DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mesh and B0393.5

DIOPT Version :9

Sequence 1:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster
Sequence 2:	NP_497982.2	Gene:	B0393.5 / 175632	WormBaseID:	WBGene00007170	Length:	1183	Species:	Caenorhabditis elegans

Alignment Length:	1405	Identity:	253/1405 - (18%)
Similarity:	437/1405 - (31%)	Gaps:	508/1405 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 GTDDILTVAGLKPEKMFGALIMP----NDYLGELYDVDNSGYNWDPNN----NVAPPTTYSTAAG 149
            |.|::|.|..:....:|.  :.|    ..|..::.|        :||.    |:..|..:|
Worm     3 GGDEVLVVLLIHLSLVFS--LHPFSGHQRYRRQILD--------EPNQQIDLNITVPYIFS---- 53

  Fly   150 GYTITAARLAELRSNFMYWYFDKDMYGGRGDYQFDIHASMTQLHKNLNFQLPFYGFRFNYTRLSL 214
                  |||....:|             |||  ..||... :::| |...:.|.|..:....:|.
Worm    54 ------ARLYTYGAN-------------RGD--ISIHGRQ-EIYK-LENPIHFMGNVYESVYISR 95

  Fly   215 NGYLEFSDPPEYLTYPLVFPIKDWPAKRDPSFMGIFFSKCRVGRIY---PSDIDQRTPGVYFRVE 276
            :|.:.|::..:   .|...|::      :|: :.:|:....:|.::   .|||:      ...:.
Worm    96 DGSVGFTEKRQ---KPSALPVE------EPT-IAVFWQPATLGNVWYRETSDIN------IMNLA 144

  Fly   277 RDLMGRTDRFGVEVRERTMWDIRQGVVGADTFIPKHVVIATWKNVSFAGGIDNSLYTT---NTFQ 338
            .:.:....|:|.:.|.|:                  ||:.||:      |:.:.|...   ||||
Worm   145 HNEVNIQYRYGAQFRVRS------------------VVLITWE------GVKDPLVPESEGNTFQ 185

  Fly   339 MVLATDEVYTYIIFNYAVLNWLSHTEAGGDTTKGEGGVPAYVGFNAGNGTQAYEYNPYSQNMVIR 403
            :.|...:..|:..|.|:.||:.::..||..|......:|.    :|.|..           :::.
Worm   186 LALIIGDSMTFAHFIYSKLNFNTNAIAGFSTRDSSYSLPD----SATNDA-----------ILLS 235

  Fly   404 DLANRGWANGFPGRHIFRVD-EQI-LIGSCNKDIDAALLPLTFAP----------------ESGN 450
            :.::    .|.||..:|||| ::| |.|:..|.::..   .:.||                :|.:
Worm   236 EKSD----IGIPGEWLFRVDGDRIYLCGAGFKGLECI---ESCAPSQWFNDCSKSCHCDGGDSCD 293

  Fly   451 MLGGQVVNITGPCFDPAI-RVTCHFD-TESVLGTYVDRNRVIC--VQP-YLKAEG---YIRFQIS 507
            ...|:..|  |.|....| ...|..| .|..:|  :|.    |  .|| .|...|   .:.|:..
Worm   294 QENGRCPN--GKCSPGWIGEPICDEDMDECEMG--IDN----CPNEQPDCLNTPGSFLCLCFEYD 350

  Fly   508 VGTQRFKWRGKYFVETPAAATEKIFFTTDDVHKKNPAEIRIT---WNQYNLTSNANANVMISLWG 569
            ...|:.| ..|  ...|:|..............:.|...::|   .|::..|:.|.:...|:...
Worm   351 EAQQKCK-NSK--AAPPSAPIPVDVIPMHPTFTRKPTPPKVTAPPRNRFKSTTAATSPTFITETT 412

  Fly   570 YRET------KIEPQLEYIDVIEASYSNSGSYVITPSNYINRNNINRDMQFGFLQINLTQPDQYS 628
            .|:|      .|...|...:|:  :..:..:.|:|......|.:.|.....|.    .|..:.::
Worm   413 TRQTTTTREKSISTPLLTTEVV--TRPSPTTTVVTAPAACARCDQNAKCSNGV----CTCSEGFT 471

  Fly   629 GLAISPVLWSRPIPLAWYMAPQWE------RQHGKRWARALCDNWIRA--------DRFLRNFAA 679
            |..           ...|...:.|      |.|      ::|.|.|.:        .||......
Worm   472 GDG-----------FRCYDVDECEIPGAVCRDH------SICSNTIGSFECTCHGGYRFEDGKCE 519

  Fly   680 DLPLC---------PCTLDQAVLDKGRFR----------PDREC-------DKDS---NPSCLRH 715
            |:..|         |....:.:...|.|.          |..||       :.|:   |..|...
Worm   520 DVDECRELPKICGDPNKGTKCINKDGTFECLCKDGYEGDPSSECRDVNECKNPDACGPNSQCTNT 584

  Fly   716 RGA--IHCVVSGTPVAQGA----EQQC-------------------CYDRYGFLMLTYDQMWGSR 755
            :|.  ..|:.....:|:||    ..:|                   |..|.||:         ..
Worm   585 QGGYECECLAGFERIAEGAHCTDRDECAVEPCHPAAICSNTRGSYKCECRDGFV---------GD 640

  Fly   756 PRRVHNLGKMP-----------WNEASKVPSLSMWFHDMRPFYSCCYWQEEQAVGCETYRFERRP 809
            .:..|.....|           |:.::.||.||                       |...|.::.
Worm   641 GKTCHETILYPISNDSTVIPRSWDSSTAVPILS-----------------------EITIFGKKY 682

  Fly   810 SQDCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLGEFVLARSVDESNKFEVQGRFEQL-----PV 869
            |:  :.....||         ::|||   ...||.:.  |.::.:...|.:..:|:.:     ..
Worm   683 SK--IYLSTNGI---------ISFDG---PLQGLIDH--AETLKKPAIFALHAQFDYIREGLVAY 731

  Fly   870 NYYGEVKATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLDVLADGRRVYFDR----ESLKFQHFD 930
            .:..:..|..| .:.||.:......:.:.....:   ||.:..      |||    .|..|..|.
Worm   732 TFINDTDAVTL-PLLMRSSIGIQTAMGIENFQTK---RLHIFT------FDRVRQSGSENFNSFQ 786

  Fly   931 GV--------TVYTPTYLLNQSQVVVQFDAGIGVEVVENEGYMTGRVFLPWKFINKTAGLFGNWS 987
            .|        |:.:..|                 |.|:..|.||| :..|.:|:
Worm   787 IVLAESDKDATILSLIY-----------------EKVQARGPMTG-ISTPSRFL----------- 822

  Fly   988 FNKLDDFMLPNGQVAQLNLNDLRSIHTNFGI--KWM----LTDREV--PG-VGAALFKREFGRMS 1043
                   ||||.::|.         .:|.|.  |||    :.|.:.  || :|..|..||..  :
Worm   823 -------MLPNNRLAS---------GSNVGQPGKWMYRVDIADLQTCPPGRLGEPLCDRECA--A 869

  Fly  1044 GYYANATFQPNYVLDPADFLPANRSYDLERAEELCGECMQCQYDY-AMTLNRDLAHFTKNYYDTI 1107
            |:|.         ::.......:.|...:....:|...: |:..: ..:.::|:.....:.....
Worm   870 GHYG---------INCESTCHCDGSVACDVITGMCPGAL-CRAGWEGSSCDQDIDECEMSLVTCA 924

  Fly  1108 VNMQAENAVRVVSCGVLQTPRFGRKLSFDFMPGAKVSFECNEGFILIGDQRR---ECLSNGLWNI 1169
            |..|..|......|                        :|..||..:|.:.:   .|||.  :::
Worm   925 VGSQCVNTRGGYRC------------------------DCKGGFAPVGKECKPIDRCLSR--FSV 963

  Fly  1170 PEYGYTECLREVYYTRRVAFIAIGIIFLVICPLMLCIVCGVYRYRQKQLKEDPQWQMPMLPRSRA 1234
            |.....||:..:...                |..:|         :|....|   ......|...
Worm   964 PCSRNAECVESIESN----------------PKCVC---------RKGYHGD---GFRCTTRDNI 1000

  Fly  1235 SSA----------RNLRTLNYDDDSDTDA--------STLKKSRSYDKVYRTNEPL--------- 1272
            .||          .:|..:..|..:.||.        ..:.|:...|::..|..|:
Worm  1001 KSAGGNILISDLTHHLMEVASDGTNSTDLPGTGLSENPFVMKNWVSDRIGETTTPVSQRPKFVTV 1065

  Fly  1273 ----------PGKPQIDFPAKKWDLDENDEDVTSSEGEKP 1302
                      |.||:|           ||:|:..|:||||
Worm  1066 QTPPLFYTAPPIKPKI-----------NDKDMDLSDGEKP 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	32/165 (19%)
		AMOP	660..805	CDD:281737	34/217 (16%)
		VWD	811..999	CDD:214566	36/204 (18%)
		CCP	1121..1171	CDD:214478	8/52 (15%)
B0393.5	NP_497982.2	NIDO	120..255	CDD:214712	38/183 (21%)
		EGF_3	453..477	CDD:289699	4/38 (11%)
		EGF_CA	479..>512	CDD:284955	6/38 (16%)
		EGF_CA	520..563	CDD:284955	6/42 (14%)
		EGF_CA	565..606	CDD:214542	8/40 (20%)
		EGF_3	611..644	CDD:289699	5/41 (12%)
		NIDO	714..850	CDD:214712	35/190 (18%)
		EGF_CA	912..952	CDD:214542	9/63 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4291
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810