DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mesh and muc4

DIOPT Version :9

Sequence 1:NP_001163782.1 Gene:mesh / 43688 FlyBaseID:FBgn0051004 Length:1454 Species:Drosophila melanogaster
Sequence 2:XP_031757776.1 Gene:muc4 / 100485162 XenbaseID:XB-GENE-852599 Length:5393 Species:Xenopus tropicalis


Alignment Length:1031 Identity:196/1031 - (19%)
Similarity:302/1031 - (29%) Gaps:433/1031 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 TTYSTAAGGYTITAARLAELRSNFMYWYFDKDMYGGRGDYQFDIHASMTQLHKNLNFQLPFY--- 203
            ||.|||....|..|..|..         :.||    .||.:|        :.:.::|..|.:   
 Frog  4163 TTISTANSSSTFPAVNLLS---------YGKD----AGDTEF--------VKRTVDFTSPLFQPQ 4206

  Fly   204 -GFRFN--------YT-------RLSLNGYLEFSDPPE---YLTYPLVFPIKDWPAKRDPSFMGI 249
             ||.|.        ||       ..|.|....:::||.   ...||:             :.:.:
 Frog  4207 LGFPFGNKLHTNIYYTDNGQIIFPASQNDIFSYTNPPVGGFTSNYPV-------------AMIAV 4258

  Fly   250 F-----FSKCRVGRIYPSDIDQRTPGV----YFRVERDLMGRTDRFGVEVRERTMWDIRQGVVGA 305
            |     ||| .||..|..:..:.:...    .|:|..|::.|.    |.......|         
 Frog  4259 FWDDADFSK-NVGTTYFQEYTKNSVSAASNSTFQVVEDMVRRY----VNASYTAQW--------- 4309

  Fly   306 DTFIPKHVVIATWKN------VSFAGGIDNSLYTTNTFQMVLATDEVYTYIIFNY--AVLNWLSH 362
                   ::..||:|      .:|:       ..|||:|.||.||...:|::..|  ..:||...
 Frog  4310 -------ILKITWENAPPYPAAAFS-------TQTNTYQAVLTTDGYISYVLMLYKDGAMNWNVS 4360

  Fly   363 TEAGGDTTKGEGGVPAYVGFNAGNGTQAYEYNPYSQNMVIRDLANRGWANGFPGRHIFRVDEQIL 427
            :....          ..:|:::|||..                                      
 Frog  4361 SRVAN----------VVMGYSSGNGDN-------------------------------------- 4377

  Fly   428 IGSCNKDIDAALLPLTFAPESGNMLGGQVVNITGPCFDPAIRVTCHFDTESVLGTYVDRNRVICV 492
                                                                             
 Frog  4378 ----------------------------------------------------------------- 4377

  Fly   493 QPYLKAEGYIRFQISVGTQRFKWRGKYFVETPAAATEKIFFTTDDVHKKNPAEIRITWNQYNLTS 557
                                                   |:..||:.|:.|:|.....|...|||
 Frog  4378 ---------------------------------------FYKNDDLMKRPPSERYRPCNYQGLTS 4403

  Fly   558 NANANVMISLWGYRETKIEPQLEYIDVIEASYSNSGSYVITPSNYINRNNINRDMQFGFLQINLT 622
               |||. .||.|                    |..|..::       ||               
 Frog  4404 ---ANVR-GLWIY--------------------NLNSQAVS-------NN--------------- 4422

  Fly   623 QPDQYSGLAISPVLWSRPIPLAWYMAPQWERQHGKRWARALCDNWIRADRFLRNFAADLPLCPCT 687
                                                  |..|..||.:......:.:.|..|||.
 Frog  4423 --------------------------------------RMTCMTWINSQPAPSTWNSGLVSCPCL 4449

  Fly   688 LDQAVLDKGRFRPDRECDKDSNPSCLRHRGAIHCVVSGTPVAQGAEQQCCY-DRYGFLMLTYDQM 751
            ..|.:.| .|||..:....          |:|..:.:..|....|..:|.| ::..||....::.
 Frog  4450 YQQGISD-SRFRKTKAGTS----------GSITMLRNTMPSRLKAGVRCLYLNKKQFLEGFQERS 4503

  Fly   752 WGSRPRRVHNLGKMPWNEASKVPSLSMWFHDMRPFYSCCYWQEEQAVGCETYRFERRPSQDCVAY 816
            |.| |...|:|                   ::..:..||...::... |..| .::||..:|.:|
 Frog  4504 WTS-PSSQHDL-------------------ELTAYDVCCNKLDDPQF-CSLY-IQKRPEINCRSY 4546

  Fly   817 QAPGIAGVFGDPHFVTFDGTAYTFNGLGEFVLARSVDESNKFEVQGRFEQLPVNYYGEVKATQLT 881
            ::.......||||..|.||..||||||.:|:|..:........:|||.||.     |..:||...
 Frog  4547 RSLSSGSSVGDPHMSTLDGLTYTFNGLDDFILLNATASVTSVILQGRTEQT-----GTARATNFQ 4606

  Fly   882 AVAMRGNTTTTIEVRLRPLHARWRYRLDVLADGRRVYFDRESLKFQHFDGVTVY-----TPTYLL 941
            |.|:: .|:.|..|::     .|....:   |....|.:.:::.|.:.:.:...     ...:|.
 Frog  4607 AFALQ-YTSDTSSVKV-----EWYLGTN---DSITTYVNGQNVTFGYSEDMDTMINDSNPDVFLS 4662

  Fly   942 NQSQVVVQFDAGIGVEVVENEGYMTGRVFLPWKFINKTAGLFGNWSFNKLDDFMLPNGQVAQLNL 1006
            ..:.|.......|.|.|....|.:.....||.:|..:|.||.|.|..|..:||.:|||.....|.
 Frog  4663 MNTSVSATLGGSITVSVSAYYGILNAITNLPSEFFGQTRGLLGVWDSNMSNDFQMPNGTSISTNS 4727

  Fly  1007 NDLRSIHTNFGIKWMLTD----------REVPGVGAALFKREFGRMSGY-YANATFQPNYVLDPA 1060
            :| ..|: |:|:.|.:|:          |...|....||.:|....:|| ..:||.|.|      
 Frog  4728 SD-EDIY-NYGMLWKVTEGNLFTEPKTQRPNNGTFKPLFLKELKNSNGYGQLSATCQNN------ 4784

  Fly  1061 DFLPANRSYDLERAEELCGECMQCQYDYAMTLNRDLAHFTKNYYDTIVNMQAENAV 1116
                                 ::|.||..:|.|.|||..|:   ..:|..||..|:
 Frog  4785 ---------------------LECIYDALVTNNTDLALATR---QAVVEFQATKAI 4816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
meshNP_001163782.1 NIDO 259..419 CDD:214712 27/171 (16%)
AMOP 660..805 CDD:281737 30/145 (21%)
VWD 811..999 CDD:214566 52/192 (27%)
CCP 1121..1171 CDD:214478
muc4XP_031757776.1 Herpes_BLLF1 <53..520 CDD:282904
EGF_CA 555..586 CDD:214542
EGF_CA 598..631 CDD:238011
EGF_CA 634..668 CDD:238011
EGF_CA 671..707 CDD:238011
EGF_CA 710..745 CDD:238011
EGF_CA 748..782 CDD:238011
EGF_3 789..824 CDD:403986
NIDO 907..1071 CDD:413419
VWD 1245..1407 CDD:413350
EGF_CA 1686..1727 CDD:214542
exchanger_TraA <1716..>2009 CDD:411343
EGF_CA 1771..1807 CDD:238011
EGF_CA 1808..1845 CDD:238011
EGF_3 1850..1885 CDD:403986
NIDO 4258..4412 CDD:413419 48/337 (14%)
AMOP 4421..4538 CDD:413460 32/202 (16%)
VWD 4556..4721 CDD:413350 51/178 (29%)
EGF_3 4984..5015 CDD:403986
EGF_CA 5017..5056 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D296951at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13802
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.110

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