Protein Alignment mesh and si:dkey-32n7.7

DIOPT Version :10

• Sequence 1: NP_001163782.1
• Gene: mesh / 43688
• FlyBaseID: FBgn0051004
• Length: 1454
• Species: Drosophila melanogaster
• Sequence 2: XP_073774180.1
• Gene: si:dkey-32n7.7 / 108191692
• ZFINID: ZDB-GENE-121214-179
• Length: 1672
• Species: Danio rerio
• Alignment Length: 1487
• Identity: 297/1487 - (19%)
• Similarity: 472/1487 - (31%)
• Gaps: 550/1487 - (36%)

  Fly     6 FVVCALACGFMAFVLAN-ENISTEEFEDQIINAVPEPVKVTKPKAQAEFVEVPKATPAPKKAEAD 69
            |.|..::.|.::||:.| .|||:   .||...|....:.:|      .:..||..| |.|.:.:.
Zfish   436 FQVILVSGGSLSFVMINYGNISS---TDQWFQAGYGTMNLT------NYFSVPIPT-ANKLSNSS 490

  Fly    70 NPKTKPLALQKPTLIPVVHVSSR-----------------GTDDILTVAGLKPEKMFGA-----L 112
            |                |::|.|                 |.:||     ..|.:.||:     |
Zfish   491 N----------------VNLSGRWAFRVDGGPEEGLFYPHGDEDI-----KNPAEDFGSSPLIHL 534

  Fly   113 IMPNDYLGELYD---VDNSG--------YNWDPN---------NNVAPPTT-----------YST 146
            ..|.:|.|.:|:   |:|.|        |.:.||         :.:||..|           |..
Zfish   535 AQPFNYFGLIYNRLYVNNKGYLTFKEPFYQYYPNLFTAYYSTRDIIAPLWTDIDITRNGAISYRQ 599

  Fly   147 AAGGYTITAAR--LAELRSNFMY---WYF----DKDMYGGRGDYQFDIHASMTQL--HKNLNFQL 200
            ...|:.:..|.  :.:...|..:   |.|    ||..|.|   |:..:......|  .||::|.|
Zfish   600 VTDGHVLNRASRDVNQYFPNLNFSASWVFIATWDKVPYYG---YRRSVSTFQIVLVSGKNMSFIL 661

  Fly   201 PFYGFRFNYTRLSLNGYLEFSDPPEYLTYPLVFP-----------IKDWPAKRDPSFM--GIFFS 252
            ..||..........:|| :.:|..::...|:..|           :..|..:.|.:..  |:|
Zfish   662 MHYGSISQAPYQVQSGY-DTTDSTDFFLIPVSDPKLLPYTSNVNMLGRWAFRIDNTSANNGLF-- 723

  Fly   253 KC------RVGRIYPSDIDQRTPGVYFRVERDLM----GRTDRFGVEVRERT------------- 294
             |      :|...|...|...||..|:.:...|:    .....|..:..|.|
Zfish   724 -CPFRNGYKVNMYYGYWISLPTPFPYYGLRHRLVKIHKNGFFTFNFQQEESTQAIPAYGFTDTVA 787

  Fly   295 -MW-DIRQGVVGADTFIPKH-------------------------VVIATWKNVSFAGGIDNSLY 332
             :| :|.:    :|.:| ||                         |...||.||.|:   :.|:.
Zfish   788 PLWTEIDE----SDVYI-KHFTGDRILQLVTKNINQYFPAFTADVVYSCTWDNVRFS---NTSIS 844

  Fly   333 TTNTFQMVLATDEVYTYIIFNYAVLNWLSHTEAGGDTTKGEGGVPAYVGFNAGNGTQAYEYNPYS 397
            .::|||::|.|....::||||||.:..:.|.              |..||:..:....|:. |.|
Zfish   845 QSSTFQVLLITGSGLSFIIFNYANIPQIKHI--------------ALAGFDTADSIVYYKI-PVS 894

  Fly   398 QNMVIRDLANRGWANGFPGRHIFRVDEQILIGSCNKDIDAALLPLTFAPESGNMLGGQVVNITGP 462
            .   |.||::....| |.||..||||                   |...|.|
Zfish   895 N---ITDLSHSTNVN-FTGRWAFRVD-------------------TLTTEYG------------- 923

  Fly   463 CFDPA--IRVTCHFDTESVLGTYVDRNRVICVQPY----LKAEGYIRFQISVGTQRFKWRGKYFV 521
            .|.|.  .::.|..:.:|.| .|:....:...:.|    :...||:.|..|..    :...|.|
Zfish   924 LFYPTKDSKLYCQSNADSHL-QYLRSPFLYFKRKYYNISVNCNGYLTFNESFN----EGSPKAF- 982

  Fly   522 ETPAAATEKI---FFTTDDVHKKNPAEIRITWNQYNLTSNANA--------------NVMISLWG 569
              |..:|..|   .:|..|.........||. ||..:...|..              .|:|:.|.
Zfish   983 --PGNSTRDIIAPLWTEFDSSVDTSVSYRIV-NQGRILERATTEIKQYFPLFGFSVHTVLIATWN 1044

  Fly   570 ----YRETKIEPQLEYIDVIEASYSNSGSYVITPSNYINRNNINRDMQFGFLQINLTQPDQYSGL 630
                |..:..:...:.:.|:..::    |:||  .||.|.::..:..|.|:..||.|.
Zfish  1045 RVPYYNSSLSDSSFQVVLVMCRTF----SFVI--MNYGNISSTGQRFQAGYDTINSTN------- 1096

  Fly   631 AISPVLWSRPIPLAWYMAPQWERQHGKRWARALCDNWIRADRFLRNFAADLPLCPCTLDQAVLDK 695
                 .:|.|:|....::.........||.                |..|
Zfish  1097 -----YFSIPLPDQNKLSKSSNVNVPGRWV----------------FRVD--------------- 1125

  Fly   696 GR-----FRPDRECDKDSNPSCLRHRGAIHCVVSGTPVAQGAEQQCCYDRYGFLMLTYDQMWGSR 755
            ||     |.|..:.:.:.||.  ...|      |..|:.       ....:.:...|||.::
Zfish  1126 GRSNEEIFYPYGDAEDEINPQ--SDDG------SSPPIP-------LLQSFVYFGNTYDTIF--- 1172

  Fly   756 PRRVHNLGKMPWNEASKVPSLSMWFHDMRPFYS-----CCYWQE--EQAVGCETYR------FER 807
               |:|.|.:.:::     .|..:..|..|.||     ...|.:  ....|..:||      ...
Zfish  1173 ---VNNNGDLTFDK-----PLHQYNPDNFPAYSTRDIIAPLWTDINNGMEGTISYRQVTNGDILN 1229

  Fly   808 RPSQDCVAYQAPGI----AGVFGDPHFVTFDGTAY--------TFNGLGEFVLARSVDESNKFEV 860
            |.|:|...| .|.:    :.||    ..|:|...|        ||    :.||..  |:...|.:
Zfish  1230 RASKDINRY-FPNLNFSASWVF----IATWDKVPYYGYRESESTF----QVVLVS--DKKRSFTL 1283

  Fly   861 QGRFEQLPVNYYGEVKATQL--TAVAMRGNT---------------TTTIEVRLRPLHARWRYRL 908
            .         :|..:..||.  :.....|:|               |:.:.|:     .||.:|:
Zfish  1284 M---------HYDYITYTQSAESGYDTNGSTVFYSIPVSDVTNLPYTSNVNVK-----GRWVFRV 1334

  Fly   909 DVLADGRRVYFDRESLKFQHFDGVTVYTPTYLLNQSQVVVQFDAGIGVEVVENEGYMTGR----V 969
            |..::.:               |..:.|.:..|:.....|   .|| :.|..:.|.:.|:    |
Zfish  1335 DNSSEVK---------------GSCINTNSQALDSPSAAV---CGI-IPVNSSNGTVGGQNSSAV 1380

  Fly   970 FLPWKFINKTAGLFGNWSFNKLDDFMLPNGQVAQLNLNDLRSIHTNFGIKWMLTDREVPGVGAAL 1034
            ..||:     |.|:  |.          :||....:|         ...:|:|:       .|..
Zfish  1381 HWPWQ-----ASLY--WY----------SGQTCGGSL---------INKEWVLS-------AAHC 1412

  Fly  1035 FKREFGRMSGYYANATFQPNYVLDPADFLPANRSYDLERAEELCGECMQCQYDYAMTLNRDLA-- 1097
            |.   |:.:|:|......|.          ....||..|........::..|....|.:.|:|
Zfish  1413 FN---GQRNGFYLTVILGPK----------TQNKYDPSRISRSVKAVIKHPYYNPNTNDNDIALV 1464

  Fly  1098 --HFTKNYYDTI--VNMQAENAV------------RVVSCGV-LQTPRFGRKLSFDFMPGAKVSF 1145
              .|...:.|:|  |.:.||.:|            |.:|.|| |.:|:..:::....:...
Zfish  1465 RLSFPITFTDSIRPVCLAAEGSVFNSDTESWITTWRNISDGVPLPSPKIFQEVEVPVIGNR---- 1525

  Fly  1146 ECN-------------------EGFILI-GDQRRECLSN--GLW---NIPEYG-----------Y 1174
            :||                   ||..|. ||.....:||  .:|   .|..:|           |
Zfish  1526 QCNCLYGVGSITDNMICAGLLKEGKDLCQGDSGGPMVSNQSSVWVQSGIVSFGSGCAQSEFPGVY 1590

  Fly  1175 TECLRE----VYYTRR-----VAFIAIGI--IFLVICP--LMLCIVCGVYRYRQKQL 1218
            |...|.    .|:|..     |.|.:.|.  .:...||  .:||....|.. :||||
Zfish  1591 TRVSRYQEWITYFTCSDPPGFVQFTSTGADPDYCYSCPGRPLLCNASAVVE-QQKQL 1646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	47/203 (23%)
		TIG	446..511	CDD:460355	13/70 (19%)
		AMOP	660..803	CDD:461048	24/154 (16%)
		VWD	811..999	CDD:214566	40/220 (18%)
		CCP	1121..1171	CDD:214478	15/75 (20%)
si:dkey-32n7.7	XP_073774180.1	None