DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mesh and Adgrl4

DIOPT Version :9

Sequence 1:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster
Sequence 2:	NP_573485.2	Gene:	Adgrl4 / 170757	MGIID:	2655562	Length:	739	Species:	Mus musculus

Alignment Length:	199	Identity:	46/199 - (23%)
Similarity:	70/199 - (35%)	Gaps:	52/199 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ANENISTEEFEDQIINAVPEP--------------VKVTKPKAQAEFVEVPKATPAPKKAEADNP 71
            |:.|.:..||.:.|.|.|...              :.:||....||.|.:..|....|.::.|..
Mouse   234 AHFNSTLTEFGETINNFVERSTHKMWDQLPTNHRRLHLTKLMHTAELVTLQIAQNTQKNSQFDMN 298

  Fly    72 KTKPLALQ----KPTLIPVVH-----------VSSR-----GTDDILTVAGLKPEKMFGALIMPN 116
            .| .|||:    ..|.:...|           :|.|     ||...:.||.| ..|..|.|:..:
Mouse   299 ST-DLALKVFAFDSTHMKHAHPHMNVDGGYVKISPRRKAAHGTTGNVVVAFL-CYKSIGPLLSSS 361

  Fly   117 DYLGELYDVDNSGYNWDPNNNVA-----------PPTTYSTAAGGYTITAARLAEL-RSNFMYWY 169
            |..  |.|..|.  |.:....|.           |||.|......:|::..:|::. |:...:|.
Mouse   362 DNF--LLDTQND--NSEGKEKVISSVISASISSNPPTLYELEKITFTLSHVKLSDKHRTQCAFWN 422

  Fly   170 FDKD 173
            :..|
Mouse   423 YSVD 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712
		AMOP	660..805	CDD:281737
		VWD	811..999	CDD:214566
		CCP	1121..1171	CDD:214478
Adgrl4	NP_573485.2	EGF_CA	58..91	CDD:214542
		EGF_CA	108..141	CDD:214542
		GAIN	190..370	CDD:293098	34/139 (24%)
		GPS	417..461	CDD:280071	2/10 (20%)
		7tm_4	473..709	CDD:304433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4291
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900