DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mesh and si:ch73-181m17.1

DIOPT Version :9

Sequence 1:	NP_001163782.1	Gene:	mesh / 43688	FlyBaseID:	FBgn0051004	Length:	1454	Species:	Drosophila melanogaster
Sequence 2:	XP_009305151.1	Gene:	si:ch73-181m17.1 / 100330610	ZFINID:	ZDB-GENE-131122-49	Length:	2305	Species:	Danio rerio

Alignment Length:	1483	Identity:	270/1483 - (18%)
Similarity:	432/1483 - (29%)	Gaps:	543/1483 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 IPVVHVSSRG--TDDILTVAGLKPEKMFGALI-----------------------MPNDYLGELY 123
            :|...:.:.|  |.:.|::.|..|:...|.:|                       .|.||.  :|
Zfish   225 MPESCIGANGCNTQNSLSLNGPHPQIEDGVVIRELCGSVGFGCCAFRSTPIRVKACPGDYY--VY 287

  Fly   124 DVDN-----SGYNWDPNNNVAPPTTYSTAAGGYTITAARL------------AELRSNFMYWYFD 171
            ::.:     |||..|.:.....|||...|..|.:||....            ...||....|..|
Zfish   288 ELSDPSFPCSGYCIDVSTLSQLPTTSPAAITGSSITLINSDYDPCYNYNSLDNHWRSTHNNWLAD 352

  Fly   172 KDMYGGR-----GDYQFDIHASMTQLHKNLNFQLPFYGFRFNYTRLSLNGY--LEFSDPPEYLTY 229
            :..|...     |.|:..|:.|..::.:..            ::.:|..||  |...||     :
Zfish   353 EHAYDDSRVHWDGWYRLFINGSSAEIPERC------------FSHMSCGGYVSLWLGDP-----H 400

  Fly   230 PLVFPIKDWPAKRDPSFMGIFFSKCRVGRIYPSDIDQRTPGVYFRVERDLMGRTDRFGVEVRERT 294
            |   .::|....|  ...|..:.:|...|..|..: :..||.|:              |....|.
Zfish   401 P---QLEDGVVTR--KVYGSSYHQCNNYRSDPIQV-KACPGNYY--------------VYKLIRP 445

  Fly   295 MWDIRQGVVGADTFIP-------KHVVIATWKNVSFAGGIDNSLYTTNTFQMVLATDEVYTYIIF 352
            ...|...|..||...|       ..::...|:.:...|  .||.|..:...:|..:.....|:..
Zfish   446 KLTIPAPVYCADVRTPVSEPCTQYSILDDGWRGLQVLG--HNSPYNVHDDTLVEWSGWYRLYLNG 508

  Fly   353 NYAVLN-W-LSHTEAGGDTTKGEGGVPAYVGFNAGNGTQAY---EYNPYSQNMVIRDL--ANRGW 410
            ..|.|: | :|::|.||                   ||..|   .:......:|.||:  .:.||
Zfish   509 TSAQLSEWCVSYSECGG-------------------GTGLYLNASHPKLEDGVVTRDVLGMSSGW 554

  Fly   411 ANGFPGRHIFRVDEQILIGSCNKD--IDAALLPLTFAPE------SGNMLGGQVVNIT-GPCFDP 466
            :....|.:   ....|.:.:|..|  :...:.|.||.|.      :.|       ||: .||
Zfish   555 SFSQCGNY---RSNSIQVKACPGDYYVYELVKPSTFMPRPTYCTVAFN-------NISDDPC--- 606

  Fly   467 AIRVTCHFDTESVLGTYVDRNRVICVQPYLKAEGYIRFQISVGTQRFKWRGKYFVETPAAATEKI 531
                   ::.||     :||                           .||         |..|..
Zfish   607 -------YNYES-----LDR---------------------------PWR---------ATNESG 623

  Fly   532 FFTTDDVHKKNPAEIRITWN-QYNLTSN---------------ANANVMISLWG----------- 569
            ||..|..         .||| .|.|..|               .|....:||.|
Zfish   624 FFVCDGA---------FTWNGWYRLFCNGMNIRMPESCIGANGCNTQNSLSLNGPHPQIEDGVVI 679

  Fly   570 -------------YRETKIE----PQLEYI-DVIEASYSNSGSYVITPSNYINRNNINRDMQFGF 616
                         :|.|.|.    |...|: ::.:.|:..|| |.|             |:: ..
Zfish   680 RELCGSVGFGCCAFRSTPIRVKACPGDYYVYELSDPSFPCSG-YCI-------------DVR-TL 729

  Fly   617 LQINLTQPDQYSGLAISPV---------------LWSRPIPLAWYMAPQWERQHGKRWARALCDN 666
            .|:..|.|...:|.:|:.:               .| |.....|:     ..:|....:|...|.
Zfish   730 SQLPTTSPAAITGSSITLINADYDPCYNYNSLDNYW-RTTYNNWF-----ADEHAHDDSRVHWDG 788

  Fly   667 WIRADRFLRNFAADLP-------LC------------PCTLDQAVLDKGRFRPDRECDKDSNP-- 710
            |.|.  |:...:|::|       .|            |...|..|..|.......:|:..|:|
Zfish   789 WYRL--FINGSSAEIPEWCFTYMSCGGYVSLWLGDPHPQLEDGVVTRKVYGSIYNQCNYRSDPIQ 851

  Fly   711 --SC-------------LRHRGAIHCVVSGTPVAQGAEQQCCY-------------DRYGFLMLT 747
              :|             |.....::|.||    ...:....||             :.|...:..
Zfish   852 VKACPGNYYVYKLIRPKLTMPAPVYCAVS----FNTSNTDPCYNYTNLDEPWRASNNSYFGSVCD 912

  Fly   748 YDQMWGSRPRRVHNLGKMPWNEA--------SKVPSLSMWFHDMRP---------------FYSC 789
            |:.:|....|..:|...:...::        |..|   :|.:...|               :..|
Zfish   913 YNVVWNGWYRLFYNAQSVQMPDSCVSNGMCGSNQP---LWLNGSHPSLEDGVVTRQVCSPTWTDC 974

  Fly   790 CYWQEE--QAVGC--ETYRFERRPSQDCVAY--QAPGIAGVFGDPHFVTFDGTAYTFNGLGEFVL 848
            |.:...  |...|  ..|.:.......|.:|  :...|:.:......||.        ...|..:
Zfish   975 CGYTSHPIQVKACPGNYYVYHLTKPTFCSSYCAEVTEISNILASTTAVTI--------STQESPI 1031

  Fly   849 ARSVDESNKFEVQGRFEQLPVNYYGEVKATQLTAVAMRGNTTTTIEVRLRPLHARWR--YRLDVL 911
            |.|  |::.|:....:..|. ||:..|..||.:::..             .:...|.  |||
Zfish  1032 ATS--EADPFDPCYNYTVLD-NYWRSVNNTQFSSIRC-------------DMSVNWNGWYRL--- 1077

  Fly   912 ADGRRVYFDRESLKFQHFDGVTVYTPTYLLNQSQVVVQFDAGIGVEVVENEGYMTGRVFLPWKFI 976
                            :..|.:...|...:|:..........:..|....|..:.
Zfish  1078 ----------------YISGQSAQMPDTCVNELSCSTHAPLWLNGEHPHVEDGVV---------- 1116

  Fly   977 NKTAGLFGNWSFNKLDDFMLPNGQVAQLNLNDLRSIHTNFGIKWMLTDREVPGVGAALFKREFGR 1041
              |..:.|:|:                   ||....|:|     .:..:..||
Zfish  1117 --TRSICGHWN-------------------NDCCYFHSN-----PIQVKACPG------------ 1143

  Fly  1042 MSGYYANATFQPNYVLDPADFLPANRSYDLERAEELCGECMQCQYDYAMTLN--RDLAHFTKNYY 1104
              .||......|::...         :|..|........|    :.|::...  |||.....|||
Zfish  1144 --SYYVYEFVSPSFCFG---------TYCAEVTTSSSDPC----FGYSVIDENWRDLRQDYYNYY 1193

  Fly  1105 ------DTIVN--------MQAENAVRVVSCGVLQTPRFGRKLSFDFMPGAKVSFECNEGFILIG 1155
                  ||:|:        :..:||.....| |.|: ..|..::. |:.|:....|  :|.:
Zfish  1194 SFYGHDDTLVDWKGWYRLYLNGKNAQLSEWC-VTQS-GCGGDIAL-FLNGSHPRLE--DGVV--- 1250

  Fly  1156 DQRRECLSNGLWNIPEYGYTECLREVYYTRRVAFIAIGIIFLVICPLMLCIVCGVYRYRQKQLKE 1220
              .||.|  |.|:...:.:...    :||               ....|...||.|:....|:|.
Zfish  1251 --TREVL--GTWSSSSWVWWWW----WYT---------------WSFDLSKQCGYYKSSSIQVKA 1292

  Fly  1221 DP-QWQMPMLPRSRASSARNLR-TLNYDDDSDTDASTLKKSRSYDKVYR-TNEPLPGKPQIDFPA 1282
            .| .:.:..|.|..||..|... |:.:|..::......:   |.|:.:| |||.........|..
Zfish  1293 CPGDYYVYELVRPNASMIRPAYCTVAFDSINNDPCYNYE---SLDRPWRATNESGFSVSDEFFSW 1354

  Fly  1283 KKW-DLDENDEDVTSSEGEKPKQLGRRSLHSASGTELDQHGSPVDGDHPDEDD 1334
            ..| .|..|..::..||    ..:||...::.||..|       .|.||..||
Zfish  1355 NGWYRLFYNGMNIQMSE----SCIGRYVCNAFSGLSL-------KGPHPQIDD 1396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mesh	NP_001163782.1	NIDO	259..419	CDD:214712	34/173 (20%)
		AMOP	660..805	CDD:281737	36/220 (16%)
		VWD	811..999	CDD:214566	28/191 (15%)
		CCP	1121..1171	CDD:214478	13/49 (27%)
si:ch73-181m17.1	XP_009305151.1	NIDO	1825..1960	CDD:295411
		ZP	2015..2264	CDD:214579
		Zona_pellucida	2144..2262	CDD:278526
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4291
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810