DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mesh and Muc4

DIOPT Version :9

Sequence 1:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster
Sequence 2:	NP_536705.4	Gene:	Muc4 / 140474	MGIID:	2153525	Length:	3990	Species:	Mus musculus

Alignment Length:	860	Identity:	194/860 - (22%)
Similarity:	309/860 - (35%)	Gaps:	233/860 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 PKHVVIATWKNVSFAGGI----DNSLYTTNTFQMVLATDEVYTYIIFNYAVLNWLSHTEAGGDTT 370
            |...|..::.:||.:.|:    ||...|.     |.||....|                :...||
Mouse  2837 PGPTVTESFSHVSSSSGLTTKTDNDRNTA-----VSATSSTLT----------------SPSPTT 2880

  Fly   371 KGEGGVPAYVGFNAGNGTQAYEYNPY--SQNMVIRDLANR--------GWANGFPGRHIFRVDE- 424
            .....|| ........|...:.|...  .||:..|.:...        |:..|...|..|.|.:
Mouse  2881 ASRSTVP-LPSLLPDQGISLFPYGSEVGDQNLFARTVDFNSPIFKILIGFPLGSSLRDSFYVTDN 2944

  Fly   425 -QILIGSCNKDIDAALLPLTFAPESGNMLGGQVVNITGPCFDPAIRVTCHFDTESVLGT------ 482
             ||:....:.|:.:...|    |:.| ..|.:.|.:..|.:..|       |..|..|.
Mouse  2945 GQIIFPESDYDVFSYPNP----PQRG-FTGRERVAMVAPFWADA-------DFSSSRGAIFYQEY 2997

  Fly   483 ---YVDRNRVI-----CVQPYLKAEGYIRFQISVGTQRFKWRGKY-FVETPAAATEKIFFTTDDV 538
               |.:.:::|     .:..:..:.||          |.||..|. :|..||...::.|.|
Mouse  2998 VTFYNEHHQLIREVETLINDFTSSWGY----------RAKWTLKVTWVNVPAYTAQESFGT---- 3048

  Fly   539 HKKNPAEIRITWNQYNLTSNANANVMISLWGYRETKIE---PQLEYIDVIEASYSNSGSYVITPS 600
                        |.|....:.:.:...:|:.|:.:.:.   .|..|..|:....|..|.:..:|.
Mouse  3049 ------------NTYQAILSTDGSRSYALFLYQNSGMRWDVTQEPYNRVLMGFSSGDGYFENSPL 3101

  Fly   601 NYINRNNINRDMQFGFLQINLTQPDQY--SGLAISPVLWSRPIPLAWYMAPQWERQHGKRWARAL 663
            .:  |..:.:           .:||::  |.|.|.        .|..|...:.||.:    .|..
Mouse  3102 TF--RPAMEK-----------YRPDRFLNSKLGIR--------GLQVYRLHREERPN----YRLK 3141

  Fly   664 CDNWIRADRFLRNFAADLPLCPCTLDQAVLDKGRFRP------DRE-CDKDSNPSCLRHRGAIHC 721
            |..|:.:.....::......|||:..|...| .||||      ||: |...|.      ||.: |
Mouse  3142 CLQWLESQPQQPSWGWSSVSCPCSWQQGQRD-FRFRPINPGWWDRQLCSFSSG------RGGV-C 3198

  Fly   722 VVSGTPVAQGAEQQCCYDRYGFLMLTYDQMWGSRPRRVHNLGKMPWNEASKVPSLSMWFHDMRPF 786
                          |.|..:|    .:.:.|     |:|:    || :..:......|
Mouse  3199 --------------CSYGAWG----EFREGW-----RMHS----PW-QFDEEQEAQNW------- 3228

  Fly   787 YSCCYWQEEQAVGCETYRFERRPSQDCVAYQAPGIAGVFGDPHFVTFDGTAYTFNGLGEFVLARS 851
              ||.|.::.:. |..|:. |||...|..|:.|..|..|||||..|.|...:||||||:|:|.::
Mouse  3229 --CCQWNDKPSF-CVWYQL-RRPRVSCAGYRPPRPAWTFGDPHITTLDNANFTFNGLGDFLLVQA 3289

  Fly   852 VDESNKFEVQGRFEQLPVNYYGEVKATQLTAVAMRGNTTT-----TIEVRLRPLHARWRYRLDVL 911
            .|.::.|.::||..|.     |..|||...|.|.:.||::     |::..|.|
Mouse  3290 QDRNSSFLLEGRTAQT-----GTAKATNFIAFAAQYNTSSLKSPITVQWFLEP------------ 3337

  Fly   912 ADGRRVYFDRESLKFQHFDG--VTVYTPTYLL---NQSQVVVQFDAGIGVEVVENEGYMTGRVFL 971
            :|..||.::.:::.|...|.  :.::..|.:|   |.|||...||..:.:.|:.....:.....|
Mouse  3338 SDKIRVVYNNQTVAFNTRDTEVLPIFNTTGVLLTQNGSQVSANFDGTVTISVIARSNILHASSSL 3402

  Fly   972 PWKFINKTAGLFGNWSFNKLDDFMLPNGQVAQLNLNDLRSIHTNFGIKWMLTDREVPGVGAALFK 1036
            ..::.|.|.||.|.|:.|..|||.:|||.....|.::....:  :|:.|     .|.|.|
Mouse  3403 SEEYRNHTEGLLGVWNDNPEDDFRMPNGSTIPSNSSEETLFY--YGMTW-----HVNGTG----- 3455

  Fly  1037 REFGRMSGYYANATFQPNYVLDPADFLPANRSYDLERA---EELCGEC---MQCQYDYAMTLNRD 1095
                 :.|..|:..        |..|.|...|..|.::   |:|...|   .:|.:|...|.||.
Mouse  3456 -----LLGIRADPL--------PTKFTPIFLSQLLNQSASGEDLASGCKGDRKCMFDILATGNRT 3507

  Fly  1096 LAHFTKNYYDTIVNM 1110
            :...|.:..:...:|
Mouse  3508 IGQSTNSILNEFQHM 3522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	24/122 (20%)
		AMOP	660..805	CDD:281737	33/151 (22%)
		VWD	811..999	CDD:214566	61/197 (31%)
		CCP	1121..1171	CDD:214478
Muc4	NP_536705.4	COG3889	<355..434	CDD:226406
		PRK08581	527..>743	CDD:236304
		Herpes_BLLF1	<1299..1718	CDD:282904
		Herpes_BLLF1	<1574..1872	CDD:282904
		ser_rich_anae_1	<2486..>2776	CDD:411418
		NIDO	2978..3135	CDD:214712	36/210 (17%)
		AMOP	3134..3246	CDD:128962	35/162 (22%)
		VWD	3250..3430	CDD:214566	61/196 (31%)
		EGF_CA	3905..3941	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7663
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296951at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020