..|:.|.:...|:...
 Worm   351 EAQQKCK-NSK--AAPPSAPIPVDVIPMHPTFTRKPTPPKVTAPPRNRFKSTTAATSPTFITETT 412

  Fly   570 YRET------KIEPQLEYIDVIEASYSNSGSYVITPSNYINRNNINRDMQFGFLQINLTQPDQYS 628
            .|:|      .|...|...:|:  :..:..:.|:|......|.:.|.....|.    .|..:.::
 Worm   413 TRQTTTTREKSISTPLLTTEVV--TRPSPTTTVVTAPAACARCDQNAKCSNGV----CTCSEGFT 471

  Fly   629 GLAISPVLWSRPIPLAWYMAPQWE------RQHGKRWARALCDNWIRA--------DRFLRNFAA 679
            |..           ...|...:.|      |.|      ::|.|.|.:        .||......
 Worm   472 GDG-----------FRCYDVDECEIPGAVCRDH------SICSNTIGSFECTCHGGYRFEDGKCE 519

  Fly   680 DLPLC---------PCTLDQAVLDKGRFR----------PDREC-------DKDS---NPSCLRH 715
            |:..|         |....:.:...|.|.          |..||       :.|:   |..|...
 Worm   520 DVDECRELPKICGDPNKGTKCINKDGTFECLCKDGYEGDPSSECRDVNECKNPDACGPNSQCTNT 584

  Fly   716 RGA--IHCVVSGTPVAQGA----EQQC-------------------CYDRYGFLMLTYDQMWGSR 755
            :|.  ..|:.....:|:||    ..:|                   |..|.||:         ..
 Worm   585 QGGYECECLAGFERIAEGAHCTDRDECAVEPCHPAAICSNTRGSYKCECRDGFV---------GD 640

  Fly   756 PRRVHNLGKMP-----------WNEASKVPSLSMWFHDMRPFYSCCYWQEEQAVGCETYRFERRP 809
            .:..|.....|           |:.::.||.||                       |...|.::.
 Worm   641 GKTCHETILYPISNDSTVIPRSWDSSTAVPILS-----------------------EITIFGKKY 682

  Fly   810 SQDCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLGEFVLARSVDESNKFEVQGRFEQL-----PV 869
            |:  :.....||         ::|||   ...||.:.  |.::.:...|.:..:|:.:     ..
 Worm   683 SK--IYLSTNGI---------ISFDG---PLQGLIDH--AETLKKPAIFALHAQFDYIREGLVAY 731

  Fly   870 NYYGEVKATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLDVLADGRRVYFDR----ESLKFQHFD 930
            .:..:..|..| .:.||.:......:.:.....:   ||.:..      |||    .|..|..|.
 Worm   732 TFINDTDAVTL-PLLMRSSIGIQTAMGIENFQTK---RLHIFT------FDRVRQSGSENFNSFQ 786

  Fly   931 GV--------TVYTPTYLLNQSQVVVQFDAGIGVEVVENEGYMTGRVFLPWKFINKTAGLFGNWS 987
            .|        |:.:..|                 |.|:..|.||| :..|.:|:
 Worm   787 IVLAESDKDATILSLIY-----------------EKVQARGPMTG-ISTPSRFL----------- 822

  Fly   988 FNKLDDFMLPNGQVAQLNLNDLRSIHTNFGI--KWM----LTDREV--PG-VGAALFKREFGRMS 1043
                   ||||.::|.         .:|.|.  |||    :.|.:.  || :|..|..||..  :
 Worm   823 -------MLPNNRLAS---------GSNVGQPGKWMYRVDIADLQTCPPGRLGEPLCDRECA--A 869

  Fly  1044 GYYANATFQPNYVLDPADFLPANRSYDLERAEELCGECMQCQYDY-AMTLNRDLAHFTKNYYDTI 1107
            |:|.         ::.......:.|...:....:|...: |:..: ..:.::|:.....:.....
 Worm   870 GHYG---------INCESTCHCDGSVACDVITGMCPGAL-CRAGWEGSSCDQDIDECEMSLVTCA 924

  Fly  1108 VNMQAENAVRVVSCGVLQTPRFGRKLSFDFMPGAKVSFECNEGFILIGDQRR---ECLSNGLWNI 1169
            |..|..|......|                        :|..||..:|.:.:   .|||.  :::
 Worm   925 VGSQCVNTRGGYRC------------------------DCKGGFAPVGKECKPIDRCLSR--FSV 963

  Fly  1170 PEYGYTECLREVYYTRRVAFIAIGIIFLVICPLMLCIVCGVYRYRQKQLKEDPQWQMPMLPRSRA 1234
            |.....||:..:...                |..:|         :|....|   ......|...
 Worm   964 PCSRNAECVESIESN----------------PKCVC---------RKGYHGD---GFRCTTRDNI 1000

  Fly  1235 SSA----------RNLRTLNYDDDSDTDA--------STLKKSRSYDKVYRTNEPL--------- 1272
            .||          .:|..:..|..:.||.        ..:.|:...|::..|..|:
 Worm  1001 KSAGGNILISDLTHHLMEVASDGTNSTDLPGTGLSENPFVMKNWVSDRIGETTTPVSQRPKFVTV 1065

  Fly  1273 ----------PGKPQIDFPAKKWDLDENDEDVTSSEGEKP 1302
                      |.||:|           ||:|:..|:||||
 Worm  1066 QTPPLFYTAPPIKPKI-----------NDKDMDLSDGEKP 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	32/165 (19%)
		TIG	446..511	CDD:460355	18/88 (20%)
		AMOP	660..803	CDD:461048	34/215 (16%)
		VWD	811..999	CDD:214566	36/204 (18%)
		CCP	1121..1171	CDD:214478	8/52 (15%)
B0393.5	NP_497982.2	NIDO	120..255	CDD:214712	38/183 (21%)
		EGF_CA	317..346	CDD:429571	9/34 (26%)
		EGF_3	453..477	CDD:463759	4/38 (11%)
		EGF_CA	479..507	CDD:429571	6/33 (18%)
		EGF_CA	520..554	CDD:429571	5/33 (15%)
		EGF_CA	565..606	CDD:214542	8/40 (20%)
		EGF_3	611..644	CDD:463759	5/41 (12%)
		NIDO	714..850	CDD:214712	35/190 (18%)
		EGF_CA	912..952	CDD:214542	9/63 (14%)
		EGF_3	964..994	CDD:463759	7/57 (12%)