DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mesh and tecta.1

DIOPT Version :9

Sequence 1:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster
Sequence 2:	XP_031762080.1	Gene:	tecta.1 / 100490936	XenbaseID:	XB-GENE-1011878	Length:	2144	Species:	Xenopus tropicalis

Alignment Length:	1256	Identity:	253/1256 - (20%)
Similarity:	413/1256 - (32%)	Gaps:	409/1256 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 LNFQLPFYGFRFNYTRLSL--NGYLEFSDPPEYLTYPLVFPIKDWPAKRDPSFMGIFFSKCRVGR 258
            :...:||..|...|..|.:  ||.:.|:......| |..||:.|..|     |:..|:
Frog    45 IKLSIPFIFFGVPYRTLYVNNNGVISFNVLLSQFT-PEAFPLSDGRA-----FIAPFW------- 96

  Fly   259 IYPSDIDQRTPG-VYFRVERDLMGRTDRFGVEVRERTMWDIRQGVVGADTFIPKHVVIATWKNVS 322
               :|:.....| :|::...|         ..:.::...:||:.......|....|...||..|:
Frog    97 ---ADVHNGIRGEIYYKETTD---------PAMLKKISKEIRKHFRNLPYFTATWVFSVTWDEVT 149

  Fly   323 FAGGIDNSLYTTNTFQMVLATDEVYTYIIFNYAVLNWLSHTEAGGDTTKGEGGVPAYVGFNAGNG 387
            |.||  :|....||||.:|.:|...::.:||||.:.|.:.|.:|||...|.|||.|..|||.|||
Frog   150 FYGG--SSTTPVNTFQALLISDGASSFSMFNYAEITWTTGTASGGDPLTGLGGVMAQAGFNGGNG 212

  Fly   388 TQAYEYNPYSQNMVIRDLANRGWANGFPGRHIFRVDEQILIGSCNKDIDAALLPLTFAPESGNML 452
            |..:.. |.|::..|.::......| .|||.::|:|        .|:||         |.:|..|
Frog   213 TNFFSV-PSSRSPEIVNIEETTNVN-VPGRWLYRID--------GKEID---------PANGCSL 258

  Fly   453 GGQVV------------NITGPCFDPAIRVTCHFDTESVLGTY--------------VDRNR-VI 490
            .|..:            ::...|.|....::|.   |||.|.|              |:.:. |:
Frog   259 KGNFLRQGESFWESANCSMRCRCLDINNEISCQ---ESVCGPYEVCEPKDKFFQCLPVESSTCVV 320

  Fly   491 CVQP-YLKAEGYI-RFQISVG--TQRFKWRGKYFVETPAAATEKIFFTTDDVHKKNPAEIRITW- 550
            ...| |...:|.: .||.|..  ..|..|.|.:..          ||:. :...:|.....::|
Frog   321 FGDPHYHTFDGLLFHFQGSCSYLLARHCWPGNHLP----------FFSV-EAKNENRGGSSVSWL 374

  Fly   551 -------NQYNLTSNANA-------NVMISLWGYRETKIEPQLEY--IDVIEASYSNS------- 592
                   ..||:....|:       |::.||        ...|||  |.:.::..|.:
Frog   375 KDISLEVYSYNIVIPKNSFGKVKVNNLIFSL--------PVNLEYGAIKIYQSGLSTAVETDFGL 431

  Fly   593 -----GSY---VITPSNYINR-----NNINRDMQFGFLQ---------INLTQ------PD---- 625
                 |.:   :..|..|||.     .|.|::.....|:         ::|.:      ||
Frog   432 LVMYDGQHYASISVPGTYINSTCGMCGNYNKNPTDDTLRSDGRPAVSVVDLGESWRVYHPDWRCS 496

  Fly   626 ---------------------QYSG---LAISPVLW---SRPIPLAWYMAPQWERQHGKRWARAL 663
                                 :|.|   :..|| ||   |...|.|:..:..::          |
Frog   497 PGCLDNCSSCDATTESLYFSSEYCGFINMTGSP-LWECGSVVDPTAFVHSCVYD----------L 550

  Fly   664 CDNWIRADRFLRNFAADLPLCPCTLDQAV-LDKGRFRPDRECDK--------------DSNP-SC 712
            |.:......|.::..|...:|     ||: :..|.:|....|..              .|.| :|
Frog   551 CGSGDNGTSFCQSIQAYALVC-----QALGIPVGDWRTQTSCASAVQCPEFSHYSVCTSSCPATC 610

  Fly   713 LRHRGAIHCVVSGTPVAQGAEQQCCYDRYGFLMLTYD----------QMWGSRPRRVHNLGKMPW 767
            ......::|   .:|..:|.|   |.:.|   :|:.|          :|.|    :.:.:|...|
Frog   611 ADIIAPLYC---NSPCTEGCE---CDEGY---VLSADACVPVSKCGCEMDG----KYYMVGDSFW 662

  Fly   768 NEASKVPSLSMWFH---DMRPFYSCCYWQEEQAV-----GCETYRFERRPSQDCVAYQAPGIAGV 824
            ..|.  .::..|..   |:..|.:.|...|..::     ||    :.||.|. |:..|...|
Frog   663 TSAD--CTVQCWCEDGGDVSCFNNTCRDGEICSIENGYQGC----YPRRESV-CLISQNQVI--- 717

  Fly   825 FGDPHFVTFDGTAYTFNGLGEFVLARSVDESNKF---EVQGRFEQLPVNYYGEVKATQLTAVAMR 886
                |  |||...:.|.....:.|.::..|..:|   ::..:......|:
Frog   718 ----H--TFDSVTFPFPLDYSYTLVKTCPEKAEFIEIDISKKKPDSSPNW--------------- 761

  Fly   887 GNTTTTIEVRLRPLHARWRYRLDVLADGRRVYFDRES-LKFQHFDGVTVYTPTYL--------LN 942
                      ||||      |:.|.....|:.....| :|...|:   |..|.||        .|
Frog   762 ----------LRPL------RIQVAKQDIRIGGGSNSEIKINGFE---VELPFYLPSGELEIYRN 807

  Fly   943 QSQVVVQFDAGIGVEVVENEGYMTGRVFLPWKFINKTAGLFGNWSFNKLDDFMLPNGQVAQLNLN 1007
            ::..|::.::.:.:: ..::|.:  .|.|...:.|.|.||.|.::.|..|:|..|||:...
Frog   808 RNGTVIESESYVKIQ-YSDQGLI--HVTLSTFYHNCTGGLCGYFNGNPDDEFCFPNGKCTD---- 865

  Fly  1008 DLRSIHTNFGI---KWMLTDREVPGVGAALFK--REFGRMSGYYANATFQPNYVLDP--ADFLPA 1065
                   |..|   .|...|....|....|.|  .....:..||.:.: :...:.||  :.||..
Frog   866 -------NVAIFLESWTTFDEICNGECGDLLKACNNDSELLKYYKSRS-KCGIINDPTNSSFLDC 922

  Fly  1066 NRSYDLE---------------RAEELCGECMQCQYDYAMTLNR---DLAHFTKNYYDTIVNMQA 1112
            :...::.               ...|||....:    |||....   |:..:....:..:|..:.
Frog   923 HAVVNVSAYYRTCLFRLCQSGGNQTELCDSVSR----YAMACQNAAVDVGQWRSKSFCPLVCPEN 983

  Fly  1113 ENAVRVVSC-GVLQTPRFGRKLSFDFMPGAKVSFECNEGFILIG--------------------- 1155
            .:....::| ....|...|...|.....|.    :|:|||.|.|
Frog   984 SHFDECITCTETCDTLASGPVCSDSCTEGC----QCDEGFALRGSYCVPKSECGCSYEGHQVSTN 1044

  Fly  1156 -------DQRRECLSNGLWNIPEYGYTECLREVY----------------------YTRRVAFIA 1191
                   |.:..|..||..|......|.|..:.|                      |...:.|..
Frog  1045 ATFWADLDCKSFCYCNGSDNSIYCESTPCKEDEYCMEDNGLYFCQPRTDASCIVSGYGHYLTFDG 1109

  Fly  1192 IGIIFLVICPLMLCIVCGVYR 1212
            :...|...|.|:||.....::
Frog  1110 LPFDFQSSCSLILCTTASNFK 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	49/160 (31%)
		AMOP	660..805	CDD:281737	33/178 (19%)
		VWD	811..999	CDD:214566	40/199 (20%)
		CCP	1121..1171	CDD:214478	16/78 (21%)
tecta.1	XP_031762080.1	NIDO	94..250	CDD:214712	53/186 (28%)
		VWC	260..305	CDD:327433	9/47 (19%)
		VWD	315..473	CDD:214566	33/176 (19%)
		C8	513..588	CDD:214843	18/90 (20%)
		TIL	593..646	CDD:410995	11/61 (18%)
		VWC	648..702	CDD:327433	12/63 (19%)
		VWD	707..861	CDD:214566	41/200 (21%)
		C8	902..977	CDD:214843	12/79 (15%)
		TIL	980..1032	CDD:410995	11/55 (20%)
		VWD	1086..1253	CDD:214566	7/45 (16%)
		C8	1293..1364	CDD:214843
		TIL	1368..1421	CDD:410995
		VWC	1423..1476	CDD:327433
		VWD	1483..1635	CDD:395046
		C8	1681..1748	CDD:214843
		ZP	1796..2050	CDD:214579
		FXa_inhibition	2080..2112	CDD:405372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9145
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000