DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and Phlpp1

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_598582.3	Gene:	Phlpp1 / 98432	MGIID:	2138327	Length:	1687	Species:	Mus musculus

Alignment Length:	504	Identity:	107/504 - (21%)
Similarity:	172/504 - (34%)	Gaps:	149/504 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 VDAKKDEVPDDMEFLCEAPLISPAT-------FCKVF--------PFHLMFDRQMKIV----QAG 353
            |.:.||.|...|..|   |||....       .|..|        .:::.||...:.:    |..
Mouse   527 VSSVKDSVSGKMHVL---PLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVS 588

  Fly   354 KAVSRVIPRVAEENCSLIEVVEAIRPHLQLN--FENILSHINT----IYVLQTRQGAMSSRHEQR 412
            |..|:.|..|....|||        .||..|  :...|:|:|.    :....|...|......||
Mouse   589 KVASQRISSVDLSCCSL--------EHLPANLFYSQDLTHLNLKQNFLRQTPTLPAARGLGELQR 645

  Fly   413 FLRLK-------------GQMMYIPETDRILFQC-----YPS----VMNLDDLTKKGLYISDVPL 455
            |.:||             ..:..||....:...|     .|:    :.||......|.::..:|.
Mouse   646 FTKLKSLNLSNNHLGAFPSAVCSIPTLAELNVSCNALREVPAAVGDMQNLQTFLLDGNFLQSLPA 710

  Fly   456 H-DAARDLVLLSEKFEAEYKLTKNLEMLT--DKL-----------QQTFRDLESEKQKTDRLLYS 506
            . ::...|..|...|.....:.:.||.||  |||           .|..|.:...|....||  :
Mouse   711 ELESMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAGNCVETLRLQALRRMPHIKHVDLRL--N 773

  Fly   507 VLPKSVANELRHQRPVPP------KRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKM------ 559
            :|.|.:|:|:...:.|..      |..|...::|:.|...  :|..|       ::|.:
Mouse   774 ILRKLMADEVDFVQHVTQLDLRDNKLGDLDAMIFNNIEVL--HCERN-------QLVTLNVCGYF 829

  Fly   560 LNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAK---CMARVALDMMDMAKNVK 621
            |..||    |.::....|:||.|    ..|::...:..:|.:...   |.:| .|:::|:..| :
Mouse   830 LKALY----ASSNELAQLDVYPV----PNYLSYMDVSRNCLESVPEWVCESR-KLEVLDIGHN-Q 884

  Fly   622 MGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGV-------------PGRIN 673
            :...|.::.......:::.|  .||:.|         |..|.|.|.|             |..:.
Mouse   885 ICELPARLFCNSSLRKLLAG--HNRLAR---------LPERLERTSVEVLDVQHNQITELPPNLL 938

  Fly   674 VSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSIL 722
            :..::.|.|..:.|:     ||...|..            |:..|||||
Mouse   939 MKADSLRFLNASANK-----LETLPPAT------------LSEETSSIL 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	54/250 (22%)
		CYCc	496..688	CDD:214485	43/219 (20%)
		Guanylate_cyc	522..714	CDD:278633	40/219 (18%)
Phlpp1	NP_598582.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..406
		PH_PHLPP-like	491..587	CDD:270131	13/62 (21%)
		PH	511..592	CDD:278594	15/67 (22%)
		LRR_RI	581..885	CDD:238064	71/332 (21%)
		LRR_8	594..659	CDD:290566	18/72 (25%)
		LRR 1	594..615		8/28 (29%)
		leucine-rich repeat	597..617	CDD:275380	7/27 (26%)
		LRR 2	617..638		4/20 (20%)
		leucine-rich repeat	618..648	CDD:275380	8/29 (28%)
		LRR_8	647..726	CDD:290566	12/78 (15%)
		LRR 3	648..669		2/20 (10%)
		LRR 4	671..692		2/20 (10%)
		leucine-rich repeat	672..694	CDD:275380	2/21 (10%)
		LRR 5	694..715		4/20 (20%)
		leucine-rich repeat	695..717	CDD:275380	3/21 (14%)
		LRR 6	717..739		5/21 (24%)
		leucine-rich repeat	718..740	CDD:275380	6/21 (29%)
		LRR 7	740..760		4/19 (21%)
		leucine-rich repeat	741..764	CDD:275380	5/22 (23%)
		LRR 8	764..785		7/22 (32%)
		LRR_RI	768..1030	CDD:238064	52/252 (21%)
		leucine-rich repeat	768..788	CDD:275380	6/21 (29%)
		LRR 9	788..809		4/20 (20%)
		leucine-rich repeat	789..809	CDD:275380	4/19 (21%)
		leucine-rich repeat	810..851	CDD:275380	12/57 (21%)
		LRR 10	829..850		8/28 (29%)
		LRR 11	851..872		3/20 (15%)
		leucine-rich repeat	852..874	CDD:275380	3/22 (14%)
		LRR 12	874..895		4/21 (19%)
		leucine-rich repeat	875..897	CDD:275380	4/22 (18%)
		LRR_8	896..954	CDD:290566	13/73 (18%)
		LRR 13	897..918		7/31 (23%)
		leucine-rich repeat	898..919	CDD:275380	7/31 (23%)
		LRR 14	919..940		2/20 (10%)
		leucine-rich repeat	920..943	CDD:275380	2/22 (9%)
		LRR 15	943..964		7/37 (19%)
		leucine-rich repeat	944..967	CDD:275380	7/39 (18%)
		LRR 16	969..989		2/2 (100%)
		LRR_8	970..1028	CDD:290566	1/1 (100%)
		leucine-rich repeat	970..993	CDD:275380	1/1 (100%)
		LRR 17	993..1014
		leucine-rich repeat	994..1017	CDD:275380
		LRR 18	1017..1038
		LRR 19	1040..1061
		LRR 20	1062..1083
		leucine-rich repeat	1063..1085	CDD:275380
		LRR 21	1085..1106
		PP2Cc	1124..1376	CDD:214625
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1414..1465
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1604..1687
		PDZ-binding	1685..1687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900